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Terms Of Use

IVABRADINE

Brand Name(s) : Procoralan
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

IVABRADINE WARNINGS

Ivabradine should be used with caution in: the elderly, patients with symptoms of tiredness or shortness of breath, chronic retinal (eye) disease, chronic heart failure, moderate liver disease, severe renal disease, mild to moderate low blood pressure.

It should not be used in:

  • children and adolescents aged less than 18 years, patients who are allergic to ivabradine or to any other ingredients in the medicine, patients who have a slow heart rate when resting, cardiogenic shock (a heart condition treated in hospital), recent stroke, heart rhythm problems, heart attack, very low blood pressure, unstable angina (a severe type of angina that occurs often and with or without exertion), heart failure which has recently become worse, severe liver problems, patients with a pacemaker, intolerance to some sugars, pregnancy, breastfeeding.

Also see list of precautions and interactions

STORAGE

No special storage conditions are required.

IVABRADINE USES

What is it used for?

  • Ivabradine is used to reduce the heart rate by a few beats per minute in patients with the heart condition angina. Angina happens when the heart does not receive enough oxygen and is more likely to occur when the heart beats faster during for example exercise or after eating. This causes chest pain and discomfort. By reducing the heart rate, ivabradine reduces the heart's need for oxygen particularly in situations when an angina attack is more likely to occur.
  • Ivabradine is also used in the treatment of mild to severe chronic heart failure.
  • It is a channel blocker sometimes known as a heart rate lowering drug.
  • Ivabradine is used to treat the heart condition stable angina pectoris which causes chest pain. It is used if beta blocker medicines such as atenolol, metoprolol and propranolol are not suitable for you or in combination with beta blockers in patients whose condition is not fully controlled with beta blockers.
  • Ivabradine is also used in the treatment of chronic heart failure in combination with standard therapy or when beta blockers are not suitable.
  • In general this drug is used to treat the heart conditions of stable angina pectoris and chronic heart failure.

Listed below are the typical uses of ivabradine.

  • The heart condition stable angina pectoris
  • Treatment of mild to severe chronic heart failure

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How do I take it?

  • Take this medication by mouth usually twice a day, with food.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some days before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Ivabradine may cause changes in your eyesight including brief moments of increased brightness most often caused by sudden changes in light intensity. If you experience these symptoms you should be careful when driving or using machines at times when there could be sudden changes in light intensity, especially when driving at night. Limit the amount of grapefruit juice that you drink while taking ivabradine. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

IVABRADINE SIDE EFFECTS

  • Eyesight problems which include blurred vision and having brief moments of increased brightness, most often caused by sudden changes in light intensity
  • Slowing down of your heart rate
  • Headache
  • Dizziness
  • Awareness of your heart beat (palpitations)
  • Changes in heart rhythm
  • Feeling sick
  • Constipation
  • Diarrhoea
  • Feeling giddy (vertigo)
  • Shortness of breath
  • Muscle cramps
  • Increased blood levels of creatinine
  • Increased blood levels of uric acid
  • High white blood cell count (eosinophilia)
If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Slowing of your heart rate at rest and/or dizziness, tiredness and low blood pressure.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

IVABRADINE PRECAUTIONS

Before taking ivabradine, tell your doctor or pharmacist if you are allergic to it; or to other heart rate lowering medicines; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: an allergy to ivabradine or to any other ingredients in the medicine, a slow heart rate when resting, cardiogenic shock (a heart condition treated in hospital), recent stroke, heart rhythm problems, heart attack, very low blood pressure, unstable angina (a severe type of angina that occurs often and with or without exertion), severe liver problems, a pacemaker, intolerance to some sugars, are pregnant or breastfeeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: symptoms of tiredness or shortness of breath, chronic retinal (eye) disease, chronic heart failure, moderate liver disease, severe renal disease, mild to moderate low blood pressure.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect ivabradine.

The elderly: ivabradine should be used with caution in the elderly aged 75 years or more. A lower starting dose should be used in elderly patients aged 75 years or more.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Ivabradine is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Ivabradine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

IVABRADINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

If you are currently using any of these medications, tell your doctor or pharmacist before starting ivabradine.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • diltiazem
  • verapamil
  • fluconazole
  • rifampicin
  • barbiturates
  • grapefruit juice
  • phenytoin
  • St John's wort
  • quinidine
  • disopyramide
  • ibutilide
  • sotalol
  • amiodarone
  • bepridil
  • pimozide
  • ziprasidone
  • sertindole
  • mefloquine
  • halofantrine
  • pentamidine
  • cisapride

This information does not contain all possible interactions. Therefore, before using ivabradine, tell your doctor or pharmacist of all the products you use.

IVABRADINE OVERDOSE

Taking too much ivabradine, may cause the following: breathlessness, feeling tired.

People who have taken too much ivabradine should contact their doctor immediately.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of ivabradine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take the next dose at the usual time. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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