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Terms Of Use

NICORANDIL

Brand Name(s) : Ikorel
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

NICORANDIL WARNINGS

Nicorandil should be used with caution in:

  • People with low blood volume or low systolic blood pressure
  • People who have recently had a heart attack with heart failure and low filling pressures
  • People with a build up of fluid in the lungs (pulmonary oedema)
  • People with mouth ulcers
  • People using drugs for lowering blood pressure (antihypertensive drugs)

It should not be used in:

  • People with low blood pressure
  • People with cardiogenic shock
  • People with a heart problem, where the heart is damaged and cannot pump enough blood around the body
  • People using drugs for erectile dysfunction (impotence), such as sildenafil, tadalafil and vardenafil
  • People who are allergic to nicorandil or any of its ingredients.

Also see list of precautions and interactions

STORAGE

Do not store above 25°C. Keep the blister strip in the outer carton in order to protect from moisture.

NICORANDIL USES

Nicorandil is used to prevent and treat chronic angina pectoris.

It is a type of drug called a potassium channel activator with a nitrate component.

It is used to maintain blood flow to the heart and prevent angina pain.

In general this drug is used to increase blood flow through the blood vessels of the heart which prevents angina pectoris.

Benefits of being on this drug can include prevention and/or reduction of complications that may arise from having angina pectoris. Studies have shown that the drug can reduce the risk of having a heart attack (myocardial infarction) and other complications such as coronary artery bypass graft for people with angina pectoris.

Listed below are the typical uses of nicorandil.

  • Prevention and treatment of angina pectoris.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

Take this medication orally usually twice daily, with or without food.

Use this medication regularly in order to get the most benefit from it.

Remember to use it at the same time each day - unless specifically told otherwise by your doctor.

Nicorandil has a rapid onset of action.

Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication may cause drowsiness or dizziness. If you are affected you should not drive or operate machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

NICORANDIL SIDE EFFECTS

If any of these persist or you consider them severe then inform doctor or pharmacist as soon as possible.

Tell your doctor or go to hospital immediately if you develop any of the following symptoms:

  • Blood in stools or vomit
  • Yellowing eyes and skin

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

NICORANDIL PRECAUTIONS

Before taking nicorandil, tell your doctor or pharmacist if you are allergic to it; or to other potassium channel activators; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Low blood pressure
  • Cardiogenic shock
  • A damaged heart which has a low filling pressure
  • Heart failure
  • Erectile dysfunction (impotence) and are taking medicines for it such as sildenafil, tadalafil and vardenafil

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Cardiac problems

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • It is advised not to consume alcohol while on the medication.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of nicorandil has not been established during pregnancy. Therefore nicorandil is not safe to take if you are, or are planning to become, pregnant. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether nicorandil passes into breast milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

NICORANDIL INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Medication for impotence which are phosphodiesterase 5 inhibitors (e.g. sildenafil, tadalafil, vardenafil).

If you are currently using any of these medications, tell your doctor or pharmacist before starting nicorandil.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Medication for high blood pressure (antihypertensive drugs)
  • Medication to widen blood vessels (vasodilators)
  • Medication for depression
  • Medication for inflammation (corticosteroids)

This information does not contain all possible interactions. Therefore, before using nicorandil, tell your doctor or pharmacist of all the products you use.

NICORANDIL OVERDOSE

If you take more tablets than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you. This is so the doctor knows what you have taken.

The following effects may happen: you may feel dizzy or weak or have difficulty in breathing or wheezing.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of Nicorandil or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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