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CO-BENELDOPA (MADOPAR)

Brand Name(s) : Madopar, Madopar CR
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

CO-BENELDOPA WARNINGS

Co-beneldopa should be used with caution in:

It should not be used in:

  • People with known hypersensitivity to levodopa or benserazide or any of the other ingredients in the medication
  • People with severe mental health problems
  • People with severe kidney or liver problems
  • People with severe heart problems
  • People who have or have had skin cancer (malignant melanoma)
  • People with an eye condition due to increased pressure in the eye causing blurred vision and pain (narrow angle or closed angle glaucoma)
  • Pregnant women or those trying to become pregnant
  • Women breast feeding
  • Adults under 25 years old
  • People taking or within 2 weeks of stopping treatment with, monoamine oxidase (MAO) non-selective inhibitors used to treat depression such as isocarboxazid or phenelzine

Also see list of precautions and interactions

STORAGE

Do not store above 25°C.
Store in the original package.
Keep bottle tightly closed

CO-BENELDOPA USES

What is it used for?

  • Co-beneldopa is a dopamine replacement therapy used to treat Parkinson's disease.
  • It is a dopaminergic drug.
  • It is used to treat Parkinson's disease. Co-beneldopa contains levodopa and benserazide (in a 4 to 1 ratio). People with Parkinson’s disease do not have enough dopamine in certain areas of their brain, which can result in slow movements, stiff muscles and tremor. Levodopa, one of the medicines in co-beneldopa, converts to dopamine, the active substance needed in the brain of people with Parkinson’s disease. Benserazide (a decarboxylase inhibitor) is combined with levodopa to reduce some of the side effects of levodopa in the rest of the body as it allows more of the levodopa to get into the brain.
  • In general this drug is used to treat people with Parkinson's disease.
  • Benefits of being on this drug can include an improvement in the symptoms of Parkinson's disease: slow movements, stiff muscles and tremor.

Listed below are the typical uses of Co-beneldopa.

  • Parkinson's disease (but not drug induced extrapyramidal Parkinsonism-like symptoms)
  • Parkinson's disease with on-off phenomenon; sudden stops and starts in your ability to move (controlled release tablets)

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

Co-beneldopa is available as oral capsules, controlled release oral capsules and oral dispersible tablets.

How often do I take it?

  • Take this medication by mouth usually in divided daily doses, with or after food as directed by your doctor. Controlled release tablets must be swallowed whole, with or without food and must not be crushed or chewed.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to a week before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication can cause excessive drowsiness or sudden onset of sleep. Do not drive or operate machinery until you are sure that you are not affected. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
  • You must not stop taking this medication abruptly as there is a risk of serious side effects if you do so. You may develop a condition known as neuroleptic malignant-like syndrome. Signs include increased shaking, high temperature, stiff muscles, balance problems, rapid heart rate and mental changes.
  • Talk to your doctor immediately as this is a life threatening condition.

CO-BENELDOPA SIDE EFFECTS

If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Allergic reactions such as rash and itching (see also serious allergic reaction below)
  • Changes in your heart beat
  • Blood in your faeces (stools) or in your vomit when you are sick (this can look like ground coffee) as this may be due to bleeding in your stomach or intestines.
  • An increase in the number of infections you are getting as this may be due to a reduction in the number of white blood cells
  • You feel tired and look pale as this may be due to a reduction in the number of red blood cells
  • You bruise more easily or get nose bleeds due to a reduction in the number of platelets in your blood.
  • High fever alone or in combination with stiff muscles, change in mental state, rapid breathing and rapid heart rate as these may be signs of a serious, but rare condition known as neuroleptic malignant syndrome.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

CO-BENELDOPA PRECAUTIONS

Before taking Co-beneldopa, tell your doctor or pharmacist if you are allergic to it; or to other dopaminergic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Known hypersensitivity to levodopa or benserazide or any of the other ingredients in the medication
  • An eye condition due to increased pressure in the eye causing blurred vision and pain (narrow angle or closed angle glaucoma)
  • Severe mental health problems
  • Severe kidney or liver problems
  • Severe heart problems
  • Or have had skin cancer (malignant melanoma)

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following Stomach ulcers

  • Severe lung disease
  • Soft bone disease (osteomalacia)
  • Endocrine disorders such as severe overactive thyroid gland, diabetes or adrenal tumour (phaeochromocytoma)
  • Epilepsy (fits) or history of convulsions
  • Mental health problems (avoid use if severe)
  • An eye condition due to increased pressure in the eye (open angle glaucoma) or at risk of angle closure glaucoma
  • Kidney or liver problems
  • Heart problems such as heart attack or abnormal heart rhythm

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect co-beneldopa.

The elderly: co-beneldopa can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Co-beneldopa is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Co-beneldopa is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

CO-BENELDOPA INTERACTIONS

Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with co-beneldopa:

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.

CO-BENELDOPA OVERDOSE

Taking too much Co-beneldopa, may cause the following: changes in your heart beat, confusion, difficulty sleeping, feeling or being sick and unusual movements of different parts of the body that you cannot control.

People who have taken too much Co-beneldopa, should talk to a doctor or go to a hospital straight away. Take the medicine pack with you.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of Co-beneldopa or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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