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Terms Of Use


Brand Name(s) : Pariet
Side Effects


Rabeprazole should be used with caution in:

It should not be used in:

Also see list of precautions and interactions


Do not store above 25°C. Do not refrigerate.


What is it used for?

  • Rabeprazole is used to heal and prevent gastrointestinal (stomach and guts) problems due to too much stomach acid.
  • It is a proton pump inhibitor (PPI), sometimes known as an ulcer healing drug.
  • Rabeprazole is used to inhibit gastric acid secretion from the stomach and to treat a number of acid related gastrointestinal conditions. It is used to treat intestinal and stomach ulcers and to treat and manage gastro-oesophageal reflux disease (GORD, a condition in which acid rises up from the stomach into the oesophagus [gullet] with symptoms of heartburn, acid regurgitation and pain on swallowing). This can lead to reflux oesophagitis (inflammation of the oesophagus) due to acid repeatedly flowing up from the stomach into the oesophagus. Rabeprazole is used to treat conditions in which too much acid is produced by the stomach such as Zollinger-Ellison syndrome and to prevent intestinal and stomach ulcers in people at risk due to continuous use of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. It can also be given as combination therapy with two antibiotics to get rid of bacteria called Helicobacter pylori from the stomach and intestine to treat ulcers (known as H. pylori triple therapy).
  • In general this drug is used to treat intestinal and stomach ulcers and to treat and prevent GORD / reflux oesophagitis.
  • Benefits of being on this drug can include treatment of stomach and intestinal ulcers and relief from the symptoms of heartburn, acid regurgitation, pain and difficulty swallowing.

Listed below are the typical uses of rabeprazole.

  • Treatment of duodenal (intestinal) ulcer
  • Treatment of gastric (stomach) ulcer
  • Treatment of GORD / reflux oesophagitis
  • Long-term management of GORD / reflux oesophagitis
  • Long-term treatment of Zollinger-Ellison syndrome (tumour producing gastrin which leads to excess acid in the stomach) and other conditions in which too much acid is produced
  • Prevention of gastric and duodenal ulcers in people at risk requiring continuous use of non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (as part of triple therapy)

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


Rabeprazole is available as tablets

How often do I take it?

  • Take this medication by mouth usually one tablet once daily, preferably before breakfast. Swallow the tablets whole with water and do not crush or chew.
  • Use this medication regularly for the duration of your prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take up to six weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Rabeprazole is unlikely to affect your ability to drive or operate machinery. However, if you are affected and feel drowsy, avoid doing these activities until you feel safe to do so. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor. The length of treatment depends upon the condition you are being treated for.


If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately and stop taking the medication if you develop any of the following symptoms:

  • Any signs of a serious allergic reaction (see below)
  • Any unexplained bruising as this may be due to a decrease in your blood platelets

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking rabeprazole, tell your doctor or pharmacist if you are allergic to it; or to other proton pump inhibitors; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Known hypersensitivity to rabeprazole or any of the ingredients in the medication

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following: severe liver problems
unintended weight loss, repeated vomiting, difficulty in swallowing, vomiting blood, blood in your stools and you feel tired and weak (as it is important to rule out cancer)

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect rabeprazole. However, drinking too much alcohol is not advised if you have a gastric or duodenal ulcer.

The elderly: rabeprazole can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below


The safety of rabeprazole has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


It is not known whether Rabeprazole passes into breast-milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Atazanavir (an anti-viral drug used to treat HIV infection)
  • Ulipristal (contraceptive effect of ulipristal may be reduced)

If you are currently using any such medicine, tell your doctor or pharmacist before starting rabeprazole.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

This information does not contain all possible interactions. Therefore, before using rabeprazole, tell your doctor or pharmacist of all the products you use.


The effects of overdose with rabeprazole are not known.

People who have taken too much rabeprazole, should contact a doctor or local hospital. Take the tablets and the carton with you.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of rabeprazole or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

If you forget to take your medicine for more than 5 days, call your doctor before taking any more medicine.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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