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MEDROXYPROGESTERONE ACETATE

Brand Name(s) : Provera, Depo-Provera
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

MEDROXYPROGESTERONE ACETATE WARNINGS

Medroxyprogesterone acetate should be used with caution in: adolescents aged 12-18 years, epilepsy (fitting), fluid retention (swelling), migraine headaches, asthma, heart problems, disease of the blood vessels, sudden eyesight problems, increased levels of fat in the blood (hyperlipidaemia), systemic lupus erythematosus (SLE), a large increase in blood pressure, kidney problems, diabetes, family history of diabetes, depression or a history of depression, patients with an intolerance to certain sugars.

It should not be used in: patients who are allergic to medroxyprogesterone acetate or to any other ingredients in the medicine or are allergic to other progestogens, patients who have or have had in the past vaginal bleeding (not a period) for which their doctor could not find a cause, patients who have not started their periods, patients who have had a heart attack, patients who have or have had a blood clot in the lungs or veins in the past, patients at risk of developing blood clots, inflammation of the blood vessels (thrombophlebitis), patients who have had a miscarriage or abortion, liver problems, the heart condition angina, increased calcium levels in the blood (hypercalcaemia), the hereditary blood disorder (porphyria), suspected or recently diagnosed breast cancer for the first time, pregnancy, breastfeeding.

Also see list of precautions and interactions

STORAGE

Store in a cool dry place

MEDROXYPROGESTERONE ACETATE USES

What is it used for?

  • Medroxyprogesterone acetate is used to stop the growth of the lining of the uterus (womb) and causes the uterus to produce certain hormones. It can prevent pregnancy and inhibit the growth of certain cancers.
  • It is similar to the natural female sex hormone progesterone, and is sometimes known as a progestogen.
  • In general this drug is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding, to slow down the growth of certain tumours which are sensitive to hormones, to decrease the risk of endometrial hyperplasia (overgrowth of the lining of the womb), a condition that may lead to uterine cancer, and as a contraceptive to prevent pregnancy.
  • Benefits of being on this drug can include decreased bleeding from the vagina or uterus, normal or regular menstrual periods and slowing of tumour growth.

Listed below are the typical uses of medroxyprogesterone acetate.

  • Heavy menstrual periods
  • Painful menstrual periods
  • Irregular menstrual periods or periods that are more frequent than normal
  • Absence of menstrual periods
  • Mild to moderate endometriosis which occurs when tissue from your womb is found outside your womb
  • Cancer of the lining of the womb (endometrial cancer)
  • Cancer that has spread to other parts of the body (metastatic cancer) in women who have stopped having their periods (post-menopausal)
  • Long term prevention of pregnancy (contraception)
  • Occasional contraception (once or twice) in women whose partner is undergoing a vasectomy, women who are being immunised against rubella, women who are awaiting sterilisation.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • Cancer of the breast
  • Cancer of the kidney

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally usually daily in single or divided doses, with or without food. Swallow the tablets whole with water. Depending on your medical condition you may not need to take medroxyprogesterone acetate every day. Make sure you know exactly when to take your medicine. If you are unsure consult your doctor or pharmacist. Other formulations may need to be taken more or less frequently as indicated by your doctor or pharmacist.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Medroxyprogesterone acetate is not known to affect ability to drive or operate machinery. You can drive and operate machinery as long as you feel well and able to do so. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

MEDROXYPROGESTERONE ACETATE SIDE EFFECTS

  • Breast pain or tenderness
  • Milky discharge from breast when not pregnant or breastfeeding (galactorrhoea)
  • Headache
  • Abdominal pain or discomfort
  • Diarrhoea
  • Constipation
  • Depression
  • Feeling dizzy
  • Tiredness
  • Difficulty sleeping
  • Feeling nervous
  • Worsening of diabetes
  • Change in sex drive
  • Backache
  • Leg cramps
  • Blood clots
  • Unexpected or unusual vaginal bleeding or spotting
  • Menstrual periods stop or you have a longer break between periods
  • Skin problems (itching, rash, nettle rash, acne)
  • Excessive hair growth on the face and body
  • Swelling of the hands, ankles, face
  • Increase in weight
  • Hot flushes
  • Problems with eyesight
  • Yellowing of the skin and whites of the eyes
  • Bone thinning
  • Breast cancer
  • If any of these persist or you consider them severe then inform your doctor or pharmacist immediately. Further information about other side effects can be found in the patient information leaflet.

