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Terms Of Use

CLOMIFENE CITRATE (CLOMIFENE)

Brand Name(s) : Clomid, Clomifene
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

CLOMIFENE CITRATE WARNINGS

Clomifene citrate should be used with caution in:

  • Women with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
  • Women with uterine fibroids
  • Women suffering from depression
  • Women with, or increased risk of, thrombophlebitis (inflammation of a vein)
  • Women with polycystic ovary syndrome (a condition with many small cysts on the ovaries)

It should not be used in:

  • Allergy to clomifene citrate, or any of the ingredients in the medicine
  • Children, adolescents and men, or women who have already gone through the menopause (post-menopausal)
  • Women with liver disease or history of liver problems
  • Women with uterine bleeding due to an unknown cause
  • Women with ovarian cysts, with the exception of polycystic ovary syndrome
  • Women with hormone-dependent tumours such as pituitary or ovarian tumours
  • Pregnant women
  • Women breastfeeding

Warnings with use of clomifene citrate:

  • There is an increased risk of multiple pregnancies (more than one child in a single pregnancy), ectopic pregnancies (where the baby grows outside of the womb) as well as an increased risk of ovarian cancer or ovarian cysts.

This medication should not be used for long-term use, as its safety has not be established.

Also see list of precautions and interactions

STORAGE

Do not store above 25°C.

CLOMIFENE CITRATE USES

What is it used for?

  • Clomifene citrate is used to treat female infertility.
  • It is an ovulation stimulant (makes the ovaries produce more eggs), and also has anti-oestrogen activity.
  • It is used to treat women with infertility, where it is due to failure of release of eggs from the ovary (ovulation). This type of infertility is known as anovulatory infertility. Clomifene citrate increases the chance of ovulation, therefore increasing the chance of conceiving (getting pregnant).
  • In general this drug is used to treat anovulatory infertility and increases the chance of getting pregnant.
  • Benefits of being on this drug may include a successful pregnancy.

Listed below are the typical uses of clomifene citrate.

  • Treatment of anovulatory infertility

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication exactly as your doctor has told you. This medication is taken in treatment cycles of 5 days.
  • This medication is not recommended during pregnancy so appropriate tests should be taken to determine whether you are pregnant or not.
  • If required, this medication can be given for up to 3 treatment cycles. It is important to follow instructions of use as advised by your doctor. Additional information can be found in the Patient Information Leaflet.
  • Take this medication by mouth usually once daily for 5 days in a given cycle, with or without food. The medication should be swallowed whole with a little water, and should not be crushed or chewed.
  • Use this medication for duration of prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Visual disturbances, such as blurred vision may occur while on this medication, especially in differing light conditions. The visual disturbances may gradually progress. If you are affected you should avoid driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • Unless you think you are pregnant, or are pregnant, always complete the full course as prescribed by your doctor.

CLOMIFENE CITRATE SIDE EFFECTS

  • Skin flushing
  • Nausea and vomiting
  • Breast discomfort
  • Headaches
  • Heavy or prolonged periods, or bleeding between periods
  • Dizziness
  • Lightheaded feeling/ vertigo
  • Tiredness
  • Depression
  • Sleeping difficulties
  • Rash or itching of the skin (urticaria)
  • Hair loss

If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms and stop taking clomifene citrate immediately:

  • Pain in the abdomen or pelvis, weight gain, discomfort (signs of ovarian enlargement, ovarian cysts or ovarian cancer)
  • Visual disturbances, such as blurring, spots or flashes before the eyes
  • Yellowing of eyes or skin (signs of liver problems)

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website

CLOMIFENE CITRATE PRECAUTIONS

Before taking clomifene citrate, tell your doctor or pharmacist if you are allergic to it; or to other ovulation stimulants; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Allergy to clomifene citrate, or any of its ingredients
  • Liver disease or history of liver problems
  • Uterine bleeding due to an unknown cause
  • Ovarian cysts, with the exception of polycystic ovary syndrome
  • Hormone-dependent tumours such as, pituitary or ovarian tumours

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
  • Uterine fibroids
  • Depression
  • Thrombophlebitis (inflammation of a vein), or at risk of developing it
  • Polycystic ovary syndrome (a condition with many small cysts on the ovaries)

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect clomifene citrate.

The elderly: clomifene citrate should not be used in the elderly, or any women who have gone through the menopause (post-menopausal).

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Clomifene citrate is not safe to take if you are pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether clomifene citrate passes into breast milk. The manufacturer therefore states that it should not be taken if you are breastfeeding. The medication may reduce breast milk.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

CLOMIFENE CITRATE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: None known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of: None known.

This information does not contain all possible interactions. Therefore, before using clomifene citrate, tell your doctor or pharmacist of all the products you use.

CLOMIFENE CITRATE OVERDOSE

An overdose of clomifene citrate may cause over-stimulation of the ovary. Symptoms of this may include pain in your pelvis, stomach or calf, swelling or feeling bloated, decrease in urine output, difficulties breathing or an increase in weight.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of clomifene citrate or intentional overdose is suspected, contact your local hospital, GP or if in England call 111 or NHS Direct. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, please inform your doctor. Skip the missed dose and resume your usual dosing schedule the following day. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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