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Terms Of Use

IRBESARTAN

Brand Name(s) : Aprovel, CoAprovel
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

IRBESARTAN WARNINGS

Irbesartan should be used with caution in:

  • People with decreased kidney function
  • People who have recently had a kidney transplant
  • People with narrowing of the renal arteries (renal artery stenosis)
  • People on haemodialysis
  • People who get excessive diarrhoea and vomiting
  • People with damaged hearts which have a low filling pressure
  • People with some heart conditions (e.g. heart failure, heart valve disease and hypertrophic obstructive cardiomyopathy)
  • People with low water and salt balances in the body (e.g. due to medicines, low sodiumdiet, vomiting and diarrhoea)
  • Elderly, over 75 years of age
  • People with overproduction of the hormone aldosterone (aldosteronism)
  • People taking lithium or medication containing lithium
  • People taking water tablets (diuretics) and other medicines that lower blood pressure
  • People taking potassium supplements and other medicines that may increase blood potassium levels
  • People taking some types of painkiller, known as non-steroidal anti-inflammatory drugs

It should not be used in:

  • People allergic to irbesartan or any of its ingredients
  • Women who are more than 3 months pregnant (It is also better to avoid irbesartan in early pregnancy)
  • Children (under 18 years)
  • People with rare hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption

Also see list of precautions and interactions

STORAGE

Do not store above 30°C.

IRBESARTAN USES

Irbesartan (Aprovel) is used as an antihypertensive drug.

It is an angiotensin-II receptor antagonist, sometimes known as an angiotensin receptor blocker (ARB).

It is used to treat people with high blood pressure (hypertension). Angiotensin II is a substance produced in the body, which binds to receptors inside the blood vessels causing them to tighten and narrow. This increases the pressure within the blood vessels. Irbesartan acts by preventing the binding of the hormone angiotensin II to its receptors. This widens and relaxes the blood vessels as well as reducing the activity of aldosterone in the kidney. The reduction of aldosterone activity results in less salt and water retention in the kidneys and less fluid in the blood.

In general this drug is used to decrease high blood pressure and prevent kidney damage in people who have high blood pressure and type 2 diabetes mellitus. It can also be used in combination with the water tablet (diuretic), hydrochlorothiazide (Co-Aprovel).

Benefits of being on this drug include the lowering of blood pressure with the effects maintained during long-term treatment. In patients who also have type 2 diabetes and kidney disease, it helps protect the kidney and reduces the risk of developing further kidney problems (end-stage renal disease).

Listed below are the typical uses of irbesartan.

  • Treatment of high blood pressure.
  • Treatment of kidney problems (renal disease) in people with type 2 diabetes mellitus and high blood pressure.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally usually once daily, with or without food.
  • Use this medication for duration of prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to 4 to 6 weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Irbesartan is unlikely to affect your ability to drive or use machines. However, during treatment dizziness or weariness may sometimes occur. If you are affected you should avoid driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop. Always complete the full course as prescribed by your doctor.

IRBESARTAN SIDE EFFECTS

  • High blood potassium levels, particularly in people with high blood pressure and diabetics with kidney disease
  • Increases in an enzyme known as creatine kinase
  • Dizziness
  • Dizziness from sitting up or standing
  • Low blood pressure from sitting up or standing
  • Nausea and vomiting
  • Pain in muscles and/or bones
  • Fall in haemoglobin level in the blood
  • Tiredness
  • Diarrhoea
  • Indigestion
  • Increased heart rate
  • Flushing
  • Chest pain
  • Cough
  • Problems with sexual performance
  • Decreased kidney function
  • Headache
  • Ringing in the ears
  • Bad taste in the mouth
  • Muscle pain
  • Joint pain
  • Allergic reaction (e.g. rash, swelling, hives)
  • Liver problems
  • Inflammation of blood vessels

If any of these persist or you consider them severe then inform doctor or pharmacist.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

IRBESARTAN PRECAUTIONS

Before taking irbesartan, tell your doctor or pharmacist if you are allergic to it; or to other angiotensin-II receptor antagonists; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Rare hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • kidney problems
  • heart disease
  • hydration or salt balance problems
  • Overproduction of the hormone aldosterone (aldosteronism)

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect irbesartan.

The elderly: irbesartan should be used with caution in the elderly aged over 75 years of age due to declining kidney function; therefore dosage adjustment may be necessary.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Irbesartan is not safe to take if you are, or are planning to become, pregnant. It is not recommended in early pregnancy, and may cause serious harm to your baby if it is used after the first 3 months of pregnancy (second and third trimesters).

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Irbesartan is not safe to take if you are breastfeeding

It is not known whether Irbesartan passes into breast milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

IRBESARTAN INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

If you are currently using any of these medications, tell your doctor or pharmacist before starting Irbesartan.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Water tablets (diuretics) and other medicines that lower blood pressure
  • Some types of painkiller, known as non-steroidal anti-inflammatory drugs

This information does not contain all possible interactions. Therefore, before using irbesartan, tell your doctor or pharmacist of all the products you use.

IRBESARTAN OVERDOSE

If overdose is suspected, the most likely manifestations are expected to be low blood pressure, increased heart rate and slow heart rate.

The patient should be monitored closely. Suggested treatments include induction of emesis and/or gastric lavage. Activated charcoal may be useful in overdose treatment.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of irbesartan or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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