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Terms Of Use

FLUCONAZOLE

Brand Name(s) : Canesten Oral, Diflucan
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

FLUCONAZOLE WARNINGS

Fluconazole should be used with caution in: pregnant women and women who are breastfeeding, children under 16 years of age, those with liver or kidney problems, heart disease (including heart rhythm problems), or have abnormal blood levels of potassium, calcium or magnesium.

It should not be used in: those with a blood disorder called acute porphyria.

Also see list of precautions and interactions.

STORAGE

Store below 25°C. Do not freeze reconstituted suspension or intravenous infusion.

FLUCONAZOLE USES

What is it used for?

  • Fluconazole is used to treat a number of problems.
  • It is a triazole antifungal agent, and is sometimes known as an antifungal drug.
  • It is used to treat infections caused by fungi in many different parts of the body.
  • In general this drug is used to treat infections caused by fungi, including yeasts. The most common cause of fungal infections is a yeast called candida, which causes genital thrush (a yeast infection of the vagina or penis), which can be treated with fluconazole. It is also used to treat a variety of other fungal infections.
  • Benefits of being on this drug can include eradication and resolution of fungal infections, allowing recovery and relief of symptoms such as pain, itching or cough caused by the infection.

Listed below are the typical uses of fluconazole.

  • The treatment of vaginitis caused by candida infection
  • The treatment of sexual partners with associated candidal balanitis (an inflammation of the head of the penis, sometimes called penis thrush)
  • Treating candida infections in other parts of the body, including a general (systemic) infection
  • The prevention of fungal infections in immunocompromised patients, such as those with AIDS
  • Treatment of cryptococcosis infection (a serious and often life-threatening fungal infection, common in patients with AIDS, which can cause infection of the skin, lungs or cryptococcal meningitis [an infection of the meninges, the tissue covering the brain]).

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth, usually once daily, with or without a meal at any time of day. Tablets should be taken with a glass of water. It is also available as a powder to be suspended in water and taken by mouth, and as a liquid for intravenous infusion (when given by a doctor or other healthcare worker).
  • Use this medication for the duration of the prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • None known. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.

FLUCONAZOLE SIDE EFFECTS

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms: any heart problems, yellowing of the skin or eyes (jaundice), or seizures.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

FLUCONAZOLE PRECAUTIONS

Before taking fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other antifungal drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: a blood disorder called acute porphyria.

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following: a history of liver or kidney problems, heart disease (including heart rhythm problems), or abnormal blood levels of potassium, calcium or magnesium.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • It is not known whether drinking alcohol affects this drug's action.

The elderly: fluconazole should be used with caution in the elderly as this group may be more likely to have kidney problems than younger patients and this drug is excreted mainly in urine.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Fluconazole is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Fluconazole is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

FLUCONAZOLE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Antidepressants (reboxetine)
  • Anti-malarials (artemether/lumefantrine)
  • Anti-psychotics (pimozide or sertindole)
  • Terfenadine
  • Cisapride
  • Antihypertensives (bosentan or nisoldipine)
  • Ergotamine or methysergide, used to treat migraine.

If you are currently using any such medicine, tell your doctor or pharmacist before starting fluconazole.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other antifungals (e.g. amphotericin)
  • Immunosuppressants (e.g. ciclosporin or tacrolimus)
  • Blood-thinning drugs (e.g. warfarin)
  • Anti-bacterials (e.g. rifabutin or rifampicin)
  • Anti-epileptics (e.g. phenytoin)
  • Antivirals (e.g. nevirapine, zidovudine, ritonavir or tipranavir)
  • Sedatives (e.g. midazolam)
  • Anti-arrhythmics (e.g. digoxin)
  • Diuretics (e.g. hydrochlorothiazide)
  • Lipid-regulating drugs (e.g. fluvastatin, atorvastatin or simvastatin)
  • Theophylline, used to treat asthma
  • Antidiabetics (e.g. chlorpropamide, glibenclamide, glipizide or tolbutamide).

This information does not contain all possible interactions. Therefore, before using fluconazole, tell your doctor or pharmacist of all the products you use.

FLUCONAZOLE OVERDOSE

Taking too much fluconazole may cause the following: hallucinations (seeing or hearing things that are not there) and paranoid behaviour (fear or anxiety that is irrational).

People who have taken too much fluconazole should seek assistance from a healthcare professional.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of co-trimoxazole or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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