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Terms Of Use

GLIPIZIDE

Brand Name(s) : Minodiab
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

GLIPIZIDE WARNINGS

Glipizide should be used with caution in:

  • Elderly
  • People with decreased kidney function
  • People with decreased liver function
  • People in stressful situations such as fever, infection, injury or surgery
  • People lacking an enzyme in the blood known as glucose-6-phosphate dehydrogenase (G6PD)
  • People with adrenal gland problems
  • People with pituitary gland problems
  • People with a poor diet, irregular meal habits or suffering from malnutrition
  • People drinking alcohol, particularly if a meal is skipped
  • People taking certain medications to treat high blood pressure, infections and other conditions (see interactions)

This medication may lead to low blood sugar levels when meals are taken at irregular hours or if you take more exercise than normal. The symptoms of low blood sugar include headache, excessive hunger, nausea, vomiting, tiredness, sleepiness, feeling restless, feeling aggressive, difficulty in concentrating, tremor, confusion, speech and sight problems. It is important to take some form of sugar as soon as possible to prevent your blood sugar level dropping any further.

It should not be used in:

  • Children (under 18 years)
  • People with an allergy to glipizide or any of the ingredients in the medicine
  • People with insulin dependent diabetes (type 1 diabetes)
  • People with severe liver problems
  • People with severe kidney problems
  • People with thyroid problems
  • People in a diabetic pre-coma or coma
  • People with diabetic ketoacidosis (complication of diabetes with body producing ketone bodies)
  • Pregnant women
  • Women breastfeeding
  • Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (as the tablets contain lactose)
  • People taking miconazole (used to treat fungal infections)

Also see list of precautions and interactions

STORAGE

Keep in a cool place (below 25°C).

GLIPIZIDE USES

What is it used for?

  • Glipizide is used to treat type 2 diabetes mellitus.
  • It is a sulfonylurea, sometimes known as an oral hypoglycaemic.
  • It is used to control blood sugar levels in people with type 2 diabetes. People with type 2 diabetes do not normally require insulin (non-insulin dependent) and glipizide is used when diet and exercise have not sufficiently controlled the blood sugar levels. Glipizide mainly acts by stimulating the release of insulin.
  • In general this drug is used treat type 2 diabetes in adults by controlling the blood sugar levels.
  • Benefits of being on this drug can include better control of blood sugar levels thus reducing the risk of complications. Good control of blood sugar levels over 24 hours can be achieved following a single daily dose.

Listed below are the typical uses of glipizide.

  • Type 2 (non-insulin dependent) diabetes, when diet and exercise alone are not sufficient to control blood sugar levels.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • None known.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth usually once daily, preferably 30 minutes before breakfast or the first main meal of the day. Follow your doctor's instructions carefully.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to a few hours before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines. The dose of glipizide taken is determined by the blood and urinary glucose levels.

Do I need to avoid anything?

  • If you have low or high blood sugar levels, or you have visual problems, then avoid driving or operating machinery. It is important that take extra care to avoid low blood sugar levels when driving and that you pay attention to the warning signs of low blood sugar. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
  • Do not stop taking this medication or change your dosage without seeing your doctor. Stopping this medication may make your diabetes worse.

GLIPIZIDE SIDE EFFECTS

  • Visual disturbances
  • Blood abnormalities
    - Decreases in white blood cell count (more likely to get an infection)
    - Decreases in platelet count (more likely to bruise and bleed)
    - Decreases in red blood cell count (look pale and feel tired)
  • Low blood sugar (hypoglycaemia)
  • Increases in liver enzymes
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Stomach ache
  • Allergic skin reactions such as rash, itching, hives or increased sensitivity to sunlight
  • Abnormal liver function
    - Inflammation of the liver (hepatitis)
    - Yellowing of the skin and eyes (jaundice)
    - Bile flow problems (cholestasis)
  • Decreases in blood sodium level
  • Very low blood sugar levels (severe hypoglycaemia) with fits, loss of consciousness or coma

If any of these persist or you consider them severe then inform doctor or pharmacist.

Glipizide can lead to low blood sugar (hypoglycaemia). The symptoms of low blood sugar include headache, excessive hunger, nausea, vomiting, tiredness, sleepiness, feeling restless, feeling aggressive, difficulty in concentrating, tremor, confusion, speech and sight problems.

