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Terms Of Use

LOFEPRAMINE

Brand Name(s) : Feprapax
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

LOFEPRAMINE WARNINGS

Lofepramine should be used with caution in: women who are pregnant or likely to become pregnant or who are breastfeeding, the elderly, those who have heart problems or an abnormal blood pressure, those with kidney or liver problems, previous or current mental diseases such as mania or psychoses, or who have an overactive thyroid, epilepsy, brain damage, long-term constipation, a tumour (cancer) of the adrenal gland (such as phaeochromocytoma or neuroblastoma), increased pressure in the eye (known as narrow-angle glaucoma), patients having difficulty in passing urine, who are undergoing electroconvulsive therapy (ECT) or anaesthesia, or those who wear contact lenses.

It should not be used in: children under 18 years of age, patients with heart problems such as a recent heart attack (myocardial infarction) or an irregular heart beat (known as arrhythmias, and particularly in the type called heart block), those with severe liver problems, severe kidney problems, those with a blood disorder called acute porphyria, those who are taking a drug called a monoamine oxidase inhibitor (MAOI) within 14 days, and during the manic phase in patients – such as those with bipolar disorder (sometimes called manic depression) – who experience this mental symptom.

Also see list of precautions and interactions.

STORAGE

Store below 25°C.

LOFEPRAMINE USES

What is it used for?

Listed below are the typical uses of lofepramine.

  • Treatment of depressive states.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth, usually twice or three-times daily.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • As this medication may make you feel drowsy you may need to avoid driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

LOFEPRAMINE SIDE EFFECTS

If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: feeling more depressed and/or thinking about suicide; effects on the blood (as may be indicated by fever or chills, sore throat, ulcers in the throat or mouth, unusually severe tiredness or weakness, unusual bleeding or bruising); jaundice (indicated by yellowing of the eyes and/or the skin).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

LOFEPRAMINE PRECAUTIONS

Before taking lofepramine, tell your doctor or pharmacist if you are allergic to it; or to other antidepressants; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: heart problems such as a recent heart attack (myocardial infarction) or an irregular heart beat (known as arrhythmias, and particularly in the type called heart block), severe liver problems, severe kidney problems, taking a drug called a monoamine oxidase inhibitor (MAOI) within 14 days, and during the manic phase in patients – such as those with bipolar disorder (sometimes called manic depression) – who experience this mental symptom.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any episodes of mania (overactive behaviour or thoughts), history of heart problems (particularly heartbeat rhythm problems called arrhythmias), any history of thyroid disease, epilepsy, blood disorders, head injuries or brain damage, long-term constipation, problems urinating, or increased pressure in the eyes (glaucoma).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Avoid alcohol when taking this drug.

The elderly: lofepramine should be used with caution in the elderly as it may cause more, or worse, side-effects than in younger patients.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Lofepramine is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Lofepramine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

LOFEPRAMINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Other antidepressants (monoamine oxidase inhibitors [MAOIs], including the reversible MAOI, moclobemibe)
  • Anti-arrhythmics (amiodarone)
  • Antibiotics (moxifloxacin)
  • Antimalarial agents (artemether/lumefantrine)
  • Antipsychotics (pimozide)
  • Saquinavir used to treat HIV

If you are currently using any of these medications, tell your doctor or pharmacist before starting lofepramine.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Antidepressants (e.g. selective serotonin reuptake inhibitors [SSRIs] such as fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram and escitalopram; other tricarboxylic acid [TCA] antidepressants such as amitriptyline; duloxetine; lithium; and the herbal medicine St John's wort
  • Anti-arrhythmics (e.g. disopyramide, flecainide, procainamide, propafenone or sotalol)
  • Antibiotics (e.g. rifampicin)
  • Anti-epileptics such as carbamazepine, phenytoin or primidone, including barbiturates (e.g. phenobarbital)
  • Antifungals (e.g. terbinafine)
  • Anti-psychotics (e.g. clozapine and phenothiazine derivatives)
  • Antihistamines (such as those found in cough and cold remedies)
  • Antihypertensives (e.g. clonidine)
  • Antiviral agents (e.g. ritonavir)
  • Blood-thinning drugs (e.g. warfarin)
  • Diuretics (e.g. bendroflumethiazide, indapamide or furosemide)
  • Parkinson's disease medicines (e.g. rasagiline or selegiline)
  • Strong pain killers (e.g. tramodol or morphine)
  • Others: atomoxetine, used to treat attention deficit hyperactivity disorder (ADHD), pentamidine isetionate (used to treat infections by protazoan micro-organisms), adrenaline and noradrenaline.

This information does not contain all possible interactions. Therefore, before using lofepramine, tell your doctor or pharmacist of all the products you use.

LOFEPRAMINE OVERDOSE

Symptoms of an overdose are not reported, but it may be less dangerous in overdose than other tricyclic antidepressants.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of lofepramine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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