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Terms Of Use

DUTASTERIDE

Brand Name(s) : Avodart
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

DUTASTERIDE WARNINGS

Dutasteride should be used with caution in: mild to moderate liver disease, patients who are about to have a blood test for prostate-specific antigen (PSA).

It should not be used in: children, adolescents, women, patients who are allergic to dutasteride, other 5-alpha reductase inhibitors, or to any other ingredients in the medicine, severe liver disease.

Also see list of precautions and interactions

STORAGE

Do not store above 30ºC.

DUTASTERIDE USES

What is it used for?

  • Dutasteride is used to treat men with an enlarged prostate (benign prostatic hyperplasia).
  • It is a 5-alpha reductase inhibitor, sometimes known as a hormone antagonist.
  • It is used to lower the production of the hormone dihydrotestosterone. An enlarged non-cancerous growth of the prostate (benign prostatic hyperplasia) can be caused by the production of too much dihydrotestosterone. As the prostate grows it can cause difficulty passing urine (water) or a need to pass urine more frequently. The flow of urine may also be slower and less forceful. By reducing the production of dihydrotestosterone, dutasteride helps to shrink the prostate and relieve associated symptoms.
  • In general this drug is used to treat an enlarged prostate.
  • Benefits of being on this drug can include helping to shrink the prostate, making it easier and less painful to pass urine (water). Dutasteride also reduces the risk that your urine flow will be completely blocked (acute urinary retention) and the need for prostate surgery.

Listed below are the typical uses of dutasteride.

  • To treat moderate to severe symptoms associated with an enlarged prostate (benign prostatic hyperplasia)
  • To reduce the risk of acute urinary retention and surgery in patients with an enlarged prostate.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth usually once a day, with or without food. Swallow the capsules whole with water. Do not chew or break open the capsules.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take up to 6 months or more before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Dutasteride is unlikely to affect your ability to drive or operate machinery. You should avoid unprotected sexual intercourse. Always wear a condom during sexual intercourse as dutasteride has been found in the semen of men taking the medicine. Women, children and adolescents must not handle leaking dutasteride capsules because the medicine can be absorbed through the skin. If contact with the skin occurs, wash the affected area with soap and water. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

DUTASTERIDE SIDE EFFECTS

  • Impotence (unable to achieve or maintain an erection)
  • Decreased sex drive
  • Difficulty with ejaculation
  • Breast enlargement or tenderness
  • Reduction in sperm count
  • Dizziness (when used with the medicine tamsulosin)
  • Sore mouth or throat if you mouth comes into contact with the contents of the capsule.

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Skin rash which may be itchy, hives like a nettle rash, swelling of the eyelids, lips, face, arms or legs.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

DUTASTERIDE PRECAUTIONS

Before taking dutasteride, tell your doctor or pharmacist if you are allergic to it; or to other 5-alpha reductase inhibitors; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: an allergy to dutasteride, other 5-alpha reductase inhibitors, or to any other ingredients in the medicine, severe liver disease.

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following mild to moderate liver disease, you are about to have a blood test for prostate-specific antigen (PSA).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect dutasteride.

The elderly: dutasteride can be used by the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Dutasteride is for men only and should not be taken by women. However, if you are pregnant or think you may be pregnant you must not handle dutasteride capsules that are leaking as the medicine can be absorbed though the skin and may harm your unborn baby. Dutasteride is also found in the semen of men taking the medicine. Therefore, if you are pregnant and your partner is taking dutasteride you should not be exposed to his semen - always use a condom during sexual intercourse.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Dutasteride is only for male patients.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

DUTASTERIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

This information does not contain all possible interactions. Therefore, before using dutasteride, tell your doctor or pharmacist of all the products you use.

DUTASTERIDE OVERDOSE

Taking too much dutasteride may cause the following: impotence (unable to achieve or maintain an erection), decreased sex drive, difficulty with ejaculation, breast enlargement or tenderness.

People who have taken too much dutasteride should contact their doctor or pharmacist. If a pregnant women has come into contact with dutasteride, contact a doctor for advice.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of dutasteride or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you forget to take dutasteride, don't take extra capsules to make up for a missed dose. Just take your next dose at the usual time.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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