Boots WebMD Partners in Health
Return To Boots

Medicines & treatments centre

Terms Of Use

PROCYCLIDINE

Brand Name(s) : Arpicolin, Kemadrin
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

PROCYCLIDINE WARNINGS

Procyclidine should be used with caution in:

  • The elderly
  • People with heart problems
  • People with high blood pressure
  • People with kidney or liver problems
  • People with an eye condition due to increased pressure in the eye (narrow angle glaucoma) or risk factors for glaucoma
  • People with conditions which may lead to a blocked intestine such as a paralytic ileus (inactivity of intestine which results in delayed emptying and movement through the gut) or pyloric stenosis (narrowing of part of the stomach)
  • Men with an enlarged prostate gland
  • People with a mental illness
  • People taking anticholinergic medications and certain other medications (see interactions)

It should not be used in:

  • People with a known hypersensitivity (allergy) to procyclidine or any of the other ingredients in the medication
  • People with myasthenia gravis (a condition which leads to muscle weakness)
  • People with an eye condition due to increased pressure in the eye (closed angle glaucoma)
  • People with difficulty urinating (urinary retention)
  • People with a blocked intestine (symptoms of swollen stomach, stomach pain, nausea and vomiting)

Also see list of precautions and interactions

STORAGE

Tablets
Store below 25°C

Syrup
Store at or below 25°C

PROCYCLIDINE USES

What is it used for?

  • Procyclidine is used to treat some of the symptoms of Parkinson's disease and similar symptoms caused as side-effects of certain medications.
  • It is an anticholinergic drug, sometimes known as an antimuscarinic drug.
  • It is used to treat some of the symptoms of Parkinson's disease. This is a disease characterised by stiff muscles, tremor and slow movement. Procyclidine acts by reducing the effects of excess acetylcholine on the brain. Procyclidine is also used to treat Parkinsonism-like symptoms caused by some medications used to treat mental illness (antipsychotics). It is not used to treat tardive dyskinesia (a disorder with abnormal repetitive involuntary movements of the face and tongue).
  • In general this drug is used to treat Parkinson's disease and Parkinsonism-like symptoms caused by certain medications used to treat mental illness (antipsychotics).
  • Benefits of being on this drug can include an improvement in the Parkinsonism symptoms of stiff muscles and tremor, but little effect on slow movement. It also helps relieve symptoms such as sweating, dribbling saliva, abnormal eye movements and depression and helps to improve talking, walking and hand control.

Listed below are the typical uses of procyclidine.

  • Parkinson's disease
  • Drug induced Parkinsonism-like symptoms (but not tardive dyskinesia)

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

Procyclidine is available as an oral syrup, tablets and as an injection.

How often do I take it?

  • Take this medication by mouth usually 3 times daily, with or without food. Swallow the tablets with a glass of water. The dose is increased gradually by your doctor until a suitable dose is found that controls your symptoms.
  • The injection may be administered by a doctor or nurse as an injection into a muscle or into a vein.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take several days before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication may affect your ability to drive or operate machinery or do other skilled tasks as it can cause dizziness, blurred vision, confusion and make you feel disorientated. Avoid doing these tasks until you are sure that you are not affected. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
  • You must not stop taking this medication abruptly. If the medication needs to be stopped your doctor will lower it gradually.

PROCYCLIDINE SIDE EFFECTS

  • Difficulty urinating
  • Dry mouth
  • Blurred vision
  • Constipation
  • Feel sick (nausea)
  • Vomiting
  • Inflammation of the gums
  • Dizziness
  • Confusion
  • Nervous or anxious feeling
  • Feel agitated
  • Feel disorientated
  • Hallucinations
  • Poor memory
  • Problems concentrating
  • Rash
If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Uncontrolled repetitive movements of the face and tongue
  • Abnormal body movements (such as of hands, arms and legs)

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website

PROCYCLIDINE PRECAUTIONS

Before taking procyclidine, tell your doctor or pharmacist if you are allergic to it; or to other anticholinergic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Known hypersensitivity (allergy) to procyclidine or any of the other ingredients in the medication
  • An eye condition due to increased pressure in the eye (closed angle glaucoma)
  • Difficulty urinating (urinary retention)
  • Myasthenia gravis, a condition which leads to muscle weakness
  • A blocked intestine (symptoms of swollen stomach, stomach pain, nausea and vomiting)

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following:

  • Kidney or liver problems
  • High blood pressure
  • Heart problems
  • An eye condition due to increased pressure in the eye (narrow angle glaucoma) or risk factors for glaucoma
  • Any conditions which may lead to a blocked intestine such as a paralytic ileus (inactivity of intestine which results in delayed emptying and movement through the gut) or pyloric stenosis (narrowing of part of the stomach)
  • An enlarged prostate gland
  • Any mental illness

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect procyclidine.

The elderly: procyclidine should be used in caution in the elderly as it may be more likely to cause side effects.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of procyclidine has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether procyclidine passes into breast-milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

PROCYCLIDINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None known

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Amantadine and levodopa used to treat Parkinson’s disease
  • Antihistamines such as astemizole and terfenadine used to treat allergies
  • Domperidone and metoclopramide used to treat nausea and vomiting
  • Disopyramide and quinidine used to treat abnormal heart rhythm
  • Ketoconazole used to treat fungal infections
  • Memantine used to treat Alzheimer’s disease
  • Monoamine oxidase inhibitors (MAOIs) such as isocarboxazid and phenelzine used to treat depression
  • Nefopam used to treat pain
  • Nitrates which dissolve in the mouth to treat angina
  • Phenothiazines such as chlorpromazine or thioridazine used to treat mental illness (psychoses, e.g. schizophrenia)
  • Tricyclic antidepressants such as amitriptyline, and other medications such as clozapine and paroxetine used to treat depression

This information does not contain all possible interactions. Therefore, before using procyclidine, tell your doctor or pharmacist of all the products you use.

PROCYCLIDINE OVERDOSE

Taking too much procyclidine may cause the following:

  • agitation, restlessness, confusion and fast heart beat with severe sleeplessness. The effects can last for up to 4 days.

People who have taken too much procyclidine, should talk to a doctor or go to a hospital straight away. Take the medicine pack with you.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of procyclidine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111 or NHS Direct. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Find a medication

Search by medication name for information on over-the-counter or prescription medications including side effects and interactions.
indicates detailed medicines information

Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

Search for a medicine or treatment

Search by medicine name or treatment for information including side effects and interactions.

Ex. Simvastatin, Ibuprofen, Amitriptyline Hydrochlorine

Popular Slideshows & Tools on Boots WebMD

woman looking at pregnancy test
Early pregnancy symptoms
donut on plate
The truth about sugar addiction
womans toned abdomen
A workout for a toned tummy
79x79_less_is_more_with_exercise.jpg
Which exercises are safe?
hand extinguishing cigarette
13 best tips to stop smoking
Immune-boosting foods
The role of diet
79x79_not_good_for_you.jpg
18 secrets men want you to know
boy looking at broccoli
Quick tips for feeding picky eaters
hamburger and fries
A guide for beginners
salmon dinner
A diet to boost your mood & energy
polka dot dress on hangar
Lose weight without dieting