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Terms Of Use

TOLTERODINE TARTRATE

Brand Name(s) : Detrusitol, Detrusitol XL
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

TOLTERODINE TARTRATE WARNINGS

Tolterodine should be used with caution in:

  • children
  • People with liver or kidney problems
  • People with autonomic neuropathy, which is a disease of the non-voluntary (autonomic) nervous system, which can affect the bladder muscles
  • People with an enlarged prostate gland (prostatic hyperplasia)
  • People with an hiatus hernia (stomach tissue bulging into the lower gullet)
  • People with reflux oesophagitis, a regurgitation of stomach contents causing damage to the gullet
  • People with obstruction of the gut (intestine)
  • People with intestinal atony (loss of intestinal muscle strength)
  • People with a history of QT-interval prolongation (a type of rare heart condition) or risk factors for QT-interval prolongation such as heart disease such as cardiomyopathy (weak heart muscle), myocardial ischaemia (reduced blood flow to the heart), arrhythmia (irregular heartbeat) and heart failure
  • People with a slow heart rate known as bradycardia
  • People with abnormally low blood levels of potassium (hypokalaemia), calcium (hypocalcaemia) or magnesium (hypomagnesaemia).

It should not be used in:

  • Women who are pregnant or who are breast-feeding children
  • People with myasthenia gravis (a muscle weakness disease)
  • People who have a significant obstruction or retention of urine flow from the bladder
  • People with severe ulcerative colitis, a disease of the lower intestine (colon) characterised by open sores (ulcers) with symptoms such as frequent diarrhoea mixed with blood
  • People with toxic megacolon (a life-threatening complication of other intestinal conditions consisting of an abnormal enlargement of part of the gut called the colon, plus bloating, and sometimes fever, pain or shock)
  • People suffering an increased pressure in the eye (known as narrow-angle glaucoma).

Also see list of precautions and interactions.

STORAGE

Store below 30°C.

TOLTERODINE TARTRATE USES

What is it used for?

  • Tolterodine is used to treat a number of bladder problems.
  • It is an antimuscarinic drug (it blocks certain types of nerve receptors).
  • It is used to treat bladder problems involving muscle spasms of the urinary tract. By relaxing overactive bladder muscles it can prevent many bladder problems associated with excessive or involuntary urination.
  • In general this drug is used to treat bladder problems. These can include problems such as urge incontinence (a strong, sudden desire to urinate, and sometimes followed by a bladder contraction before getting to the toilet, allowing urine to leak out), and excessive urination frequency.
  • Benefits of being on this drug can include prevention of involuntary urination (urinary incontinence) or preventing excessive urination (which may be troublesome, particularly at night).

Listed below are the typical uses of tolterodine.

  • Relief from symptoms of urgency to urinate, excessive urination and/or urge incontinence.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • None known.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication by mouth, usually once or twice daily, with or without food. Capsules should be swallowed whole.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication may affect vision and slow reaction times, and if so you should consider avoiding driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

TOLTERODINE TARTRATE SIDE EFFECTS

  • Dryness of the mouth
  • Headache
  • Dizziness
  • Sleepiness
  • Sensation of tingling, pricking, or numbness of the skin (paraesthesia)
  • Dry eyes
  • Blurred sight
  • Vertigo (spinning or swaying sensation when standing still)
  • Palpitations (pounding in the chest)
  • Indigestion
  • Constipation
  • Belly pain
  • Dry skin
  • Wind (flatulence)
  • Vomiting
  • Tiredness
  • Chest pain
  • Swelling of the legs, ankles or feet
  • Increased weight
  • Diarrhoea.
This is not a complete list of possible side effects. If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: blurred sight or palpitations (pounding in the chest)

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website

TOLTERODINE TARTRATE PRECAUTIONS

Before taking tolterodine, tell your doctor or pharmacist if you are allergic to it; or to other antimuscarinic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: myasthenia gravis (a muscle weakness disease), significant obstruction or retention of urine flow from the bladder, severe ulcerative colitis (a disease of the lower intestine or colon characterised by ulcers with symptoms such as frequent diarrhoea mixed with blood), toxic megacolon (a life-threatening complication of other intestinal conditions consisting of an abnormal enlargement of part of the gut called the colon, plus bloating, and sometimes fever, pain or shock), or increased pressure in the eye (known as narrow-angle glaucoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: history of difficulty urinating, long-term constipation, blood in stools, any liver or kidney problems, or heart conditions.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake should be moderated as it may intensify side-effects such as drowsiness brought about by tolterodine.

The elderly: tolterodine can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Tolterodine is not safe to take if you are, or are planning to become, pregnant. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Tolterodine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

TOLTERODINE TARTRATE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Antibiotics (erythromycin or clarithromycin)
  • Antifungals (ketoconazole or itraconazole)
  • Anti-virals (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir).

If you are currently using any of these medications, tell your doctor or pharmacist before starting tolterodine.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Other anticholinergic drugs
  • Anti-arrhythmia drugs (amiodarone, sotalol, quinidine and procainamide)
  • Cholinergic receptor agonists (e.g. pilocarpine, used to treat dry eyes or before glaucoma operations)
  • Metoclopramide, used to prevent nausea and vomiting.

This information does not contain all possible interactions. Therefore, before using tolterodine, tell your doctor or pharmacist of all the products you use.

TOLTERODINE TARTRATE OVERDOSE

Symptoms of an overdose include: over-excitement and psychotic behaviour, difficulties focusing, hallucinations, fits, fast heart beat (tachycardia), breathing difficulties, retention of urine, and mydriasis (excessively dilated pupils of the eye).

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of tolterodine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111 or NHS Direct. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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