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Terms Of Use

ROTIGOTINE

Brand Name(s) : Neupro
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

ROTIGOTINE WARNINGS

Rotigotine should be used with caution in:

  • People with liver problems
  • People taking antipsychotics used to treat mental illness or metoclopramide used to treat nausea and vomiting, and some intestinal problems (should be avoided)
  • People taking medications causing sedation (see interactions)

It should not be used in:

  • Children (under 18 years old)
  • People with known hypersensitivity (allergy) to rotigotine or any of the other ingredients in the medication
  • People with severe liver problems
  • People undergoing a magnetic resonance scan (MRI) or undergoing cardioversion (to correct an abnormal heart rhythm) with the patches on (The patches contain a metal- aluminium and must be removed first)

Also see list of precautions and interactions

STORAGE

Store below 25°C

ROTIGOTINE USES

What is it used for?

  • Rotigotine is used to treat Parkinson's Disease and Restless Legs syndrome.
  • It is a dopamine receptor agonist, sometimes known as a dopaminergic drug.
  • It is used to treat Parkinson's Disease. This is a disease characterised by stiff muscles, tremor and slow movement due to a lack of dopamine in a certain area of the brain. Rotigotine stimulates the dopamine receptors in the brain and this helps alleviate the symptoms of Parkinson's disease. Rotigotine can be used alone or in combination with levodopa to treat Parkinson's disease. It is also used to treat Restless Legs syndrome. People with this condition move their legs frequently especially at night and often have difficulty sleeping accompanied by leg discomfort.
  • In general this drug is used to treat people with Parkinson's disease and Restless Legs syndrome.
  • Benefits of being on this drug can include an improvement in the symptoms of Parkinson's Disease of slow movements, stiff muscles and tremor. It also has beneficial effects in reducing the 'off' period seen with levodopa 'on-off' fluctuations in motor function (ability to move) when used as add-on therapy in people with advanced disease. Rotigotine can relieve the symptoms of restless legs.

Listed below are the typical uses of rotigotine.

  • Parkinson's disease (alone as monotherapy or as add-on therapy with levodopa).
  • Restless legs syndrome (moderate to severe).

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

Rotigotine is available as transdermal (skin) patches which you apply once each day.

How often do I take it?

  • Take this medication by applying the patch to your skin, usually once daily and keeping it on for about 24 hours before replacing it with a fresh patch. Apply the patch to a different area of the skin each day and only use the same area of skin again after 14 days.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take up to a few weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines. The dose of rotigotine will be increased slowly by your doctor until the correct dose to control your symptoms has been reached.

Do I need to avoid anything?

  • This medication can cause drowsiness, sometimes excessive drowsiness or sudden onset of sleep during normal activities. This may affect your ability to drive and operate machinery safely. Avoid doing these tasks until you are sure that you are not affected.
  • Avoid getting sunlight on any area of skin showing signs of a reaction to the patches.

Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
  • You must not stop taking this medication abruptly. Your doctor will lower your dose gradually if you need to stop taking rotigotine.

ROTIGOTINE SIDE EFFECTS

Rotigotine for Parkinson's disease:

  • Feeling sick (nausea)
  • Application skin reactions including itching, irritation, rash, burning, blisters and pain
  • Sleepiness
  • Dizziness
  • Abnormal dreams
  • Confusion
  • Hallucinations
  • Difficulty sleeping
  • Abnormal uncontrollable body movements
  • Low blood pressure, especially on changing position (feeling dizzy or faint)
  • Headache
  • Vomiting
  • Diarrhoea
  • Constipation
  • Indigestion
  • Dry mouth
  • Abnormal blood tests- increases in liver function tests
  • Swelling of ankles, feet and hands (due to fluid retention)
  • Tiredness
  • Weakness
  • Weight loss
  • Falls
  • Allergic skin reaction
  • Increased sweating
  • Extreme sleepiness (and sudden onset of sleep during normal activities)
  • Compulsive behaviour (e.g. excessive gambling, shopping, interest in sex)

Some of the side effects in Parkinson's disease are related to taking rotigotine with levodopa (e.g. abnormal uncontrolled movements).

Rotigotine for restless legs syndrome:

  • Feeling sick (nausea)
  • Application skin reactions including itching, irritation, rash, burning, blisters and pain
  • Tiredness
  • Headache
  • Vomiting
  • Indigestion
  • Allergic reaction
  • Sleepiness
  • Difficulty sleeping
  • Extreme sleepiness (and sudden onset of sleep during normal activities)
  • Abnormal dreams
  • Itching
  • High blood pressure
  • Feeling irritable
  • Low blood pressure, especially on changing position (feeling dizzy or faint)
  • Compulsive behaviour (e.g. excessive gambling, shopping, interest in sex)

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor if you develop any of the following symptoms:

  • Any behavioural changes such as excessive compulsive gambling, shopping, binge eating or interest in sex
  • Any changes in your eyesight
  • Extreme sleepiness and sudden onset of sleep while doing your normal daily activities
  • Hallucinations (seeing or hearing things that are not there)
  • Application skin reactions including itching, irritation, rash and redness, if the reaction is severe, lasts longer than a few days or spreads further then the original patch area

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

ROTIGOTINE PRECAUTIONS

Before taking rotigotine, tell your doctor or pharmacist if you are allergic to it; or to other dopaminergic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Known hypersensitivity (allergy) to rotigotine or any of the other ingredients in the medication
  • Severe liver problems

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following:

  • Liver problems

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake may affect rotigotine. You should discuss whether it is safe for you to drink alcohol with your doctor as it may cause additional sedative side effects.

The elderly: rotigotine can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Rotigotine is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Rotigotine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

ROTIGOTINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None known

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

This information does not contain all possible interactions. Therefore, before using rotigotine, tell your doctor or pharmacist of all the products you use.

ROTIGOTINE OVERDOSE

Taking too much rotigotine may cause the following:

  • feeling and being sick (nausea and vomiting), dizziness, drowsiness, tiredness, fainting or hallucinations.

People who have taken too much rotigotine (and used more patches than they were told to) should remove the extra patches and contact their doctor or hospital for advice immediately.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of rotigotine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you have forgotten to change the patch at your usual time, change it as soon as you remember: remove the old patch and use a new one. If you
have forgotten to stick on a new patch after removing the old one, use a new patch as soon as you remember.
In both cases, on the following day you should use a new patch at the usual time. Do not use a double dose to make up for a forgotten dose.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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