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SUMATRIPTAN

Brand Name(s) : Imigran, Imigran Radis, Imigran Recovery, Imigran Subject
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

SUMATRIPTAN WARNINGS

Sumatriptan should be used with caution in:

  • People with sensitivity (allergy) to sulphonamides
  • People with a history of epilepsy of fits
  • People with risk factors for heart blood flow problems such as high blood pressure, diabetes, smoking, using nicotine substitution therapy, men over 40 years old, postmenopausal women
  • People with liver problems
  • People with kidney problems
  • People with intolerance to some sugars

It should not be used in:

  • hypersensitivity (allergic) to sumatriptan, any of the other ingredients or to medicines called triptans
  • People with heart problems, such as narrowing of the arteries (ischaemic heart disease) or chest pains (angina)
  • People with previous heart attack
  • Previous stroke
  • Previous mini-stroke (transient ischaemic attack, TIA)
  • Severe or uncontrolled high blood pressure
  • Severe liver disease
  • People with peripheral vascular disease (condition with narrowing of the arteries causing reduced blood flow to the legs)
  • rare types of migraine, known as hemiplegic, basilar or ophthalmoplegic migraine,
  • over 65 years old
  • under 18 years old
  • People taking or within 2 weeks of stopping treatment with monoamine oxidase (MAO) inhibitors used to treat depression such as isocarboxazid, moclobemide, phenelzine or tranylcypromine, or linezolid (an antibiotic)
  • People taking sumatriptan with ergotamine or dihydro-ergotamine to treat a migraine attack or methysergide to prevent migraine
  • People taking medications similar to sumatriptan (other triptans such as naratriptan and zolmitriptan) to treat migraine

Also see list of precautions and interactions

STORAGE

Do not store above 30°C.

SUMATRIPTAN USES

What is it used for?

  • Sumatriptan is used to treat the headache and other symptoms of migraine attacks.
  • It is a selective 5-HT1 receptor agonist, sometimes known as a triptan.
  • Sumatriptan is believed to work on the imbalance of the body’s chemicals which causes blood vessels to temporarily swell. This medicine may reduce the size of swollen blood vessels. This in turn helps to take away the headache and relieve other symptoms of a migraine attack.
  • In general this drug is used to treat migraine attacks with or without aura (the sensation at the beginning of a migraine attack before more definite symptoms set in). .
  • Benefits of being on this drug can include relief from the headache and other symptoms of a migraine attack, such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound.

Listed below are the typical uses of sumatriptan.

  • The acute relief of migraine attacks, with or without aura.
  • The acute treatment of cluster headache.
  • Sumatriptan should only be used where there is a clear diagnosis of migraine or cluster headache.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Sumatriptan should be taken as soon as you feel a migraine is coming on, although you can take it at any time during an attack.
  • Do not use sumatriptan to try to prevent an attack – only use it after your migraine symptoms start.
  • If using the tablets, swallow whole with water (do not chew or crush them).
    If you have problems swallowing tablets, Imigran Radis tablets can be dispersed in a small amount of water before they are taken – although this may have a bitter taste.
    For details on how to use the nasal spray or injection, please refer to the product information leaflet in your package.
  • If your symptoms start to come back you can take a second dose if at least 2 hours have passed since the first dose.
    Do not use the nasal spray more than two times in 24 hours.
    If the first tablet has no effect, do not take a second tablet or any other sumatriptan preparation for the same attack.
    Sumatriptan can still be used for your next attack.
  • Wait at least six hours after taking sumatriptan before taking any medicines containing ergotamine or its derivatives.
  • Use this medication as instructed in order to get the most benefit from it.
  • It may take up to 30 minutes before this medication takes effect and relieves headache.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.
  • What dose?

    • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

    Do I need to avoid anything?

    • Drowsiness may occur as a result of migraine or its treatment with sumatriptan, if affected do not drive or operate machinery. Consult your doctor or pharmacist for more details.

    When can I stop?

    • This medication should only be taken during a migraine attack.

    SUMATRIPTAN SIDE EFFECTS

    • Feeling sick (nausea)
    • Being sick (vomiting)
    • Tiredness
    • Drowsiness
    • Dizziness
    • Feeling weak
    • Hot flushes
    • Temporary increase in blood pressure
    • Shortness of breath
    • Dysgeusia (unpleasant taste in your mouth)
    • Tingling, tickling, itching or burning sensations (paraesthesia)
    • Reduced sense of touch (hypoaesthesia)
    • Flushing
    • Mild, transient irritation or burning sensation in the nose or throat or epistaxis (following use of the nasal spray)
    • Breathing difficulties
    • Sensations of heaviness
    • Myalgia (muscle pain)
    • Pain
    • Sensations of heat or cold
    • Pressure or tightness
    • Injection site stinging/burning, swelling, erythema, bruising and bleeding (following injection)
    • See the information leaflet enclosed with your medication for more details on side effects.
    If any of these persist or you consider them severe then inform your doctor.

