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Terms Of Use

LOSARTAN

Brand Name(s) : Cozaar
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

LOSARTAN WARNINGS

Losartan should be used with caution:

  • if you have a history of angioedema (swelling of the face, lips, throat, and/or tongue)
  • if you suffer from excessive vomiting or diarrhoea
  • if you receive diuretics (medicines that increase the amount of water that you pass out through your kidneys) or are on a low saltdiet
  • if you have narrowing or blockage of the blood vessels leading to your kidneys or if you have received a kidney transplant recently
  • if your liver function is impaired
  • if you suffer from heart failure with or without renal impairment or severe life threatening cardiac arrhythmias, or if you are being treated with a beta-blocker
  • if you have problems with your heart valves or heart muscle
  • if you suffer from heart disease (caused by a reduced blood flow in the blood vessels of the heart) or from cerebrovascular disease (caused by a reduced blood circulation in the brain)
  • if you suffer from primary hyperaldosteronism, a syndrome that can lead to low levels of potassium in the blood

It should not be used in:

Also see list of precautions and interactions

STORAGE

Tablets: store in the original container, please see Patient Information Leaflet for details

Cozaar suspension: store the prepared suspension in the fridge between 2 and 8°C

LOSARTAN USES

What is it used for?

  • Losartan is used to lower blood pressure.
  • It is an angiotensin-II receptor antagonist, sometimes known as an angiotensin receptor blocker (ARB).

  • It is used if you have high blood pressure (hypertension).
  • In general this drug is used if you have high blood pressure, if you have kidney disease with high blood pressure and type 2 diabetes (also known as late onset diabetes), have chronic heart failure where treatment with specific type of medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors) is considered not suitable, or if you have high blood pressure and are at a higher risk of having a stroke because your heart muscle is thickened/enlarged (left ventricular hypertrophy).
  • Benefits of being on this drug can include lowering blood pressure, lowering pressure within the kidneys thereby reducing the risk of damage to the kidneys, improving the symptoms of heart failure, and reducing the risk of stroke.

Listed below are the typical uses of losartan.

  • Treatment of high blood pressure in adults and in children and adolescents aged 6-18 years.
  • Treatment of kidney disease in patients with high blood pressure and type 2 diabetes mellitus.
  • Treatment of chronic heart failure, when treatment with another medication known as an ACE inhibitors is not considered suitable. If you have heart failure and have been treated effectively with an ACE inhibitor you should not be switched to losartan.
  • Reducing the risk of stroke in patients with high blood pressure and thickening of the left ventricle shown on an electrocardiogram (by ECG).

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • If you have high blood pressure that does not respond to losartan alone you may be treated with losartan and hydrochlorothiazide as a combination medication (known as Cozaar-Comp). Losartan may be taken with other blood pressure lowering medicines.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally usually once daily with water, with or without food.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to 3-6 weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • You may feel drowsy or dizzy when you first start taking an antihypertensive medication or if you have just increased your dose. You should bear this in mind if driving or operating machinery. If you are taking diuretics (medicines that increase the amount of water that you pass out through your kidneys) or are under dietary salt restriction you should tell you doctor before taking losartan. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

LOSARTAN SIDE EFFECTS

Stop taking losartan and tell your doctor immediately if you develop any of the following symptoms:

  • swelling of the face, lips, throat, and/ or tongue

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

LOSARTAN PRECAUTIONS

Before taking losartan, tell your doctor or pharmacist if you are allergic to it; or to other angiotensin receptor blockers; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an allergy (hypersensitivity) to losartan or severe liver disease, if you are pregnant or if you are planning to become pregnant, or if you are breastfeeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: have a history of angioedema (swelling of the face, lips, throat, and/or tongue), you suffer from excessive vomiting or diarrhoea, you receive diuretics (medicines that increase the amount of water that you pass out through your kidneys) or are on a low saltdiet, have narrowing or blockage of the blood vessels leading to your kidneys or if you have received a kidney transplant recently, your liver function is impaired, you suffer from heart failure with or without renal impairment or severe life threatening cardiac arrhythmias, or if you are being treated with a beta-blocker, you have problems with your heart valves or heart muscle, you suffer from heart disease (caused by a reduced blood flow in the blood vessels of the heart) or from cerebrovascular disease (caused by a reduced blood circulation in the brain), you suffer from primary hyperaldosteronism (a syndrome that can lead to low levels of potassium in the blood).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • There is no recommendation to avoid alcohol. Nevertheless, alcohol may lower blood pressure so you should consider this when taking losartan.

The elderly: losartan may be started at a lower dose in elderly patients.

Losartan may be less effective in lowering blood pressure in black people than in non-blacks, possibly because of higher prevalence of low-renin states in the black patients with high blood pressure.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Losartan is not safe to take if you are, or are planning to become, pregnant.

First trimester: not recommended
Second trimester: avoid
Third trimester: avoid

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Losartan is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

LOSARTAN INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

There are medicines that are known to interact with losartan and your doctor may well have considered this, however if you are taking any of the following medicines please make sure your doctor or pharmacist is aware of this. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other antihypertensive agents
  • Other substances inducing low blood pressure like tricyclic antidepressants, antipsychotics, baclofen, amifostine:
  • Medicines that cause you to retain potassium or may increase potassium levels (e.g. potassium supplements, potassium-containing salt substitutes or potassium-sparing medicines such as certain diuretics [amiloride, triamteren, spironolactone] or heparin)
  • Lithium
  • NSAIDs (non-steroidal anti-inflammatory drugs)

This information does not contain all possible interactions. Therefore, before using losartan, tell your doctor or pharmacist of all the products you use.

LOSARTAN OVERDOSE

Symptoms of overdose are low blood pressure, increased heartbeat, possibly decreased heartbeat

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of losartan or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, resume your usual dosing schedule as soon as possible. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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