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Terms Of Use

KETOROLAC TROMETAMOL

Brand Name(s) : Acular, Toradol
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

KETOROLAC TROMETAMOL WARNINGS

Ketorolac eye drops should be used with caution in:

  • People who are at greater risk of bleeding
  • People taking drugs that may stop blood clotting
  • People with a history of stomach ulcers
  • People also taking corticosteroid eye drops or ointment
  • Wearers of soft contact lenses
  • Eye infections

Ketorolac injection and tablets should be used with caution in:

  • Elderly
  • Women attempting to conceive
  • People taking other drugs that could increase the risk of stomach ulcers or bleeding, such as corticosteroid tablets (for a range of conditions, including joint pain, inflammation and allergic reactions), selective serotonin-reuptake inhibitors (for depression)
  • People with a history of stomach disease, such as ulcerative colitis, Crohn's disease
  • Kidney problems
  • Liver problems
  • Heart problems that affect the blood circulation (cardiac decompensation)
  • Heart disease
  • People with a history of allergies
  • People who are very unwell
  • High blood pressure (hypertension)
  • A disease called systemic lupus erythematosus (SLE), in which the immune system attacks the body causing damage and inflammation

Ketorolac eye drops should not be used in:

  • Allergy (hypersensitivity) to ketorolac, any other ingredient, aspirin or other NSAIDs
  • Children
  • Pregnancy
  • Breast-feeding

Ketorolac injection and tablets should not be used in:

  • Allergy (hypersensitivity) to ketorolac, any of the other ingredients or other NSAIDs
  • People who have or ever had stomach problems such as ulcer or bleeding
  • Severe heart failure
  • Severe kidney problems
  • Severe liver problems
  • Disorders of the blood, such as problems with clotting in haemophilia
  • People with bleeding in the brain
  • People allergic (hypersensitive) to other pain killers, such as aspirin and ibuprofen
  • People with lumps in their nose (nasal polyps)
  • People taking oxpentifylline (for the blood circulation), probenecid (for gout) or lithium (for mental health problems such as depression)
  • People scheduled for an operation
  • Pregnancy, labour and delivery
  • Breast-feeding
  • Children under 16 years of age
  • People at high risk of bleeding after an operation or who are still bleeding from an operation
  • A condition that causes swelling of the skin or mucus membranes in the nose, lips, ears, sexual organs (genitals) and bottom (anus) called angioedema
  • Breathing problems, such as asthma and a narrowing of the airways (bronchospasm)
  • People taking other NSAIDs
  • People with a low volume of blood (hypovolaemia) due to dehydration or blood loss
  • People taking drugs that thin the blood, such as warfarin and low-dose heparin
  • People taking aspirin
  • People before or during surgery

Also see list of precautions and interactions

STORAGE

Store ketorolac tablets in their original packaging to protect from moisture and light.

Ketorolac eye drops do not need any special storage conditions.

KETOROLAC TROMETAMOL USES

What is it used for?

  • Ketorolac tablets and injection are used to treat pain straight after an operation. Ketorolac eye drops are used to prevent and reduce inflammation (swelling, redness and heat) and pain of the eye after eye surgery.
  • It is a type of non-steroidal anti-inflammatory drug (NSAID).
  • It is used to block the action of prostaglandins, which are produced by the pain in response to injury and disease and cause swelling, pain and inflammation.
  • In general this drug is used for pain relief and to prevent and reduce inflammation after an operation.
  • Benefits of being on this drug can include relief of pain and inflammation after an operation.

Listed below are the typical uses of ketorolac:

  • Prevention and reduction of pain and inflammation of the eye after eye surgery (eye drops)
  • Management of moderate to severe pain for a short period of time after an operation (injection and tablets)

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take ketorolac exactly as your doctor has told you. The injection can be used for a maximum of 2 days and the tablets for no longer than 7 days
  • This medicine is usually started in hospital
  • Use this medication for the duration of the prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Ketorolac eye drops may cause temporary blurred vision. If this happens, do not drive or operate machinery. Ketorolac injection and tablets may cause dizziness, drowsiness, tiredness, problems with sight, headaches and problems sleeping. If these symptoms occur, do not drive or operate machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.

KETOROLAC TROMETAMOL SIDE EFFECTS

Ketorolac eye drops:

  • Mild stinging and/or burning
  • Temporary blurred vision
  • Irritation, such as redness, itchiness, puffiness, mild pain and watery eyes
  • Headache
  • Allergic (hypersensitive) reaction
  • Ulcers of the surface of the eye

Ketorolac injection and tablets:

If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • If sick, blood or bits that look like coffee grounds in the vomit
  • Black sticky stools, bleeding from the back passage (anus) or bloody diarrhoea
  • Upset stomach with stomach pain, fever, feeling or being sick, which indicates stomach ulcers
  • Severe stomach pain that spreads to the back
  • Worsening of ulcerative colitis or Crohn's disease, such as pain, diarrhoea, being sick and weight loss
  • Sudden swelling of the throat, face, hands or feet
  • Difficulty breathing
  • Tightness in the chest
  • Skin rashes, blisters or itching
  • A severe rash that develops quickly, which may be accompanied by fever, headache, cough and muscle aches
  • Chest pain spreading to the neck and shoulders and down the left arm, which indicates a heart attack
  • Signs of a stroke, including muscle weakness and numbness and a sudden change in the sense of smell, taste, hearing or sight, and confusion
  • Signs of meningitis, including fever, feeling or being sick, a stiff neck, headache, sensitivity to light and confusion
  • Signs of liver problems, such as yellowing of the skin and whites of the eyes, feeling tired, loss of appetite, feeling or being sick and pale coloured stools
  • Difficulty in passing urine

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

KETOROLAC TROMETAMOL PRECAUTIONS

Before taking ketorolac, tell your doctor or pharmacist if you are allergic to it; or to other NSAIDs; or if you have any other allergies.

