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BENDROFLUMETHIAZIDE

Brand Name(s) : Aprinox, Neo-NaClex, Neo-NaClex-K, Centyl K, Prestim (with timolol)
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

BENDROFLUMETHIAZIDE WARNINGS

Bendroflumethiazide should be used with caution in: those with low blood levels of magnesium, liver or kidney problems, diabetes, systemic lupus erythematosus (an autoimmune disease where the body turns upon itself, causing the tissues to become inflamed and swollen), or porphyria (an inherited disorder affecting the blood).

It should not be used in: people who are allergic to thiazides or any ingredient in the medicine, those with severe kidney or liver problems, high blood levels of calcium or low blood levels of potassium or sodium, those with Addison's disease or those who have gout.

Also see list of precautions and interactions.

STORAGE

Store below 25°C

BENDROFLUMETHIAZIDE USES

Bendroflumethiazide is used to treat a number of problems associated with the retention of fluids in the body.

It is a diuretic, sometimes known as a water tablet.

It is used to increase the production of urine (passing water).

In general this drug is used in patients with high blood pressure and/or heart failure, or other conditions that lead to an accumulation of fluid in the body (diseases of the kidneys, liver or lungs).

Benefits of being on this drug can include reductions in blood pressure and relief from some of the symptoms of heart failure.

Listed below are the typical uses of bendroflumethiazide:

  • The treatment of mild or moderate heart failure
  • Control of high blood pressure (hypertension)
  • Prevention or removal of fluid accumulated beneath the skin (oedema).

However on occasion your doctor may prescribe this medicine to treat a condition not on this list. Such conditions are listed below.

  • Elevated levels of calcium in urine (hypercalciuria).

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally usually daily, in the morning with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Bendroflumethiazide can cause dizziness. Make sure you are not affected before driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

BENDROFLUMETHIAZIDE SIDE EFFECTS

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms: leg cramps, skin rash, sensitivity to light (photosensitivity), or unexplained or unusual bruising.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

BENDROFLUMETHIAZIDE PRECAUTIONS

Before taking bendroflumethiazide, tell your doctor or pharmacist if you are allergic to it; or to other thiazide diuretics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver or kidney problems, high blood levels of calcium or low blood levels of potassium or sodium, have Addison's disease (a condition in which the adrenal glands do not make enough of certain hormones called cortisol and aldosterone, with symptoms such as weakness, dizziness and darkened patches of skin), or gout.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: previous gout, any liver or kidney problems, diabetes, systemic lupus erythematosus (an autoimmune disease where the body attacks itself, causing tissues to become inflamed and swollen), or porphyria (an inherited disorder affecting the blood).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Yes. It can increase the likelihood of dizziness on standing up (postural hypotension).

The elderly: bendroflumethiazide should be used with caution in the elderly as reduced doses may be required.

Pregnancy and breast-feeding - please ensure you read the detailed information below.

PREGNANCY

Bendroflumethiazide is not safe to take if you are, or are planning to become, pregnant. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Bendroflumethiazide is not safe to take if you are breastfeeding. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BENDROFLUMETHIAZIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: pimozide or thioridazine (used to treat psychosis).

If you are currently using any of these medications, tell your doctor or pharmacist before starting bendroflumethiazide.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Digoxin
  • Barbiturates
  • Opioids
  • Oestrogens and combined oral contraceptives
  • Tricyclic antidepressants (TCAs)
  • Monoamine oxidase inhibitors (MAOIs)
  • Reboxetine
  • Baclofen
  • Amphotericin
  • Allopurinol
  • Amphotericin
  • Other drugs for high blood pressure: ACE inhibitors, angiotensin-II antagonists, calcium channel blockers
  • Calcium salts
  • Vitamin D supplements
  • Colestipol
  • Colestyramine
  • Lithium
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Xanthines
  • Beta-agonists
  • Corticosteroids
  • Corticotropins
  • Acetazolamide
  • Carbamazepine
  • Cisplatin
  • Prazosin
  • Toremifene
  • Terfenadine
  • .

This information does not contain all possible interactions. Therefore, before using bendroflumethiazide, tell your doctor or pharmacist of all the products you use.

BENDROFLUMETHIAZIDE OVERDOSE

Symptoms of an overdose include: feeling sick (nausea), vomiting, diarrhoea, excessive urine production, dehydration, low blood pressure, dizziness, weakness, muscle cramps, sensation of tingling, pricking, or numbness of the skin (paraesthesia) and muscle contractions (tetany).

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of bendroflumethiazide or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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