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ISOSORBIDE MONONITRATE

Brand Name(s) : None
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

ISOSORBIDE MONONITRATE WARNINGS

Isosorbide mononitrate should be used with caution in:

It should not be used in:

  • People who had a heart attack; acute circulatory failure (a condition in which your blood has stopped flowing round your body properly); very low blood pressure; patients with anaemia (reduction in red blood cells which can make the skin pale and cause weakness or breathlessness); people with low blood volume (hypovolaemia); people taking sildenafil (“Viagra”) or any other phosphodiesterase inhibitor; shock or vascular collapse; glaucoma; patients with the following heart conditions - hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, cardiac tamponade, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with raising intra-cranial (head) pressure e.g. following a head trauma and including cerebral haemorrhage;.

Also see list of precautions and interactions.

STORAGE

No special storage conditions are required.

ISOSORBIDE MONONITRATE USES

Isosorbide mononitrate is used to widen the blood vessels in your heart, therefore allowing more blood to flow to where it is needed.

It is an organic nitrate, sometimes known as an anti-anginal drug.

It is used to prevent angina pectoris and treat congestive heart failure.

In general this drug is used to prevent angina pectoris and as additional therapy in patients with congestive heart failure who have not responded to treatment with cardiac glycosides or diuretics.

Benefits of being on this drug can include prevention of angina and treatment of congestive heart failure.

Listed below are the typical uses of isosorbide mononitrate.

  • Prevention of angina; congestive heart failure.

HOW TO USE/TAKE

How often do I take it?

  • Always take isosorbide mononitrate exactly as your doctor has instructed. You will need to have a period of time (usually during the night) when you don't take any of the medication. This is known as a 'nitrate low' and is necessary for the medication to be effective.
  • Take this medication orally two to three times per day, as instructed by your doctor, with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor .

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

ISOSORBIDE MONONITRATE SIDE EFFECTS

  • Throbbing headache
  • Hypotension (low blood pressure) and/or light headedness
  • Dizziness
  • Drowsiness
  • Weakness
  • Increased heart rate

If any of these persist or you consider them severe then inform our doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

ISOSORBIDE MONONITRATE PRECAUTIONS

Before taking isosorbide mononitrate, tell your doctor or pharmacist if you are allergic to it; or to other nitrates; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • previous heart attack (myocardial infarction); acute circulatory failure (a condition in which your blood has stopped flowing round your body properly); very low blood pressure; patients with the following heart conditions - hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, cardiac tamponade, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with raising intra-cranial (head) pressure e.g. following a head trauma and including cerebral haemorrhage; patients with anaemia (reduction in red blood cells which can make the skin pale and cause weakness or breathlessness); low blood volume (hypovolaemia); very low blood pressure; shock or vascular collapse; glaucoma.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: recent history of heart disease; an underactive thyroid gland; liver or kidney disease; hypothermia; poor circulation; malnutrition; intolerance to certain sugars.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Do not drink alcohol whilst taking isosorbide mononitrate; it can increase its effect and lower your blood pressure too much.

The elderly: isosorbide can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of isosorbide mononitrate use in pregnancy has not been established.

Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether isosorbide mononitrate passes into breast milk. The manufacturer therefore states that you should consult your doctor before taking isosorbide mononitrate before breastfeeding.

Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

ISOSORBIDE MONONITRATE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • phosphodiesterase type-5 inhibitors e.g. sildenafil, tadalafil and vardenafil.
  • If you are currently using any of these medications, tell your doctor or pharmacist before starting isosorbide mononitrate.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • beta-blockers,
  • calcium channel blockers,
  • vasodilators,
  • alprostadil,
  • aldesleukin,
  • angiotensin II receptor antagonists
  • ergotamine

This information does not contain all possible interactions. Therefore, before using isosorbide mononitrate, tell your doctor or pharmacist of all the products you use.

ISOSORBIDE MONONITRATE OVERDOSE

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of isosorbide mononitrate or intentional overdose is suspected, immediately contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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