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OMEPRAZOLE (MEPRADEC)

Brand Name(s) : Mepradec, Losec, Losec MUPS
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

OMEPRAZOLE WARNINGS

Omeprazole should be used with caution in: those with liver disease.

It should not be used in: patients with dyspepsia (indigestion) or a suspected stomach ulcer if there are 'alarm' symptoms of stomach cancer (bleeding in stools, difficulty in swallowing, recurrent vomiting or weight loss) as this means there is a possibility of cancer which needs to be excluded before treatment with omeprazole is started, as omeprazole treatment may temporarily relieve some cancer symptoms and so delay cancer diagnosis.

Also see list of precautions and interactions.

STORAGE

Store below 25°C

OMEPRAZOLE USES

Omeprazole is used to treat a number of problems.

It is a member of a class of drugs called proton pump inhibitors, sometimes known as PPIs.

In general, this drug is used to treat gastro-oesophageal reflux disease (GORD), or gastric or duodenal (upper intestinal) ulcers.

Benefits of being on this drug include the prevention of excess acid production by the stomach which can lead to the relief of GORD symptoms and may allow healing of ulcers or erosions.

Listed below are the typical uses of omeprazole:

  • Treatment of gastro-oesophageal reflux disease (sometimes called GORD, dyspepsia or heartburn) and relief of associated symptoms such as dyspepsia (indigestion, including pain, bloating or nausea), heartburn and epigastric pain (pain in the chest behind the breast bone)
  • Treatment of duodenal (upper intestinal) and gastric (stomach) ulcers and erosions, including ulcers associated with non-steroidal anti-inflammatory (NSAID) drug use
  • Eradication of a bacteria (Helicobacter pylori) which is often found in the gut and is the cause of stomach ulcers in many patients (omeprazole is used in combination with antibiotics for this purpose).
  • Prevention of stomach acid aspiration (inhalation of stomach acid into the airways), which may happen during a surgical operation
  • Controlling symptoms of Zollinger–Ellison syndrome (a disorder in which excess stomach acid is produced).

However on occasion your doctor may prescribe this medicine to treat a condition not on this list.

HOW TO USE/TAKE

How often do I take it?

  • This medication is widely available as tablets or capsules, which should be taken orally, usually as a single dose every day.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before you notice any benefits of this drug.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy and use of certain interacting medicines.

Do I need to avoid anything?

  • No.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

OMEPRAZOLE SIDE EFFECTS

If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: reddening of the skin with blisters or peeling, severe blistersand bleeding in the lips, eyes, mouth, nose and genitals. This could be ‘Stevens–Johnson syndrome’ or ‘toxic epidermal necrolysis’.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

OMEPRAZOLE PRECAUTIONS

Before taking omeprazole, tell your doctor or pharmacist if you are allergic to it; or to proton pump inhibitors (PPIs); or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any of the 'alarm' symptoms for stomach cancer (bleeding in stools, difficulty in swallowing, recurrent vomiting or weight loss) as this means there is a possibility of cancer which needs to be excluded before treatment with omeprazole is started, as omeprazole treatment may temporarily relieve some cancer symptoms and so delay cancer diagnosis.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect this drug

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Omeprazole is suitable to take during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Omeprazole is suitable to take if you are breastfeeding. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

OMEPRAZOLE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: atazanavir, nelfinavir, saquinavir.

  • If you are currently using any of these medications, tell your doctor or pharmacist before starting omeprazole.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Ketoconazole
  • Itraconazole
  • Voriconazole
  • Diazepam
  • Phenytoin
  • Tacrolimus.

This information does not contain all possible interactions. Therefore, before using omeprazole, tell your doctor or pharmacist of all the products you use.

OMEPRAZOLE OVERDOSE

Symptoms of an overdose include: feeling sick (nausea), vomiting, dizziness, stomach pain, diarrhoea, headache, depression and confusion.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of omeprazole or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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