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Terms Of Use

PROPANTHELINE BROMIDE

Brand Name(s) : Pro-Banthine
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

PROPANTHELINE BROMIDE WARNINGS

Propantheline should be used with caution in: the elderly, children, those with liver or kidney problems, patients with Down's syndrome, high blood pressure (hypertension), elevated thyroid levels (hyperthyroidism), heart failure, severe heart disease, heart attacks, conditions causing rapid heart rates (e.g. cardiac surgery), heartbeat rhythm problems (arrhythmias), those with gastro-oesophageal reflux disease (sometimes called GORD, dyspepsia or heartburn), severe constipation, fever, ulcerative colitis (a disease of the lower intestine [colon] characterised by open sores [ulcers] with symptoms such as frequent diarrhoea mixed with blood), patients with a potential partial intestinal obstruction (particularly following surgery on the gut), autonomic neuropathy (a nervous system condition which affects the bladder muscles, the heart, the digestive tract and the genital organs) or women who are pregnant or breastfeeding.

It should not be used in: patients with paralytic ileus (lack of bowel movements, leading to blockage of the gut), intestinal atony (loss of intestinal muscle strength), severe ulcerative colitis (a disease of the lower intestine [colon] characterised by open sores [ulcers] with symptoms such as frequent diarrhoea mixed with blood), toxic megacolon (a life-threatening complication of other intestinal conditions consisting of an abnormal enlargement of part of the gut called the colon, plus bloating, and sometimes fever, pain or shock), myasthenia gravis (a muscle weakness disease), those with an enlarged prostate (which can cause problems with urination), pyloric stenosis (narrow opening from the stomach to the intestines), hiatus hernia (stomach tissue bulging into the lower gullet) associated with gastro-oesophageal reflux disease (sometimes called GORD, dyspepsia or heartburn), or with increased pressure in the eye (e.g. shallow anterior chamber or narrow angle glaucoma).

Also see list of precautions and interactions.

STORAGE

Store below 25°C.

PROPANTHELINE BROMIDE USES

What is it used for?

  • Propantheline is used to treat a number of problems.
  • It is a direct relaxant of smooth muscle, such as is found in the gut (intestine) and bladder and/or tubes leading to the outside (the genito-urinary tract), and is sometimes known as an antispasmodic, antimuscarinic or anticholinergic drug.
  • It is used to relieve cramps in the stomach, intestine and genito-urinary tract, and other conditions characterised by spasm of the smooth muscles found in these areas.
  • In general this drug is used to treat spasms in the gastrointestinal tract. Other uses include the prevention of involuntary release of urine (in adults) by relaxing the muscles which cause this problem. It is also used to prevent excessive sweating (hyperhidrosis).
  • Benefits of being on this drug include reducing spasms in the gastrointestinal tract, as well as preventing involuntary urine release and excessive sweating.

Listed below are the typical uses of Propantheline.

  • Relief from the symptoms of stomach and intestine disorders which involve muscle spasms
  • Relief from enuresis (wetting; resulting from involuntary release of urine) in adults
  • Preventing excessive sweating (hyperhidrosis).

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth, usually daily, and at least 1 hour before meals. Tablets should be taken whole with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take a while before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • As this medication can cause drowsiness or blurred sight then patients should not drive or operate machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

PROPANTHELINE BROMIDE SIDE EFFECTS

If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: painful red eye with loss of sight.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

PROPANTHELINE BROMIDE PRECAUTIONS

Before taking propantheline, tell your doctor or pharmacist if you are allergic to it; or to other antispasmodic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: paralytic ileus (lack of bowel movements, leading to blockage of the gut), intestinal atony (loss of intestinal muscle strength), severe ulcerative colitis (a disease of the lower intestine [colon] characterised by open sores [ulcers] with symptoms such as frequent diarrhoea mixed with blood), toxic megacolon (a life-threatening complication of other intestinal conditions consisting of an abnormal enlargement of part of the gut called the colon, plus bloating, and sometimes fever, pain or shock), myasthenia gravis (a muscle weakness disease), those with an enlarged prostate (which can cause problems with urination), increased pressure in the eye (e.g. narrow angle glaucoma), hiatus hernia (stomach tissue bulging into the lower gullet) associated with gastro-oesophageal reflux disease (sometimes called GORD, dyspepsia or heartburn), or pyloric stenosis (narrow opening from the stomach to the intestines).

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any previous history of gastro-oesophageal reflux disease (sometimes called dyspepsia or heartburn), having difficulty or pain when passing urine (water), recent fever or bloody stools.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect propantheline.

The elderly: propantheline should be used with caution in the elderly as it may cause more side-effects than in younger patients.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Propantheline is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Propantheline is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

PROPANTHELINE BROMIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: None known.

If you are currently using any of these medications, tell your doctor or pharmacist before starting propantheline.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other antispasmodics (e.g. hyoscine, propantheline or dicycloverine)
  • Antihistamines, such as those used to treat allergies, travel sickness or cough and cold remedies (e.g. promethazine, chlorphenamine, or diphenhydramine)
  • Anti-sickness medicines (e.g. hyoscine hydrobromide, cyclizine, domperidone or metoclopramide)
  • Antidepressants (e.g. tricyclic antidepressants [TCAs] such as amitriptyline or clomipramine, and any monoamine oxidase inhibitors [MAOIs] such as moclobemide)
  • Antiarrhythmics, to control heartbeat rhythm problems (e.g. disopyramide)
  • Antifungals (e.g. ketoconazole)
  • Antipsychotics, used in conditions such as schizophrenia (e.g. haloperidol, chlorpromazine or clozapine)
  • Others: amantadine (used in Parkinson's disease), tiotropium and ipratropium (both used to treat lung conditions such as chronic obstructive pulmonary disease [COPD]).

This information does not contain all possible interactions. Therefore, before using propantheline, tell your doctor or pharmacist of all the products you use.

PROPANTHELINE BROMIDE OVERDOSE

Symptoms of an overdose include: fits, coma (unable to wake), circulatory failure, slowed breathing (respiratory depression), confusion, disorientation, hallucinations and restlessness and inability to move (paralysis).

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of propantheline or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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