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Terms Of Use

INDAPAMIDE

Brand Name(s) : Natrilix, Natrilix SR, Ethibide XL
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

INDAPAMIDE WARNINGS

Indapamide should be used with caution in:

  • Liver problems
  • Kidney problems
  • Diabetes
  • Gout
  • Heart disease, heart failure or problems with the heart beat
  • Elderly
  • Malnutrition (under-fed)
  • Hereditary blood disorders called acute porphyrias
  • A condition called systemic lupus erythematosus that causes inflammation and tissue damage in various parts of the body
  • A condition called hyperaldosteronism that is due to over-production of aldosterone, a hormone that controls salt and water balance in the body

It should not be used in:

  • Allergy (hypersensitivity) to indapamide, sulfonamides or to any of the other ingredients in the tablet
  • Severe liver problems
  • Severe kidney problems
  • When parathryoid function is being investigated
  • When there are low levels of potassium in the blood (hypokalaemia)

Also see list of precautions and interactions

STORAGE

No special storage conditions are required.

INDAPAMIDE USES

What is it used for?

  • Indapamide is used to treat high blood pressure (essential hypertension).
  • It is a type of diuretic, sometimes knows as water tablets.
  • It is used to lower your blood pressure by increasing the production of urine, thereby removing excess fluid from the body.

Listed below are the typical uses of indapamide:

HOW TO USE/TAKE

How often do I take it?

  • Take one tablet of indapamide each day, preferably in the morning, with or after food or on an empty stomach.
  • Modified release tablets should be swallowed whole and should not be crushed or chewed.

Use this medication for the duration of the prescription in order to get the most benefit from it.

Remember to use it at the same time each day - unless specifically told otherwise by your doctor.

What dose?

  • The dose is one tablet each day.

Do I need to avoid anything?

  • Indapamide may make you feel light-headed and dizzy when you first start to use it or when you begin to take an additional drug for high blood pressure. If this happens, do not drive or operate machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.

INDAPAMIDE SIDE EFFECTS

  • Low potassium in the blood
  • An allergic (hypersensitive) reaction, particularly in those who already have other allergies or asthma
  • Vomiting (being sick)
  • Nausea (feeling sick)
  • Dizziness
  • Tiredness
  • Headache
  • A sensation of pins and needles
  • Dry mouth
  • Constipation (passing of stools less frequently; hard, dry stools)
  • An increased risk of bleeding or bruising
  • Blood disorders that increase the risk of bleeding, bruising or catching an infection
  • Low blood pressure, which may cause dizziness and light-headedness
  • Liver problems
  • Kidney problems
  • Increases in the levels of calcium in the blood
  • Inflammation of the pancreas (pancreatitis)
  • Irregular heart beat
  • Impotence
  • A change in the appearance of your skin after exposure to the sun (photosensitivity)

If any of these persist or you consider them severe then tell your doctor as soon as possible.

Tell your doctor immediately if you develop any of the following symptoms:

  • Swelling of the face, lips or tongue
  • Swelling of the throat or airways, causing shortness of breath or difficulty swallowing
  • Unexplained fever, a sore throat or other flu-like symptoms
  • Blistering of the skin, mouth, eyes and genital organs
  • Thirst, lethargy, confusion, weakness, drowsiness, muscle cramps, abnormal heart beat, seizures, greatly reduced production of urine, nausea and vomiting

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

INDAPAMIDE PRECAUTIONS

Before taking indapamide, tell your doctor or pharmacist if you are allergic to it; or to other diuretics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Severe kidney problems
  • Severe liver problems
  • Low levels of potassium in your blood (hypokalaemia)
  • Rare hereditary blood problems

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Changes to the appearance of your skin after exposure to the sun (photosensitivity)

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake does not affect this drug.

The elderly: indapamide should be used with caution in the elderly as they are at greater risk of developing low levels of potassium in the blood.

Malnourished (under-fed). Indapamide should be used with caution in those who are malnourished as they are at greater risk of developing low levels of potassium in the blood.

Heart problems. Indapamide should be used with caution in those with heart conditions as they are at greater risk of developing an irregularity with their heart beat due to low levels of potassium in the blood. In addition, low levels of potassium increase the toxicity of digoxin, a common heart drug.

Liver problems. Indapamide should be used with caution in those with liver problems as they are at greater risk of developing low levels of potassium in the blood and a complication of liver disorders that damages the brain and nervous system (hepatic encephalopathy).

Gout. Indapamide should be used with caution in those who are tend to get gout as the number of gout attacks may be increased.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Indapamide is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Indapamide is not safe to take if you are breastfeeding

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

INDAPAMIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

If you are currently using any of these medications, tell your doctor or pharmacist before starting indapamide:

  • Drugs used to control an irregular heart beat
  • Drugs used to treat mental disorders
  • Bepridil to treat angina
  • Cisapride
  • Diphemanil
  • Sparfloxacin, moxifloxacin (antibiotics)
  • Halofantrine
  • Pentamidine
  • Mizolastine
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Angiotensin-converting enzyme (ACE) inhibitors
  • Oral corticosteroids
  • Stimulant laxatives
  • Baclofen
  • Potassium-sparing diuretics (e.g. amiloride, spironolactone, triamterene)
  • Metformin used to treat diabetes
  • Iodinated contrast media (used in tests involving X-rays)
  • Calcium tablets or other calcium supplements
  • Ciclosporin, tacrolimus or other medicines to suppress the immune system
  • Tetracosactide

This information does not contain all possible interactions. Therefore, before using indapamide, tell your doctor or pharmacist of all the products you use.

INDAPAMIDE OVERDOSE

If you take more indapamide that you should, you will experience more side effects. Symptoms of an overdose may include nausea (feeling sick), vomiting (being sick), feeling dizzy and light-headed due to low blood pressure, cramps, drowsiness, confusion, excessive production of urine or low production of urine. If this happens, you should contact your doctor immediately for advice.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of indapamide or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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