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DOXAZOSIN

Brand Name(s) : Cardura, Doxadura, Cardura XL, Doxadura XL
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

DOXAZOSIN WARNINGS

Doxazosin should be used with caution in:

  • People with liver disease
  • People using PDE-5 inhibitors (used to treat impotence in men)
  • People undergoing eye surgery for cataracts
  • People susceptible to heart failure
  • People with other hear problems
  • People at the start of your treatment, due to faintness or dizziness caused by low blood pressure when getting up from sitting or lying down
  • People who are pregnant or trying to become pregnant

It should not be used in:

  • People who have had an allergic reaction to doxazosin, other types of quinazolines (such as prazosin or terazosin) or any other ingredient in the medicine
  • Breastfeeding mothers
  • People under 16 years of age
  • People who have an enlarged prostate gland and have low blood pressure
  • People who had a condition called orthostatic hypotension, a form of low blood pressure that happens when standing up from sitting or lying down
  • People with an enlarged prostate gland with any of the following: any blockage in the urinary tract, chronic urinary tract infection or bladder stones
  • People who do not feel the urge to urinate or have anuria where the body is not producing any urine

Also see list of precautions and interactions

STORAGE

Do not store above 25ºC. Storage recommendations from different manufacturers may vary, please check Patient Information Leaflet for details.

DOXAZOSIN USES

Doxazosin is used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (enlargement of the prostate gland).

It is an alpha-adrenoceptor blocking drug, sometimes known as alpha-blockers.

It is used to control blood pressure in patients with hypertension and to treat urinary outflow obstruction in patients with benign prostatic hyperplasia.

In general this drug is used to treat high blood pressure and to treat poor and/or frequent passing of urine in patients with an enlarged prostate gland.

Benefits of being on this drug can include lowered blood pressure and relief from symptoms of benign prostatic hyperplasia.

Listed below are the typical uses of doxazosin.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally usually once daily, morning or evening with a glass of water.
  • Modified release tablets should be taken whole and should not be crushed or chewed
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Take care if you drive or operate machinery, as your tablets may make you feel weak or dizzy and affect your ability to drive or operate machinery safely, particularly when you first start taking them. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

DOXAZOSIN SIDE EFFECTS

  • ringing or noise in the ears
  • vertigo (feeling of spinning or rotation of surroundings)
  • stomach/abdominal pains
  • dry mouth
  • loss of appetite
  • constipation
  • diarrhoea
  • feeling/being sick
  • indigestion
  • heartburn and wind
  • general weakness or feeling unwell
  • swelling of feet or lower legs
  • tiredness
  • pain
  • muscle cramps
  • headache
  • dizziness
  • tingling
  • reduced or altered sensitivity of the hands and feet
  • tremor
  • sleepiness
  • fainting,
  • cough
  • wheeze
  • shortness of breath
  • nose bleeds
  • nasal stuffiness
  • sneezing and/or runny nose caused by inflammation of the lining of the nose (rhinitis)
  • hair loss
  • skin rash including hives
  • itching
  • red or purple patches on the skin
  • bleeding under the skin
  • disorder in passing urine (including pain on passing urine, increased volume of urine passed, needing to pass urine at night and increased number of times of passing urine)
  • urinary incontinence
  • blood in urine
  • low blood pressure
  • faintness or dizziness caused by low blood pressure when getting up from a sitting or lying position
  • hot flushes
  • low numbers of white blood cells or blood platelets, which may result in bruising or easy bleeding
  • blurred vision
  • jaundice
  • hepatitis (liver inflammation)
  • bile disorder
  • allergic reaction
  • weight gain
  • liver enzyme increases
  • loss of appetite
  • sleeplessness
  • agitation
  • anxiety
  • depression
  • nervousness
  • discomfort or enlargement of the breasts in men
  • painful persistent erection of the penis
  • failure/ inability to achieve penile erection
  • little or no semen ejaculated at sexual climax
  • cloudy urine following sexual climax

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Stop taking doxazosin and tell your doctor immediately if you develop any of the following symptoms:
swelling of the face, tongue or windpipe; chest pain, angina, increased, decreased or irregular heart beat, palpitations, heart attack or stroke.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

DOXAZOSIN PRECAUTIONS

Before taking Doxazosin, tell your doctor or pharmacist if you are allergic to it; or to other alpha-blockers; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you: are breastfeeding; have an enlarged prostate gland and have low blood pressure; had a condition called orthostatic hypotension in the past; have an enlarged prostate gland with any of the following: any blockage in the urinary tract, chronic urinary tract infection or bladder stones; do not feel the urge to urinate or have anuria where the body is not producing any urine.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: erectile dysfunction, heart problems, liver problems, you are due to have eye surgery for cataracts, if you are pregnant or trying to become pregnant.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Alcohol intake does not appear to affect this drug.

The elderly: doxazosin can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of using doxazosin during pregnancy has not been established. If you are pregnant or trying to become pregnant speak to your doctor to discuss if doxazosin is suitable for you.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Doxazosin is not safe to take if you are breastfeeding

Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

DOXAZOSIN INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:
PDE-5 inhibitors used to treat erectile dysfunction, such as sildenafil, tadalafil, vardenafil

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other medicines used to treat high blood pressure: ACE inhibitors (eg. Ramipril), beta blockers (e.g. bisoprolol), calcium channel blockers (e.g. nifedipine), diuretics (water tablets)
  • Oestrogens
  • Dopamine, ephedrine, adrenaline
  • Monoamine oxidase inhibitors (MAO’s) used to treat depression
  • NSAIDs (non-steroidal anti-inflammatory drugs) e.g. ibuprofen

This information does not contain all possible interactions. Therefore, before using Doxazosin, tell your doctor or pharmacist of all the products you use.

DOXAZOSIN OVERDOSE

If several tablets are taken it may be dangerous. Tell your doctor immediately or go to your nearest hospital casualty department.
Should overdosage lead to hypotension (low blood pressure that may cause dizziness and fainting), the patient should be immediately placed lying down, in a head down position.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of doxazosin or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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