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Terms Of Use


Brand Name(s) : Clopixol
Side Effects


Zuclopenthixol dihydrochloride should be used with caution in:

  • People with a previous history of severe side effects with, or allergy to, other neuroleptic medicines,
  • Liver disease
  • People with a heart condition
  • People with a family history of heart problems
  • People with an irregular heart beat
  • People with risk factors for stroke e.g. smoking, high blood pressure
  • People with a severe respiratory disease
  • People with renal failure
  • People with epilepsy
  • People with conditions predisposing to epilepsy e.g. alcohol withdrawal or brain damage
  • People with Parkinson's disease
  • People with narrow angle glaucoma
  • People with an enlarged prostate
  • People with hypothyroidism
  • People with hyperthyroidism
  • People with myasthenia gravis (a condition causing severe muscle weakness)
  • People with phaeochromocytoma (a type of cancer of the adrenal gland)
  • The elderly,
  • People with acute porphyria (a condition affecting haemoglobin in the red blood cells.

It should not be used in:

  • People with hypersensitivity to the active substance or to any of the other ingredients
  • People with circulatory collapse
  • People with a depressed level of consciousness due to any cause (e.g. intoxication with alcohol, barbiturates or opiates)
  • Also see list of precautions and interactions


    Keep the tablets in their original container, protected from light and moisture. Store below 25°C.


What is it used for?

Listed below are the typical uses of zuclopenthixol dihydrochloride:

  • schizophrenia,
  • schizophrenia-related psychoses.


How often do I take it?

  • Take this medication orally, in accordance with your doctor's instruction, with a glass of water, usually twice a day.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to 6 hours before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Zuclopenthixol hydrochloride is a sedative drug.
  • Alertness may be impaired, especially at the start of treatment, or following the consumption of alcohol; patients should be warned of this risk and advised not to drive or operate machinery until their susceptibility is known.
  • Patients should not drive if they have blurred vision.
  • Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


  • Drowsiness,
  • Sedation,
  • dizziness,
  • fainting,
  • fast heart beat,
  • blood disorders,
  • eye disorders,
  • ringing in the ears,
  • stuffy nose,
  • dry mouth,
  • stomach pains,
  • constipation,
  • rash,
  • over production of saliva,
  • irregular heart beats,
  • the need to pass urine more frequently,
  • lack of control of passing urine,
  • breast enlargement,
  • impaired erection/ejaculation in men,
  • irregular periods or breast changes in women,
  • increased libido in women,
  • weight gain or weight loss,
  • restlessness,
  • tremors,
  • rigid feelings in the arms or legs,
  • slowed movements.
If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms:

  • Unusual movements of the mouth and tongue, may be an early sign of a serious condition known as tardive dyskinesia.
  • Muscular rigidity, loss of consciousness and high body temperature, especially if occurring with sweating, pallor, fast heart rate or urinary incontinence, may be signs of a serious condition known as neuroleptic malignant syndrome.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking zuclopenthixol dihydrochloride, tell your doctor or pharmacist if you are allergic to it; or to other neuroleptics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Hypersensitivity to the active substance or to any of the other ingredients,
  • Circulatory collapse,
  • Depressed level of consciousness due to any cause (e.g. intoxication with alcohol, barbiturates or opiates), coma.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • If you drink alcohol you may find it affects you more than usual. Consult your doctor or nurse for advice.

The elderly: zuclopenthixol dihydrochloride should be used with caution in the elderly as they are more prone to developing side effects.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Zuclopenthixol dihydrochloride is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Zuclopenthixol dihydrochloride is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Barbiturates
  • CNS depressants
  • General anaesthetics
  • Anticoagulants
  • Anticholinergics
  • Atropine
  • Metoclopramide
  • Piperazine
  • Antiparkinson drugs
  • Lithium
  • Sibutramine
  • Quinidine
  • Corticosteroids
  • Digoxin
  • Hydralazine
  • Doxazosin
  • Methyldopa
  • Quinidine
  • Amiodarone
  • Sotalol
  • Dofetilide
  • Anti-psychotics such as thioridazine
  • Macrolide antibiotics such as erythromycin
  • Antihistamines
  • Quinolone antibiotics such as moxifloxacin
  • Cisapride
  • Lithium
  • Thiazide diuretics
  • Levodopa or other medicines used to treat Parkinson’s disease

This information does not contain all possible interactions. Therefore, before using zuclopenthixol dihydrochloride, tell your doctor or pharmacist of all the products you use.


If you accidentally take too much zuclopenthixol dihydrochloride you should contact a doctor or hospital immediately. If you go to the doctor/hospital take the zuclopenthixol dihydrochloride bottle with you. The doctor may need to give you supportive treatment (e.g. other medicine) for any symptoms that result from the overdose. These symptoms could include sedation, coma, shock, fainting, tremors, fits or temperature changes.

People who have taken too much zuclopenthixol dihydrochloride should seek medical advice.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of megestrol or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited or TicTac Communications Ltd. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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