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SOLIFENACIN SUCCINATE

Brand Name(s) : Vesicare
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

SOLIFENACIN SUCCINATE WARNINGS

Solifenacin should be used with caution in: women who are pregnant or breastfeeding, children, patients with moderate liver or severe kidney problems, those with autonomic neuropathy (a disease of the non-voluntary [autonomic] nervous system, which can thus affect the bladder muscles), an enlarged prostate gland (prostatic hyperplasia), hiatus hernia (stomach tissue bulging into the lower gullet) with reflux oesophagitis (regurgitation of stomach contents causing damage to the gullet).

It should not be used in: patients undergoing kidney dialysis (haemodialysis), those with myasthenia gravis (a muscle weakness disease), severe liver problems, significant obstruction or retention of urine flow from the bladder, severe ulcerative colitis (a disease of the lower intestine [colon] characterised by open sores [ulcers] with symptoms such as frequent diarrhoea mixed with blood), toxic megacolon (a life-threatening complication of other intestinal conditions consisting of an abnormal enlargement of part of the gut called the colon, plus bloating, and sometimes fever, pain or shock), obstruction of the gut (intestine), intestinal atony (loss of intestinal muscle strength), or increased pressure in the eye (known as narrow-angle glaucoma).

Also see list of precautions and interactions.

STORAGE

No special storage conditions are required.

SOLIFENACIN SUCCINATE USES

What is it used for?

  • Solifenacin is used to treat a number of bladder problems.
  • It is an antimuscarinic drug (it blocks certain types of nerve receptors called the muscarinic acetylcholine receptors), and is sometimes known as an anticholinergic drug.
  • It is used to treat bladder problems involving muscle spasms of the urinary tract. By relaxing overactive bladder muscles it can prevent many bladder problems associated with excessive or involuntary urination.
  • In general this drug is used to treat bladder problems. These can include problems such as urge incontinence (a strong, sudden desire to urinate, and sometimes followed by a bladder contraction before getting to the toilet, allowing urine to leak out), and excessive urination frequency.
  • Benefits of being on this drug can include prevention of involuntary urination (urinary incontinence) or preventing excessive urination (which may be troublesome, particularly at night).

Listed below are the typical uses of solifenacin.

  • Relief from symptoms of urgency to urinate, excessive urination and/or urge incontinence.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth, usually once daily, with or without food. Tablets should be swallowed whole with a drink of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication may cause blurred vision, drowsiness or fatigue, and if so you should avoid driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

SOLIFENACIN SUCCINATE SIDE EFFECTS

This is not a complete list of possible side effects. If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms:

  • blurred sight.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

SOLIFENACIN SUCCINATE PRECAUTIONS

Before taking solifenacin, tell your doctor or pharmacist if you are allergic to it; or to other antimuscarinic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: myasthenia gravis (a muscle weakness disease), severe liver problems, significant obstruction or retention of urine flow from the bladder, severe ulcerative colitis (a disease of the lower intestine [colon] characterised by open sores [ulcers] with symptoms such as frequent diarrhoea mixed with blood), toxic megacolon (a life-threatening complication of other intestinal conditions consisting of an abnormal enlargement of part of the gut called the colon, plus bloating, and sometimes fever, pain or shock), obstruction of the gut (intestine), intestinal atony (loss of intestinal muscle strength), increased pressure in the eye (known as narrow-angle glaucoma), or are undergoing kidney dialysis (haemodialysis).

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: history of difficulty urinating, long-term constipation, blood in stools, any liver or kidney problems, or heart conditions.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake should be moderated as it may intensify side-effects such as drowsiness brought about by solifenacin.

The elderly: solifenacin should used with caution in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of solifenacin has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Solifenacin is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

SOLIFENACIN SUCCINATE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other anticholinergic drugs
  • Cholinergic receptor agonists (e.g. pilocarpine, used to treat dry eyes or before glaucoma operations)
  • Metoclopramide, used to prevent nausea and vomiting.
  • Itraconazole
  • Ketoconazole
  • Ritonavir

This information does not contain all possible interactions. Therefore, before using solifenacin, tell your doctor or pharmacist of all the products you use.

SOLIFENACIN SUCCINATE OVERDOSE

Symptoms of an overdose include: progression from restlessness and excitement to psychotic behaviour and hallucinations, fits, fast heart beat (tachycardia), breathing difficulties, and mydriasis (excessively dilated pupils of the eye).

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of solifenacin or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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