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Terms Of Use


Brand Name(s) : Creon 10000, Creon 25000, Creon 40000, Creon Micro, Nutrizym 10, Nutrizym 22, Pancrease HL, Pancrex, Pancrex V
Side Effects


Pancreatin should be used with caution in: women who are pregnant, likely to get pregnant, or who are breastfeeding.

It should not be used in: patients who are allergic to pork or any pig products

Also see list of precautions and interactions.


Store below 25°C.


What is it used for?

  • Pancreatin is used to help the digestion of food in patients who do not produce enough natural digestive enzymes.
  • It is a pancreatic enzyme supplement sometimes known as enzyme replacement therapy.
  • It is used to allow efficient digestion of food in people who lack the enzymes to digest fat, carbohydrate or proteins by delivering food-digesting enzymes to the gut. The food-digesting enzymes used in pancreatin are usually produced from the pancreas glands of pigs.
  • In general this drug is used for the treatment of patients who do not produce enough of their own digestive enzymes.
  • Benefits of being on this drug can include better digestion, nutrition, and normal growth.

Listed below are the typical uses of pancreatin.

  • Treatment of patients with pancreatin insufficiency (i.e. they do not produce enough digestive enzymes).

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • Take this medication by mouth, with food or just before eating. It is available as capsules, tablets, granules or powder. Normally, capsules or tablets should be swallowed whole and taken with plenty of water. In some cases, powder, granules or the contents of capsules, may be mixed directly with foods (fluids or soft food) before eating or drinking them.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • No. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


  • Diarrhoea
  • Constipation
  • Stomach pain
  • Nausea (feeling sick)
  • Rash
  • Irritation of the mouth
  • Irritation of the anus (back passage)
  • High levels of uric acid in the blood and/or urine
  • Damage to the colon (large intestine).
If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: severe or long-lasting belly pain.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking pancreatin, tell your doctor or pharmacist if you are allergic to it; or to other enzyme-replacement therapies; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an allergy to pork or to any pig products.

Before using this medication, tell your doctor or pharmacist your medical history.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect pancreatin.

The elderly: pancreatin can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below


The safety of pancreatin has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Pancreatin is suitable to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • none known.
  • Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

    • none.

    This information does not contain all possible interactions. Therefore, before using pancreatin, tell your doctor or pharmacist of all the products you use.


    There are no reports of overdoses with this drug.

    If you think you, or someone you care for, might have accidentally taken more than the recommended dose of pancreatin or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


    If you forget to take your medicine, wait until your next meal and take your usual dose then. Do not double your dose.

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    Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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