Boots WebMD Partners in Health
Return To Boots

Medicines & treatments centre

Terms Of Use

CLOPIDOGREL (PLAVIX)

Brand Name(s) : Plavix, Grepid
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

CLOPIDOGREL WARNINGS

Clopidogrel should be used with caution in:

  • Any condition that puts you at risk of internal bleeding (such as a stomach ulcer)
  • Blood disorders which increase the risk of internal bleeding
  • Recent serious injury
  • Recent surgery (including dental)
  • Planned surgery (including dental) in the next seven days
  • Kidney or liver problems
  • Recent ischaemic stroke (blood clot in an artery of the brain)
  • Use of other drugs which increase the risk of bleeding

It should not be used in:

  • If you are allergic (hypersensitive) to clopidogrel or any other ingredient in the medicine
  • While on warfarin or other oral anticoagulant
  • If you have a medical condition that is currently causing bleeding such as a stomach ulcer;
  • Severe liver disease

Also see list of precautions and interactions

STORAGE

Store in the original package.

CLOPIDOGREL USES

What is it used for?

  • Clopidogrel is used to prevent blood clots forming in hardened arteries thereby reducing the risk of heart attacks and strokes .
  • It is an antiplatelet drug.
  • It is used to prevent blood clots forming. Platelets are cells in the blood that clump together to form blood clots. By preventing this clamping, antiplatelet medicines reduce the likelihood of blood clots forming (a process called thrombosis). This can in turn reduce the risk of severe event such as heart attacks, strokes or death.
  • In general this drug is used in patients who are at higher risk of heart attacks or strokes due to hardening of the arteries (atherosclerosis), if you have already had a heart attack or stroke or have peripheral artery disease (narrowing of the arteries in the arms or legs), or if you have experienced unstable angina ( a severe type of chest pain).
  • Benefits of being on this drug can include reducing the risk of heart attacks and strokes.

Listed below are the typical uses of clopidogrel.

  • Atherosclerosis (a condition of hardening of the arteries)
  • Recent heart attack or stroke
  • Peripheral artery disease
  • Unstable angina

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • With aspirin, for the prevention of thrombosis (blood clotting) after placement of an intracoronary stent

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally (by mouth) usually once daily, with or without food.

Use this medication regularly in order to get the most benefit from it.

Remember to use it at the same time each day - unless specifically told otherwise by your doctor.

Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Clopidogrel has no effect on driving or machinery operation. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

CLOPIDOGREL SIDE EFFECTS

If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Fever, signs of infection or extreme tiredness. These may be due to a decrease in some blood cells.
  • Signs of liver problems such as yellowing of the skin and/or the eyes (jaundice), whether or not associated with bleeding and/or confusion

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

CLOPIDOGREL PRECAUTIONS

Before taking clopidogrel, tell your doctor or pharmacist if you are allergic to it; or to other antiplatelets; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if: you are taking warfarin (another anticoagulant), you are allergic (hypersensitive) to clopidogrel or the other components of the tablets, you have a medical condition that is currently causing bleeding such as a stomach ulcer, severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any medical condition that puts you at risk of internal bleeding (such as a stomach ulcer), recent serious injury or surgery (including dental), planned surgery (including dental) in the next seven days, recent ischaemic stroke (blood clot in an artery of the brain)

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect clopidogrel.

The elderly: clopidogrel can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Clopidogrel is not recommended during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.
First trimester: avoid
Second trimester: avoid
Third trimester: avoid

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Clopidogrel is not safe to take if you are breastfeeding

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

CLOPIDOGREL INTERACTIONS

Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with clopidogrel:

  • Non-steroidal anti-inflammatory drugs used to treat painful or inflammatory conditions e.g. aspirin
  • Oral anticoagulants, used to reduce blood clotting
  • Heparin or any other injectable medicines used to reduce blood clots
  • Cimetidine, omeprazole, esomeprazole, used to treat upset stomach
  • Fluconazole, voriconazole, used to treat fungal infections
  • Ciprofloxacin, chloramphenicol used to treat bacterial infections
  • Fluoxetine, fluvoxamine, moclobemide used to treat depression
  • Carbamazepine or oxcarbazepine used to treat some forms of epilepsy

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.

CLOPIDOGREL OVERDOSE

If you take more Plavix than you should contact your doctor or the nearest emergency department because of the increased risk of bleeding.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of clopidogrel or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, but remember within 12 hours of your usual time, take your tablet straightaway and then take your next tablet at the usual time. If you forget for more than 12 hours, simply take the next single dose at the usual time. Do not double the dose to catch up.

Find a medication

Search by medication name for information on over-the-counter or prescription medications including side effects and interactions.
indicates detailed medicines information

Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

Search for a medicine or treatment

Search by medicine name or treatment for information including side effects and interactions.

Ex. Simvastatin, Ibuprofen, Amitriptyline Hydrochlorine

Popular slideshows & tools on BootsWebMD

woman_holding_head_in_pain
How to help headache pain
man in mirror
How smoking affects your looks & life
boost your metabolism
Foods to lower LDL (bad) cholesterol
period_questions_answered
Tips to support digestive health
woman looking at pregnancy test
Is your body ready for pregnancy?
woman holding mouth
Common mouth problems
couple makigh salad
Nutrition for over 50s
bucket with cleaning supplies in it
Cleaning and organising tips
adult man contemplating
When illness makes it hard to eat
Allergies
Allergy myths and facts
egg in cup
Surprising things that can harm your liver