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BALSALAZIDE (COLAZIDE)

Brand Name(s) : Colazide
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

BALSALAZIDE WARNINGS

Balsalazide should be used with caution in: patients with liver or kidney problems, asthma, bleeding disorders, or active stomach ulcer disease.

It should not be used in: patients with severe liver problems or moderate-to-severe kidney problems, women who are pregnant or who are breastfeeding children, or in those who have previously had hypersensitivity to mesalazine, aspirin or any salicylate drug.

Also see list of precautions and interactions.

STORAGE

No special storage conditions are required.

BALSALAZIDE USES

What is it used for?

  • Balsalazide is used to treat a number of problems.
  • It is a member of a class of drugs called aminosalicylates.
  • It is used in the treatment of inflammatory bowel (gut) diseases.
  • In general this drug is used to control the symptoms of a type of inflammatory bowel disease called ulcerative colitis, which is a disease of the lower intestine (colon) characterised by open sores (ulcers) with symptoms such as frequent diarrhoea mixed with blood.
  • Benefits of being on this drug include the prevention of the symptoms of ulcerative colitis and remission (absence of active ulcerative colitis), though active ulcerative colitis is likely to reoccur and so another benefit with ongoing maintenance treatment is to prevent active disease from happening again.

Listed below are the typical uses of balsalazide.

  • Treatment of mild-to-moderate ulcerative colitis
  • Maintaining remission of ulcerative colitis (preventing active ulcerative colitis from reoccurring) when given as maintenance treatment.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally, usually several times every day. Tablets should be swallowed whole, with or after food.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day – unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • No.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

BALSALAZIDE SIDE EFFECTS

  • Diarrhoea
  • Feeling sick (nausea)
  • Vomiting
  • Stomach pain
  • Worsening of symptoms of ulcerative colitis
  • Headache
  • Rash
  • Hair loss
  • Red patches of skin with severe itching (hives).

Only the most common side effects have been listed. If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: unexplained bleeding, bruising, purpura (red spots/rash caused by a local bleeding within the skin), sore throat, fever, or generally feeling unwell as these symptoms may indicate a blood disorder.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

BALSALAZIDE PRECAUTIONS

Before taking balsalazide, tell your doctor or pharmacist if you are allergic to it; or to other aminosalicylate drugs, or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver problems or moderate-to-severe kidney problems, are a women who is pregnant or who is breastfeeding, or if hypersensitive to mesalazine, aspirin or any salicylate drug.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any previous liver or kidney problems, asthma, or any bleeding disorders.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Not known.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Balsalazide is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Balsalazide is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BALSALAZIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None.

If you are currently using any of these medications, tell your doctor or pharmacist before starting balsalazide.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Blood-thinning agents (warfarin)
  • Cytotoxic agents (e.g. azathioprine or mercaptopurine)
  • Digoxin
  • Others: methotrexate (used to treat rheumatoid arthritis, Crohn's disease, psoriasis and cancers).

This information does not contain all possible interactions. Therefore, before using balsalazide, tell your doctor or pharmacist of all the products you use.

BALSALAZIDE OVERDOSE

There are no reports of overdoses with this drug.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of Balsalazide or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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