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MEBEVERINE HYDROCHLORIDE

Brand Name(s) : Colofac, Colofac MR, Colofac IBS, Fybogel Mebeverine (in combination with ispaghula husk)
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

MEBEVERINE HYDROCHLORIDE WARNINGS

Mebeverine should be used with caution in: children, people with liver or kidney problems and those with a blood disease called porphyria.

It should not be used in: patients with paralytic ileus (lack of bowel movements, leading to blockage of the gut).

Also see list of precautions and interactions.

STORAGE

Store below 30°C.

MEBEVERINE HYDROCHLORIDE USES

What is it used for?

  • Mebeverine is used to treat a number of problems.
  • It is a direct relaxant of gut (intestinal) muscle, and is sometimes known as an antispasmodic drug.
  • It is used to relax the muscles of the intestine and to treat symptoms of irritable bowel syndrome and related conditions.
  • In general this drug is used to manage the symptoms of irritable bowel syndrome, a common intestinal condition which causes spasm and pain in the intestine, as well as stomach pain, persistent diarrhoea (sometimes alternating with periods of constipation) and wind (flatulence).
  • Benefits of being on this drug include reducing the painful and troublesome symptoms of irritable bowel syndrome.

Listed below are the typical uses of mebeverine.

  • Relief from the symptoms of irritable bowel syndrome as well as other conditions usually included in this grouping, such as chronic irritable colon, spastic constipation, mucouscolitis and spastic colitis.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally usually two- or three-times daily, about 20–30 minutes before meals. Tablets or capsules should be taken whole with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • No. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

MEBEVERINE HYDROCHLORIDE SIDE EFFECTS

If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: none listed.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

MEBEVERINE HYDROCHLORIDE PRECAUTIONS

Before taking mebeverine, tell your doctor or pharmacist if you are allergic to it; or to other antispasmodic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: paralytic ileus (lack of bowel movements, leading to blockage of the gut).

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any bleeding disorders (especially bleeding from the gut), severe constipation, having difficulty or pain when passing urine (water), recently had a fever, bloody stools, or have had abnormal vaginal bleeding or discharge, if you have developed any new symptoms or you your symptoms have become worse

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect mebeverine.

The elderly: mebeverine should be used with caution in the elderly as it may cause more side-effects than in younger patients.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Mebeverine safety has not been established in pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Mebeverine safety has not been established in breastfeeding. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

MEBEVERINE HYDROCHLORIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • none known

This information does not contain all possible interactions. Therefore, before using mebeverine, tell your doctor or pharmacist of all the products you use.

MEBEVERINE HYDROCHLORIDE OVERDOSE

There are no reports of overdoses with this drug.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of mebeverine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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