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Terms Of Use

COLCHICINE

Brand Name(s) : None
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

COLCHICINE WARNINGS

Colchicine should be used with caution in: elderly patients and debilitated patients and to those with cardiac, renal (kidney), hepatic (liver) or gastrointestinal disease.

It should not be used in: patients who are allergic to colchicine, children under 12 years of age, patients with blood problems, those undergoing haemodialysis, patients with severe liver disease or severe kidney disease, pregnancy, people suffering from kidney or liver problems and taking a certain type of drugs (see interactions)

Also see list of precautions and interactions

STORAGE

Store below 25-30°C (depending on brand) and protect from light.

COLCHICINE USES

What is it used for?

  • Colchicine is used to treat gout.
  • It is an analgesic (pain relieving) drug.
  • In general this drug is used to treat acute gout and helps prevent gout (high levels of uric acid in the bloodstream) during initial therapy with drugs (allopurinol, probenecid and sulfinpyrazone) that affect the levels of uric acid in the blood.
  • Benefits of being on this drug can include prevention of a gout attack (if used regularly).

Listed below are the typical uses of colchicine:

  • For the treatment of acute gout
  • For the prophylaxis (prevention) of recurrent gout
  • Prevent acute attacks during the initial treatment with allopurinol or uricosuric drugs.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • For treatment of acute gout: an increasing dose as prescribed by your doctor
  • For prevention of attacks: a regular dose two or three times daily.
  • Use this medication for duration of prescription in order to get the most benefit from it. Your doctor will tell you how soon you can take another dose, how long to wait between doses and how many tablets you can take for each gout attack.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • For the treatment of acute gout, you should wait at least 3 days before starting another course of colchicine tablets.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • None stated. Consult your doctor or pharmacist for more details.

When can I stop?

  • For the treatment of acute gout: stop taking this medication when the pain is gone, when you have upset stomach/diarrhoea, or when you reach the limit on the number of tablets you should take.
  • For the prevention of gout attacks: take the medicine regularly and do not stop unless told to by your doctor.

COLCHICINE SIDE EFFECTS

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain

Excessive doses may also cause:

  • Profuse diarrhoea
  • Gastro-intestinal haemorrhage
  • Muscle weakness
  • Rashes
  • Renal and hepatic damage

If any of these persist or you consider them severe then stop taking this medication and inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms: hair loss, decreased appetite, mouth sores, difficulty urinating/incontinence (bladder spasms), constipation, signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, yellowing of eyes/skin, fatigue, dark urine, change in the amount of urine, pink/red urine, fatigue, muscle tenderness/pain, numbness/tingling of arms or legs.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

COLCHICINE PRECAUTIONS

Before taking Colchicine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver disease, severe kidney disease, blood problems, having haemodialysis.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following heart problems, kidney problems, digestive problems.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect colchicine.

The elderly: colchicine should be used with caution in the elderly as kidney function declines as you grow older and this medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug, especially muscle problems.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Colchicine is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Colchicine passes into breast milk. It should not be taken whilst breastfeeding, unless your doctor thinks it is necessary.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

COLCHICINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications in people who have kidney or liver impairment because very serious, possibly fatal interactions may occur:

  • Clarithromycin, erythromycin or telithromycin
  • Ritonavir, atazanavir or indinavir
  • Ciclosporin
  • Ketoconazole or itraconazole
  • Verapamil or diltiazem
  • Quinidine

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Certain macrolide antibiotics (e.g. clarithromycin, erythromycin)
  • Ciclosporine
  • Statins e.g. fluvastatin
  • Amiodarone
  • Vitamin B12 (cyanocobalamin)
  • Digoxin

This information does not contain all possible interactions. Therefore, before using colchicine, tell your doctor or pharmacist of all the products you use.

COLCHICINE OVERDOSE

An overdose of colchicine may cause: bloody diarrhoea, blood in the urine, change in the amount of urine, muscle weakness, seizures, and confusion.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of colchicine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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