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XYLOMETAZOLINE HYDROCHLORIDE

Brand Name(s) : Otrivine, Sudafed
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

XYLOMETAZOLINE HYDROCHLORIDE WARNINGS

Xylometazoline should be used with caution in:

It should not be used in:

  • Allergy (hypersensitivity) to xylometazoline or any of the other ingredients
  • People who have undergone neurosurgery
  • People who are taking or who have taken drugs for depression called monoamine oxidase inhibitors within the previous 2 weeks
  • People taking other similar decongestants
  • Heart problems
  • Problems with blood circulation
  • High blood pressure (hypertension)
  • Overactive thyroid (hyperthyroidism)
  • People taking beta-blockers, which are used for high blood pressure (hypertension)
  • Inflammation of the skin or nose
  • People who have had their pituitary gland removed by surgery
  • Children under 12 years of age
  • Cancer of the adrenal gland (phaeochromocytoma)
  • A type of eye disease with increased pressure inside the eye called closed-angle glaucoma

Also see list of precautions and interactions

STORAGE

Do not store xylometazoline above 25°C.

XYLOMETAZOLINE HYDROCHLORIDE USES

What is it used for?

  • Xylometazoline is used to help clear the stuffy, blocked up feeling in the nose and sinuses caused by colds and allergies such as hayfever.
  • It is a type of decongestant.
  • It is used to contract the blood vessels in the lining of the nose and sinuses, thereby decreasing blood flow and reducing swelling and the feeling of congestion. It also reduces the production of mucus, drying up a blocked and stuffy nose.
  • In general this drug is used to clear a blocked nose and sinuses associated with colds, influenza and allergies such as hay fever.
  • Benefits of being on this drug can include relief of congestion in the nose and sinuses.

Listed below are the typical uses of xylometazoline:

  • Relief of the symptoms of a blocked nose and sinuses associated with a cold, influenza and allergies.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • None known

HOW TO USE/TAKE

How often do I take it?

  • Use xylometazoline exactly as your doctor or pharmacist has told you.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Xylometazoline will not affect your ability to drive or operate machinery. Do not use for more than seven days. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.

XYLOMETAZOLINE HYDROCHLORIDE SIDE EFFECTS

  • Burning sensation in the nose and throat
  • Irritation of the nose
  • Feeling sick
  • Headache
  • Dryness inside the nose
If any of these persist or you consider them severe then inform your doctor or pharmacist.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

XYLOMETAZOLINE HYDROCHLORIDE PRECAUTIONS

Before taking xylometazoline, tell your doctor or pharmacist if you are allergic to it; or to other decongestants; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Allergy (hypersensitivity) to xylometazoline or any of the other ingredients
  • Previous neurosurgery
  • Taking or have taken drugs for depression called monoamine oxidase inhibitors within the previous 2 weeks
  • Taking other similar decongestants
  • Heart problems
  • Problems with blood circulation
  • High blood pressure (hypertension)
  • Overactive thyroid (hyperthyroidism)
  • Taking beta-blockers, which are used for high blood pressure (hypertension)
  • Inflammation of the skin or nose
  • Surgical removal of the pituitary gland
  • Cancer of the adrenal gland (phaeochromocytoma)
  • A type of eye disease with increased pressure inside the eye called closed-angle glaucoma

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following:

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol does not affect this drug.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of xylometazoline has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether xylometazoline passes into breast-milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

XYLOMETAZOLINE HYDROCHLORIDE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Drugs used for depression called monoamine oxidase inhibitors, such as phenelzine, isocarboxazid, tranylcypromine and moclobemide, taken within the last 14 days

If you are currently using any such medicine, tell your doctor or pharmacist before starting xylometazoline.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Drugs used for high blood pressure (hypertension)
  • Drugs used for heart failure and irregular heart beat
  • Drugs used for migraines called ergotamine and methysergide
  • Drugs for suppressing appetite
  • Stimulants
  • A drug used to induce labour called oxytocin

This information does not contain all possible interactions. Therefore, before using xylometazoline, tell your doctor or pharmacist of all the products you use.

XYLOMETAZOLINE HYDROCHLORIDE OVERDOSE

Swallowing xylometazoline may cause the following: rapid and irregular pulse, high blood pressure, drowsiness and breathing problems.

People who have swallowed xylometazoline, should contact a doctor or their nearest hospital casualty department.

The effects of overdose with xylometazoline nasal spray and drops are not known.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of xylometazoline or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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