Tell your doctor immediately if you develop any of the following symptoms:

  • Yellowing of eyes and skin (signs of liver problems)
  • Skin rash, itching hives or increased sensitivity to sunlight as mild allergic reactions can progress into more serious allergic reactions
  • Severely low blood sugar with fits, loss of consciousness or coma

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website

GLIPIZIDE PRECAUTIONS

Before taking glipizide, tell your doctor or pharmacist if you are allergic to it; or to other sulfonylureas; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Allergy to glipizide or any of the ingredients in the medication
  • Severe liver problems
  • Severe kidney problems
  • Thyroid problems
  • Diabetic pre-coma or coma
  • Diabetic ketoacidosis (complication of diabetes with body producing ketone bodies)
  • Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (as the tablets contain lactose)

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Decreased kidney function
  • Decreased liver function
  • Adrenal gland or pituitary gland problems
  • Ongoing stressful situations such as fever, infection, injury or surgery
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency (an enzyme in the blood)
  • Poor diet, irregular meal habits or malnutrition

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol can reduce the blood sugar levels and also make you less aware of any blood sugar problems, so try and avoid drinking alcohol.

The elderly: glipizide should be used with caution in the elderly as it may increase the risk of hypoglycaemia (low blood sugar levels).

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

You should not take glipizide if you are, or are planning to become, pregnant. During pregnancy, it is preferred to control diabetes through the use of insulin.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

You should not take glipizide if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

GLIPIZIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Miconazole (used to treat fungal infections)

If you are currently using any of these medications, tell your doctor or pharmacist before starting glipizide.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:
Medications taken with glipizide which increase the risk of low blood sugar (hypoglycaemia). These include the following:

  • ACE inhibitors to treat high blood pressure and some heart problems such as captopril
  • Beta-blockers used to treat high blood pressure and some heart problems such as propranolol
  • Cimetidine and other H2 antagonists (for ulcers and indigestion)
  • Coumarins to stop blood clotting such as warfarin
  • Fibrates used to treat for high cholesterol such as clofibrate
  • Medications to treat bacterial infections such as chloramphenicol and sulphonamides (e.g. sulfamethoxazole or antibiotics containing sulphonamides e.g. co-trimoxazole)
  • Medications to treat fungal infections such as fluconazole, posaconazole and voriconazole
  • Medications used to treat gout such as allopurinol, probenecid and sulfinpyrazone
  • Monoamine oxidase inhibitors (MAOIs) used to treat depression such as moclobemide and phenelzine
  • Non-steroidal anti-inflammatory drugs (NSAIDs) and salicylates to treat pain and/or inflammation such as aspirin, ibuprofen and naproxen

Medications taken with glipizide which increase the risk of high blood sugar (hyperglycaemia). These include the following:

  • Adrenaline, noradrenaline and sympathomimetics (e.g. terbutaline, salbutamol used to treat asthma)
  • Corticosteroids used to treat allergies and inflammation such as hydrocortisone, prednisolone
  • Danazol (a hormone treatment for endometriosis)
  • Medications used to treat epilepsy such as phenytoin
  • Medications used to treat high blood pressure and other heart problems such as diazoxide, calcium antagonists e.g. nifedipine, verapamil and diuretics (water tablets), particularly thiazide diuretics e.g. bendroflumethiazide
  • Nicotinic acid (used to lower cholesterol)
  • Oestrogens and progestogens (e.g. oral contraceptives, hormone replacement therapy)
  • Phenothiazines used to treat psychoses (severe mental health problems) such as chlorpromazine
  • Rifampicin, isoniazid (antibiotics used to treat tuberculosis)
  • Thyroid hormones

The warning signs of low blood sugar can be masked by some medications including beta-blockers.

This information does not contain all possible interactions. Therefore, before using glipizide, tell your doctor or pharmacist of all the products you use.

GLIPIZIDE OVERDOSE

If you (or someone else) swallow a lot of the tablets at the same time, or if you think a child has swallowed any of the tablets, contact your nearest hospital casualty department or your doctor immediately.

An overdose of glipizide may cause feeling or being sick, sweating, fast breathing, fast heart rate, feeling faint or dizziness or drowsiness.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of glipizide or intentional overdose is suspected, contact your local hospital, GP or if in England call 111 or NHS Direct. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you forget to take a tablet, take one as soon as you remember, unless it is nearly time to take the next one. Never take two doses together. Take the remaining doses at the correct time.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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