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Terms Of Use


Brand Name(s) : Molipaxin
Side Effects


Trazodone should be used with caution in: women who are pregnant or likely to become pregnant or who are breastfeeding, those under 18 years of age, the elderly, those who have heart problems such as a recent heart attack (myocardial infarction), an irregular heart beat (known as arrhythmias, particularly in the type called heart block), those with severe liver problems, kidney problems, previous or current mental diseases such as mania or psychoses, or who have thyroid disease, epilepsy, a blood disorder called acute porphyria, increased pressure in the eye (known as narrow-angle glaucoma), who are undergoing electroconvulsive therapy (ECT) or anaesthesia, or have a history of urinary retention (difficulty urinating).

It should not be used in: patients with severe liver problems, those who are taking a drug called a monoamine oxidase inhibitor (MAOI) within 14 days, and during the manic phase in patients such as those with bipolar disorder (sometimes called manic depression) who experience this mental symptom.

Also see list of precautions and interactions.


Store below 30°C.


What is it used for?

  • Trazodone is used to treat depression and anxiety.
  • It is an antidepressant, sometimes known as a tricyclic-related (TCA-related) antidepressant.
  • It is used to treat depression and anxiety.
  • In general this drug is used to treat depression, with or without anxiety, particularly in patients who are agitated as it also acts as a sedative (it has a calming effect).
  • Benefits of being on this drug can include relief from depression and anxiety, and calming of agitated states.

Listed below are the typical uses of trazodone.

  • Treatment of depression, with or without anxiety
  • Treatment of anxiety
  • Treatment of mixed depression and anxiety.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below. Night-time sedation and for certain behavioural symptoms


How often do I take it?

  • Take this medication orally usually once daily before bedtime or during the day as divided doses after eating. Tablets or capsules should be taken whole with a glass of water. It is also available to take as a liquid.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • As this medication may make you feel sleepy or cause dizziness you may need to avoid driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: feeling more depressed and/or thinking about suicide; effects on the blood (as may be indicated by fever or chills, sore throat, ulcers in the throat or mouth, unusually severe tiredness or weakness, unusual bleeding or bruising); long-lasting and/or painful erections in men (priapism); jaundice (indicated by yellowing of the eyes and/or the skin).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking trazodone, tell your doctor or pharmacist if you are allergic to it, or to other antidepressants, or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver problems, taken a drug called a monoamine oxidase inhibitor (MAOI) within 14 days, or if you have a mental disorder such as bipolar disorder (sometimes called manic depression) as it is important not to take this medication during periods of mania (overactive behaviour or thoughts).

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any episodes of mania (overactive behaviour or thoughts), suicidal thoughts or thoughts of self-harm, history of heart problems (particularly heartbeat rhythm problems called arrhythmias), any history of thyroid disease, epilepsy, a blood disorder called acute porphyria, problems urinating, or increased pressure in the eyes (glaucoma).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Drinking alcohol is not recommended when taking this drug.

The elderly: trazodone should be used with caution in the elderly as they may not tolerate high doses as well as younger patients.

Pregnancy and breastfeeding - please ensure you read the detailed information below


The safety of trazodone has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

First trimester: avoid

Second trimester: not known to be harmful

Third trimester: not known to be harmful.

Babies born to mothers taking trazodone should be monitored for signs of withdrawal.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Small amounts of trazodone are passed into breast milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Other antidepressants (monoamine oxidase inhibitors [MAOIs], including the reversible MAOI, moclobemide)
  • Selegiline (for Parkinson's disease)
  • Antibiotics such as erythromycin
  • Antifungals such as ketoconazole
  • Antimalarial agents (artemether/lumefantrine)

If you are currently using any of these medications, tell your doctor or pharmacist before starting trazodone.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Anti-epileptics such as carbamazepine, phenytoin or primidone, including barbiturates (e.g. phenobarbital).

This information does not contain all possible interactions. Therefore, before using trazodone, tell your doctor or pharmacist of all the products you use.


Symptoms of an overdose include: drowsiness, dizziness, nausea, vomiting, coma (unable to wake), changes in heart beat (which may become fast, slow or irregular), low blood pressure (hypotension), breathing difficulties and fits.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of trazodone or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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