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LATANOPROST

Brand Name(s) : Xalatan
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

LATANOPROST WARNINGS

Latanoprost should be used with caution in: patients who are about to have or have had eye surgery (including cataract surgery), patients with eye problems that include eye pain, irritation or inflammation, blurred vision or dry eyes, other types of glaucoma other than open-angle glaucoma, aphakia (absence or loss of the natural eye lens), pseudoaphakia (implantation of an artificial lens), patients with risk factors for cystoid macular oedema (build up of fluid in the retina with cyst formation), patients at risk of iritis/uveitis (inflammation of the iris or uvea of the eye), those with severe or poorly controlled asthma, patients who wear contact lenses.

It should not be used in: patients who are allergic to latanoprost or to any other ingredients contained in the medicine

Also see list of precautions and interactions

STORAGE

Store unopened latanoprost eyedrops in a refrigerator between 2 and 8ºC and protect from light.
After opening the medicine it is not necessary to store the bottle in a refrigerator. Store at or below 25ºC, protect from light and use within 4 weeks of opening.

LATANOPROST USES

Latanoprost is used to reduce eye pressure (intraocular pressure) in patients with ocular hypertention or open-angle glaucoma.

It is a prostaglandin analogue.

It is used to increase the natural outflow of fluid (aqueous humour) from inside the eye into the bloodstream.

In general this drug is used to treat the eye conditions open-angle glaucoma and ocular hypertension which are caused by an increase in pressure within the eye. These conditions can eventually affect eyesight.

Benefits of being on this drug can include a reduction in pressure within the eye

Listed below are the typical uses of latanoprost:

  • open-angle glaucoma
  • ocular hypertension.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • One drop should be applied to the affected eye(s) once a day, preferably in the evening. Immediately after applying latanoprost eye drops to the eye, press a finger against the corner of the affected eye by the nose and hold for 1 minute while keeping the eye closed. It is important that you do not use latanoprost eye drops more than once a day. Make sure you wait at least 5 minutes before using latanoprost and any other eye drops. If you wear contact lenses, you should remove them before using latanoprost eye drops. After using latanoprost eye drops you should wait at least 15 minutes before putting your lenses back in. Make sure you closely follow the instructions provided with your medicine telling you exactly how to apply your eye drops.
  • Use latanoprost regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to 8 to 12 hours before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Latanoprost may make your eyesight blurred for a short length of time. If this happens do not drive or operate machine or use any tools until your eye sight becomes clear again. Latanoprost eye drops contain a preservative called benzalkonium chloride which can be absorbed onto the surface of contact lenses and may discolour soft contact lenses. If you wear soft contact lenses it is important that you do not allow them to come into contact with latanoprost eye drops. If you wear contact lenses, you should remove them before using latanoprost eye drops. After using the eye drops you should wait 15 minutes before putting your lenses back in. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

LATANOPROST SIDE EFFECTS

  • A gradual change in eye colour which appears as an increase in the brown pigment in the coloured part of the eye (iris). This can occur within 8 months or may take several years, may be permanent and is usually more noticeable if latanoprost is only used in one eye
  • Redness of the eye
  • Eye irritation (you may feel burning, grittiness, itching or stinging in your eye or feel as though you have a foreign body in your eye)
  • A darkening and increase in length, thickness and number of the eye lashes or development of misdirected eyelashes around your treated eye (this is most common in Japanese people)
  • Irritation or disruption to the surface of the eye
  • Inflammation of the eyelid (blepharitis)
  • Eye pain
  • Swelling of the eyelid (oedema)
  • Dryness of he eye
  • Inflammation or irritation of the surface of the eye (keratitis)
  • Blurred eye sight
  • Inflammation of the outer most layer of the eye and inner surface of the eyelids (conjunctivitis)
  • Skin rash
  • Inflammation of the iris (iritis/uveitis, the coloured part of the eye)
  • Swelling of the retina (macular oedema) or around the eye (periorbital oedema)
  • Darkening of the skin of the eyelids
  • Asthma or worsening of asthma
  • Shortness of breath (dyspnoea)
If any of these persist or you consider them severe then inform your doctor or pharmacist.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website

LATANOPROST PRECAUTIONS

Before taking latanoprost tell your doctor or pharmacist if you are allergic to it or to other prostaglandin analogues; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an allergy to latanoprost or to any other ingredients contained in the medicine, are aged under 18 years, are pregnant or breastfeeding or trying to become pregnant.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: you are about to have or have had eye surgery (including cataract surgery), eye problems that include eye pain, irritation or inflammation, blurred vision or dry eyes, other types of glaucoma other than open-angle glaucoma, aphakia (absence or loss of the natural eye lens), pseudoaphakia (implantation of an artificial lens), risk factors for cystoid macular oedema (build up of fluid in the retina with cyst formation), you are at risk of iritis/uveitis (inflammation of the iris or uvea of the eye), severe or poorly controlled asthma, you wear contact lenses.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect latanoprost.

The elderly: latanoprost can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Latanoprost is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Latanoprost is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

LATANOPROST INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • There are no medicines known to have absolute contraindications in patients taking latanoprost

If you are currently using any of these medications, tell your doctor or pharmacist before starting latanoprost

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other eye drops that contain prostaglandins, prostaglandin derivatives or prostaglandin analogues such as bimatoprost or travoprost

This information does not contain all possible interactions. Therefore, before using latanoprost tell your doctor or pharmacist of all the products you use.

LATANOPROST OVERDOSE

If you put too many latanoprost eye drops in your eye you may develop a minor eye irritation and your eye may become red and watery. These symptoms should disappear but if you are worried then contact your doctor.

Contact your doctor immediately if you accidentally swallow latanoprost eye drops.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of latanoprost or intentional overdose is suspected, contact your local hospital, GP or if in England call 111 or NHS Direct. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, carry on with your usual dosage at the usual time. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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