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Terms Of Use


Brand Name(s) : Paramol
Side Effects


Co-dydramol should be used with caution in:

It should not be used in:

  • People suffering an asthma attack
  • patients who are allergic to paracetamol, dihydrocodeine or other opioids, or any of the other ingredients
  • patients who suffer from breathing difficulties
  • obstructive airways disease
  • patients with diarrhoea caused by poisoning or severe bloody diarrhoea

Also see list of precautions and interactions


Store below 25°C in a dry place, protected from light.


Co-dydramol (paracetamol and dihydrocodeine) is used in the treatment of mild to moderate pain.

Co-dydramol is a combination of two painkillers, paracetamol and dihydrocodeine a weak opioid analgesic. It is important not to exceed the maximum daily dose of paracetamol. A number of over the counter medicines bought in pharmacies and shops contain paracetamol. Do not take other preparations containing paracetamol at the same time as co-dydramol.

Co-dydramol is used to relieve mild to moderate pain.

Benefits of being on this drug can include prevention of pain.

Listed below are the typical uses of co-dydramol.


How often do I take it?

  • Always take Co-dydramol tablets exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist.Swallow the tablets with water, during or after meals.
  • Use this medication for the duration of prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to 30 minutes to 2 hours before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Co-dydramol tablets may cause dizziness, blurred vision or the inability to think clearly. If you are affected do not drive or operate machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.


  • skin rash
  • blood disorders (including thrombocytopenia, leucopenia, neutropenia)
  • constipation
  • nausea
  • vertigo
  • headache
  • giddiness
  • low blood pressure (hypotension) with infusion
  • regular prolonged use leads to addiction and symptoms of restlessness and irritability may result when treatment is stopped. Prolonged use of a painkiller for headaches can make them worse
For details of other side effects see the information leaflet.

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing, increased sweating, redness or flushed face, mucosal lesions (such as mouth ulcers), drug fever.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking co-dydramol, tell your doctor or pharmacist if you are allergic to it; or to other analgesics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • asthma attacks
  • allergies to paracetamol, dihydrocodeine or other opioids, or any of the other ingredients
  • breathing difficulties
  • obstructive airways disease
  • diarrhoea caused by poisoning or severe bloody diarrhoea

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • allergic disorders
  • hyperthyroidism
  • kidney disease
  • liver disease
  • diseased adrenal glands (Addison’s disease)
  • high blood pressure caused by a tumour near a kidney (phaeochromocytoma)
  • inflammatory bowel disease
  • gall bladder disease or gall stones
  • recent surgery on your gastro-intestinal tract (stomach and intestine) or urinary system
  • enlarged prostate gland and difficulty urinating
  • epilepsy or head injury or raised pressure in the skull,
  • an underactive thyroid gland
  • muscle weakness (myasthenia gravis)
  • low blood pressure or are in shock
  • alcoholism, drug abuse or dependence or mental illness

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Do not drink alcohol while taking co-dydramol tablets.

The elderly: co-dydramol can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Co-dydramol is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Co-dydramol is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Monoamine Oxidase Inhibitors (MAOIs) such as moclobemide, linezolid, selegiline. Co-dydramol should not be taken for 2 weeks after stopping MAOIs.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • warfarin or other medications to prevent blood clotting
  • ciprofloxacin (antibacterial medicine)
  • oral contraceptives (the “pill”)
  • cyclizine, metoclopramide or domperidone (to prevent sickness)
  • guanethidine or diuretics (“water tablets”) e.g. spironolactone, furosemide (to treat high blood pressure)
  • mexiletine (to treat irregular heartbeats)
  • loperamide or kaolin (to treat diarrhoea)
  • selegiline (for Parkinson’s disease)
  • phenytoin (to treat epilepsy)
  • cimetidine (to treat stomach ulcers)
  • atropine or hyoscine (anticholinergic medicines)
  • ritonavir (antiviral medicine)
  • medicines which affect the nervous system such as sleeping tablets, diazepam, hydroxyzine and medicines to treat mental illness
  • medicines to treat depression (e.g. tranylcypromine, amitriptyline)
  • medicines which affect the liver (e.g. primidone and rifampicin)
  • colestyramine (to treat high cholesterol levels)
  • muscle relaxants
  • barbiturates (e.g. phenobarbital)
  • anaesthetics
  • opioid antagonists (buprenorphine, naltrexone, naloxone)

This information does not contain all possible interactions. Therefore, before using co-dydramol, tell your doctor or pharmacist of all the products you use.


Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of co-dydramol or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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