    Tell your doctor immediately if you develop any of the following symptoms:
    Check with your doctor immediately if you experience any of the following symptoms:

    • Sudden wheeziness
    • Fluttering or tightness in the chest
    • Swelling of eyelids, face or lips
    • Skin rash such as red spots or hives (skin lumps)
    • Fits, usually in people with a history of epilepsy
    • Visual disturbances (although these may occur due to the migraine attack itself)
    • Raynaud's phenomenon, which is a disease characterized by signs of paleness or a blue tinge to the skin and/or pain of the fingers, toes, ears, nose or jaw in response to cold or stress
    • Inflammation of the colon (part of the intestine), which may present as lower left-sided tummy pain and bloody diarrhoea

    Continued pain, heaviness, pressure or tightness in the chest, throat or other parts of the body, or unusual sensations, including numbness, tingling and warmth or cold. These effects may be intense but generally pass quickly. If these effects continue or become severe (especially the chest pain), get medical help urgently. In a very small number of people these symptoms can be caused by a heart attack.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

    This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

    The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

    SUMATRIPTAN PRECAUTIONS

    Before taking sumatriptan, tell your doctor or pharmacist if you are allergic to it; or to other triptans; or if you have any other allergies.

    This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

    • hypersensitivity (allergic) to sumatriptan, any of the other ingredients or to medicines called triptans or sulphonamides,
    • Heart problems, such as narrowing of the arteries (ischaemic heart disease) or chest pains (angina)
    • Previous heart attack
    • Previous stroke
    • Previous mini-stroke (transient ischaemic attack, TIA)
    • Severe or uncontrolled high blood pressure
    • Severe liver disease
    • Peripheral vascular disease (condition with narrowing of the arteries causing reduced blood flow to the legs)
    • Rare types of migraine, known as hemiplegic, basilar or ophthalmoplegic migraine,
    • Taking or within 2 weeks of stopping treatment with monoamine oxidase (MAO) inhibitors used to treat depression such as isocarboxazid, moclobemide, phenelzine or tranylcypromine, or linezolid (an antibiotic)
    • People taking sumatriptan with ergotamine or dihydro-ergotamine to treat a migraine attack or methysergide to prevent migraine
    • People taking medications similar to sumatriptan (other triptans such as naratriptan and zolmitriptan) to treat migraine

    Before using this medication tell your doctor or pharmacist your medical history, especially any of the following:

    • Sensitivity (allergy) to sulphonamides
    • History of epilepsy of fits
    • Risk factors for heart blood flow problems such as high blood pressure, diabetes, smoking, using nicotine substitution therapy, men over 40 years old, postmenopausal women
    • Liver problems
    • kidney problems
    • Intolerance to some sugars

    Before having surgery, tell your doctor or dentist that you are taking this medication.

    Does alcohol intake affect this drug?

    • Alcohol intake is not known to affect sumatriptan.

    The elderly: sumatriptan should not be used in patients over 65 years of age.

    Pregnancy and breastfeeding - please ensure you read the detailed information below

    PREGNANCY

    The safety of sumatriptan has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

    It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

    If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

    BREAST FEEDING

    Sumatriptan passes into breast milk. Breast feeding should be avoided for 12 hours after using sumatriptan.

    It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

    If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

    SUMATRIPTAN INTERACTIONS

    Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

    This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

    • Ergotamine or derivatives of ergotamine (e.g. methysergide),
    • Other triptans such as zolmitriptan, rizatriptan and naratriptan
    • Other sumatriptan containing products
    • Monoamine Oxidase Inhibitors (MAOI’s) (drugs used to treat mood disorders) either now or within the past 2 weeks.

    If you are currently using any such medicine, tell your doctor or pharmacist before starting sumatriptan.

    Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

    This information does not contain all possible interactions. Therefore, before using sumatriptan, tell your doctor or pharmacist of all the products you use.

    SUMATRIPTAN OVERDOSE

    Taking too much sumatriptan may cause the following:

    • Feeling sick (nausea),
    • being sick (vomiting),
    • tiredness,
    • drowsiness,
    • dizziness,
    • feeling weak,
    • hot flushes,
    • temporary increase in blood pressure,
    • shortness of breath,
    • dysgeusia (unpleasant taste in your mouth),
    • tingling, tickling, itching or burning sensations (paraesthesia),
    • reduced sense of touch (hypoaesthesia),
    • flushing,
    • mild, transient irritation or burning sensation in the nose or throat or epistaxis (following use of the nasal spray),
    • breathing difficulties,
    • sensations of heaviness,
    • myalgia,
    • pain,
    • sensations of heat or cold,
    • pressure or tightness.
    • Other, effects may also be experienced. Please see the enclosed patient information leaflet enclosed with your medication for details of less common side effects.

    If you think you, or someone you care for, might have accidentally taken more than the recommended dose of sumatriptan or intentional overdose is suspected, immediately contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

    MISSED DOSE

    Sumatriptan should only be used during a migraine. Speak to your doctor for more information.

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    Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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