Tell your doctor immediately and stop taking your medicine if you develop any of the following symptoms:

  • Wheezing, difficulty breathing, feeling faint, swelling of the face or tongue, hands and feet, intense itchy skin rash (this may be a sign of an allergic reaction)
  • Unusual vaginal bleeding, loss of eyesight or sudden occurrence of an enlarged eyeball, double vision or migraine headache
  • Sudden severe sharp pain in your chest, coughing up blood, suddenly becoming short of breath and a rapid heart beat (this may be a sign of a blood clot in the lungs)
  • Very bad headache, problems with your eyesight, difficulty speaking, you collapse or faint, or part of your body feels weak or numb (this may be a sign of a stroke)
  • Severe pain, tenderness or swelling in your calf (lower leg), ankle or foot, the skin on your leg becomes purple in colour or becomes red and warm to touch (this may be a sign of deep vein thrombosis or DVT)
  • Yellowing of the skin and whites of the eyes (jaundice)
  • Big increase in blood pressure

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website

MEDROXYPROGESTERONE ACETATE PRECAUTIONS

Before taking medroxyprogesterone acetate, tell your doctor or pharmacist if you are allergic to it; or to other progestogens; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an allergy to medroxyprogesterone acetate or to any other ingredients in the medicine or are allergic to other progestogens, have or have had in the past vaginal bleeding (not a period) for which your doctor could not find a cause, have not started your periods, have had a heart attack, have or have had a blood clot in the lungs or veins in the past, are at risk of developing blood clots, inflammation of the blood vessels (thrombophlebitis), have had a miscarriage or abortion, liver problems, the heart condition angina, increased calcium levels in the blood (hypercalcaemia), the hereditary blood disorder (porphyria), suspected or recently diagnosed breast cancer for the first time, pregnancy, breastfeeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following epilepsy (fitting), fluid retention (swelling), migraine headaches, asthma, heart problems, disease of the blood vessels, sudden eyesight problems, increased levels of fat in the blood (hyperlipidaemia), systemic lupus erythematosus (SLE), a large increase in blood pressure, kidney problems, diabetes, family history of diabetes, depression or a history of depression, have an intolerance to certain sugars.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect medroxyprogesterone acetate.

The elderly: medroxyprogesterone acetate can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Medroxyprogesterone acetate is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Medroxyprogesterone acetate is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

MEDROXYPROGESTERONE ACETATE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Drugs with absolute contraindications to medroxyprogesterone acetate are not listed.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • aminoglutethimide
  • phenobarbital
  • phenytoin
  • carbamazepine
  • primidone
  • rifampicin
  • rifabutin
  • aprepitant
  • bosentan
  • efavirenz
  • nevirapine
  • ritonavir
  • nelfinavir
  • griseofulvin
  • fosamprenavir
  • lamotrigine
  • oxcarbazepine
  • rufinamide
  • selegiline
  • sitaxentan
  • sugammadex
  • tacrolimus
  • terbinafine
  • tizanidine
  • topiramate
  • medicines for cancer
  • medicines for diabetes
  • medicines for thinning the blood such as warfarin
  • thyroid hormones
  • ciclosporin
  • high doses of steroids
  • St John's wort
  • aspirin
  • ibuprofen
  • naproxen
  • hydralazine
  • minoxidil

This information does not contain all possible interactions. Therefore, before using medroxyprogesterone acetate, tell your doctor or pharmacist of all the products you use.

MEDROXYPROGESTERONE ACETATE OVERDOSE

If you take too many tablets contact your doctor straight away.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of medroxyprogesterone acetate or intentional overdose is suspected, contact your local hospital, GP or if in England call 111 or NHS Direct. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take your next dose at the usual time. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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