Ketorolac eye drops should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Allergy (hypersensitivity) to ketorolac, any other ingredient, aspirin or other NSAIDs
  • Pregnancy
  • Breastfeeding

Ketorolac injection and tablets should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Allergy (hypersensitivity) to ketorolac, any of the other ingredients or other NSAIDs
  • Current or history of stomach ulcer of bleeding
  • Severe heart failure
  • Severe kidney problems
  • Severe liver problems
  • Disorders of the blood, such as problems with clotting in haemophilia
  • Bleeding in the brain
  • Allergic (hypersensitive) to other pain killers, such as aspirin and ibuprofen
  • Lumps in the nose (nasal polyps)
  • Pregnancy, labour and delivery
  • Breastfeeding
  • At high risk of bleeding after an operation or who are still bleeding from an operation
  • A condition that causes swelling of the skin or mucus membranes in the nose, lips, ears, sexual organs (genitals) and bottom (anus) called angioedema
  • Breathing problems, such as asthma and a narrowing of the airways (bronchospasm)
  • A low volume of blood (hypovolaemia) due to dehydration or blood loss

Before using ketorolac eye drops, tell your doctor or pharmacist your medical history, especially any of the following:

  • At risk of bleeding
  • Taking drugs that may stop blood clotting
  • A history of stomach ulcers
  • Also taking corticosteroid eye drops or ointment
  • Eye infections

Before using ketorolac injection and tablets, tell your doctor or pharmacist your medical history, especially any of the following:

  • Trying to get pregnant
  • Taking other drugs that could increase the risk of stomach ulcers or bleeding, such as corticosteroid tablets (for a range of conditions, including joint pain, inflammation and allergic reactions), selective serotonin-reuptake inhibitors (for depression)
  • A history of stomach disease, such as ulcerative colitis, Crohn's disease
  • Kidney problems
  • Liver problems
  • Heart problems that affect the blood circulation (cardiac decompensation)
  • Heart disease
  • A history of allergies
  • High blood pressure (hypertension)
  • A disease called systemic lupus erythematosus (SLE), in which the immune system attacks the body causing damage and inflammation

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect this drug.

The elderly: ketorolac should be used with caution in the elderly as they have an increased risk of side effects, especially stomach bleeding and stomach problems which may be fatal.

People with stomach problems. Ketorolac should be used with caution in people with stomach problems as it increases the risk of stomach ulcers and bleeding.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Ketorolac is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Ketorolac is not safe to take if you are breastfeeding

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

KETOROLAC TROMETAMOL INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Ketorolac eye drops should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None known

Ketorolac injection and tablets should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Other NSAIDs
  • Aspirin
  • Drugs that thin the blood, such as warfarin and heparins
  • A drug called lithium that is used for depression
  • A drug for gout called probenecid

If you are currently using such medications, tell your doctor or pharmacist before starting ketorolac.

Before using ketorolac eye drops, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Corticosteroids used to treat skin problems (psoriasis) as a cream or ointment

Before using ketorolac injection and tablets, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • A diuretic (water tablet) used for high blood pressure (hypertension) called furosemide
  • A drug called ciclosporin that is used for various conditions, such as after organ transplant, the skin condition psoriasis and rheumatoid arthritis
  • Drugs used for high blood pressure (hypertension) called beta-blockers and ACE inhibitors, such as cilazapril, enalapril and propanolol
  • Cardiac glycosides for heart problems, such as digoxin
  • Corticosteroids that are used to treat a range of conditions, including skin diseases and joint pain or inflammation, such as prednisolone, hydrocortisone and dexamethasone
  • Quinolone antibiotics for bacterial infections, such as ciprofloxacin and moxifloxacin
  • Drugs for mental health problems, such as fluxetine and citalopram
  • Methotrexate used for cancer and autoimmune diseases
  • A drug used for skin problems (psoriasis) or after an organ transplant called tacrolimus
  • A drug used to treat HIV infection and AIDS called zidovudine
  • A drug used to end a pregnancy or to bring on labour called mifepristone

This information does not contain all possible interactions. Therefore, before using ketorolac, tell your doctor or pharmacist of all the products you use.

KETOROLAC TROMETAMOL OVERDOSE

The effects of overdose with ketorolac eye drops are not known.

Taking too much ketorolac injection and tablets, may cause the following: headache, nausea, being sick, stomach pain, diarrhoea, drowsiness, feeling excited, confusion, ringing in the ears, fainting and convulsions.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of ketorolac or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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