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Terms Of Use

EPLERENONE

Brand Name(s) : Inspra
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

EPLERENONE WARNINGS

Eplerenone should be used with caution in:

  • patients with kidney or liver disease, those taking lithium (generally given for bipolar disorder), and those taking tacrolimus or ciclosporin (used to prevent organ rejection after a transplant or treat skin conditions such eczema).

It should not be used in:

  • patients who are allergic (hypersensitive) to eplerenone or to any other ingredients in the medication (such as lactose), patients who have high levels of potassium in the blood (hyperkalaemia), those with moderate to severe kidney disease, those with severe liver disease, children, patients taking medicines for fungal infection (ketoconazole or itraconazole), antiviral medication for HIV (nelfinavir or ritonavir), antibiotics (clarithromycin or telithromycin), nefazodone for depression, or drugs to help the body excrete excess fluid such as potassium sparing diuretics and 'salt tablets' (potassium supplements).

Also see list of precautions and interactions.

STORAGE

No specific storage instructions.

EPLERENONE USES

What is it used for?

  • Eplerenone is used to prevent worsening heart failure after a heart attack.
  • It is a selective aldosterone blocker. This group of drugs work by inhibiting the action of aldosterone, a hormone that controls blood pressure and heart function. High levels of aldosterone can cause changes that lead to heart failure.
  • In general this drug is used in combination with another drug (typically a beta-blocker or diuretic [water tablet]) after a heart attack to prevent worsening heart failure.
  • Benefits of being on this drug can include prolonging life and reducing the likelihood of heart or circulatory problems.

Listed below are the typical uses of eplerenone:

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth, with food or on an empty stomach. Swallow the tablets whole with plenty of water.
  • Tablets are normally taken once a day. The strength of the tablets may be increased by your doctor.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • Dosage is based on your age, medical condition, response to therapy, and use of certain interacting medicines.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • You may feel dizzy after taking eplerenone. If this is the case, do not drive or operate machinery. Eplerenone tablets contain lactose, a sugar. If you have been told by your doctor that you are intolerant to certain sugars, contact your doctor before starting treatment. The following medications should also be avoided: medicines for fungal infection (ketoconazole or itraconazole), antiviral medication for HIV (nelfinavir or ritonavir), antibiotics (clarithromycin or telithromycin), nefazodone for depression, or drugs to help the body excrete excess fluid such as potassium sparing diuretics and "salt tablets" (potassium supplements).

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
    Always complete the full course as prescribed by your doctor.

EPLERENONE SIDE EFFECTS

  • Increased potassium level in the blood (symptoms include muscular cramps, diarrhoea, nausea, dizziness or headache)
  • Dizziness
  • Low blood pressure
  • Diarrhoea
  • Nausea (feeling sick)
  • Rash
  • Raised levels of certain white blood cells
  • Dehydration
  • Increased levels of cholesterol or fats in your blood
  • Insomnia
  • Headache
  • Irregular heartbeat
  • Heart attack
  • Heart failure
  • Low blood pressure that can cause dizziness upon standing
  • Thrombosis (blood clot) in the leg
  • Sore throat
  • Wind
  • Vomiting (being sick)
  • Itching
  • Back pain
  • Leg cramps
  • General weakness and feeling unwell
  • Increased levels of certain proteins (urea and creatinine) in the blood, which could be due to kidney problems
  • Enlarged breasts in men

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

EPLERENONE PRECAUTIONS

Before taking eplerenone, tell your doctor or pharmacist if you are allergic to it; or to other selective aldosterone blocking agents; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: high levels of potassium in the blood (hyperkalaemia), moderate to severe kidney disease, severe liver disease.

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following: kidney or liver disease.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect this drug

The elderly: eplerenone can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of eplerenone has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether eplerenone passes into breast-milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

EPLERENONE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • medicines for fungal infection (ketoconazole or itraconazole), antiviral medication for HIV (nelfinavir or ritonavir), antibiotics (clarithromycin or telithromycin), nefazodone for depression, or drugs to help the body excrete excess fluid such as potassium sparing diuretics and 'salt tablets' (potassium supplements).

If you are currently using any such medicine, tell your doctor or pharmacist before starting eplerenone.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • lithium (usually prescribed for bipolar disorder),
  • cyclosporin or tacrolimus (used for skin conditions such as eczema, and to prevent organ rejection after a transplant),
  • non-steroidal anti-inflammatory drugs or NSAIDs (such as ibuprofen, used to relieve pain, stiffness and inflammation),
  • trimethoprim (for bacterial infections),
  • heart disease or particular kidney conditions,
  • ACE inhibitors (such as enalapril) and angiotensin II receptor antagonists (such as candesartan) used for high blood pressure,
  • alpha I blockers, such as prazosin , used to treat high blood pressure and some prostate conditions,
  • tricyclic antidepressants such as amitriptyline,
  • antipsychotics (also known as neuroleptics for the treatment of psychiatric disorders) such as chlorpromazine,
  • amifostine (used in cancer chemotherapy),
  • baclofen (used to treat muscle spasm),
  • glucocorticoids, such as hydrocortisone or prednisone (used certain skin conditions) and tetracosactide (mainly used for diagnosing and treating disorders of the adrenal cortex) ,
  • warfarin (an anti-clotting drug),
  • digoxin (used in the treatment of heart conditions),
  • erythromycin (for bacterial infections),
  • saquinavir (an antiviral for HIV),
  • fluconazole (for fungal infections),
  • amiodarone,
  • diltiazem and verapamil (for heart problems and high blood pressure),
  • St rifampicin (for bacterial infections),
  • carbamazepine,
  • phenytoin,
  • phenobarbital (used for epilepsy and other conditions),
  • John's Wort (herbal medicinal product).

This information does not contain all possible interactions. Therefore, before using eplerenone, tell your doctor or pharmacist of all the products you use.

EPLERENONE OVERDOSE

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of eplerenone or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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