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Terms Of Use

PROMAZINE

Brand Name(s) : None
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

PROMAZINE WARNINGS

Promazine should be used with caution in:

It should not be used:

  • People who have had a reaction to promazine, other medicines like promazine or any of the ingredients
  • People who have dulled senses such as feeling sleepy or uncoordinated, having blurred vision, slurred speech or being less aware of your surroundings
  • People who are in an unconscious state
  • People with bone marrow depression (reduced immune system response)
  • People with a tumour of the adrenal gland associated with attacks of high blood pressure (phaeochromocytoma)

Also see list of precautions and interactions

STORAGE

Store below 25ºC.

PROMAZINE USES

What is it used for?

  • Promazine is used to control restlessness and agitation.
  • It is a dopamine inhibitor, sometimes known as an antipsychotic drug.
  • It is used to address imbalances of certain chemicals in the brain.
  • In general this drug is used to help control restlessness and agitation and treat agitation and restlessness in the elderly.

Listed below are the typical uses of promazine.

  • Short-term management of moderate to severe agitation
  • Agitation and restlessness in the elderly

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth exactly as directed by your doctor.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • You should not drive or operate machinery if this medicine makes you drowsy, or causes you to have blurred vision.
  • Care should be taken in taking this medicine in very hot weather as your body temperature may be affected.
  • Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

PROMAZINE SIDE EFFECTS

  • drowsiness,
  • sedation,
  • agitation,
  • over-excitement,
  • sleeplessness,
  • confusion,
  • fits,
  • nasal stuffiness,
  • dry mouth,
  • blurred vision and other eye problems (clouding of the lens or purple colouring of the eye),
  • constipation,
  • difficulty in urinating (particularly, if you have an enlarged prostate gland),
  • irregular heart beats,
  • low blood pressure (which may show as dizziness, particularly when standing),
  • heart attack can occur,
  • impaired sexual function,
  • breast development in men,
  • skin rashes,
  • sensitivity to light,
  • jaundice (yellowing of the skin and whites of the eyes),
  • shakiness,
  • restlessness,
  • difficulty in speaking,
  • difficulty in walking,
  • tardive dyskinesia (e.g. twitching or abnormal movements of the tongue, face, mouth, jaw or throat, jerky movements of the body),
  • inability to move eyes,
  • muscle spasms,
  • loss of balance,
  • changes in blood and liver function,
  • a sore throat and fever.
If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Unusually fast heart beats,
  • unstable blood pressure,
  • sweating,
  • very high body temperature,
  • muscle stiffness,
  • change in consciousness leading to coma.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

PROMAZINE PRECAUTIONS

Before taking promazine, tell your doctor or pharmacist if you are allergic to it; or to other similar medicines (antipsychotics); or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have or are:

  • had a reaction to promazine, other medicines like promazine or any of the ingredients
  • bone marrow depression (reduced immune system response)
  • dulled senses such as feeling sleepy or uncoordinated, having blurred vision, slurred speech or being less aware of your surroundings
  • in an unconscious state
  • a tumour of the adrenal gland associated with attacks of high blood pressure .

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • liver disease,
  • jaundice or history of jaundice,
  • blood disorders,
  • heart disorders,
  • respiratory problems,
  • kidney disease,
  • Parkinson's disease,
  • enlarged prostate gland,
  • underactive thyroid gland,
  • narrow angle glaucoma (abnormal pressure in the eye accompanied with pain and blurred vision),
  • epilepsy,
  • chronic muscle weakness and fatigue,
  • hardening of the arteries,
  • suffered from a stroke,
  • low potassium or magnesium in your blood.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • You must not take alcohol whilst taking promazine.

The elderly: promazine can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Promazine is not safe to take if you are, or are planning to become, pregnant. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Promazine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

PROMAZINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Monoamine oxidase inhibitors (antidepressants),
  • medication which affects electrolyte balance such as diuretics (water tablets),
  • high blood pressure medication,
  • anti-Parkinson drugs,
  • anti-depressants (e.g. amitriptyline or maprotiline),
  • painkillers,
  • epilepsy medication,
  • diabetic medication,
  • medicines that dull the senses such as sleeping tablets,
  • medication that inhibits the production of blood cells (i.e. carbamazepine, co-trimoxazole, chloramphenicol, sulphonamides, azapropazone, penicillamine),
  • lithium (used to treat mood disorders),
  • cisapride (used to treat heart burn or reflux disease),
  • medicine used to treat infections (sparfloxacin, moxifloxacin, erythromycin),
  • medicines used to treat mental illness (e.g. pimozide, chlorpromazine, trifluoperazine, sertindole or haloperidol),
  • antihistamines (used to treat allergies, e.g. terfenadine),
  • medicine used to treat malaria (e.g. quinine, mefloquine),
  • diuretics (used to treat heart failure and high blood pressure e.g. furosemide or indapamide),
  • heart medication (e.g. quinidine, disopyramide, procainamide, amiodarone, sotalol, dofetilide).

This information does not contain all possible interactions. Therefore, before using promazine, tell your doctor or pharmacist of all the products you use.

PROMAZINE OVERDOSE

If an overdose is suspected a doctor or hospital should be contacted immediately. The symptoms that may occur are deep sleep, agitation and occasionally excitement leading to coma and fits.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of promazine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, wait until the next dose is due, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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