Chlortalidone should be used with caution in:
It should not be used in:
- Allergy (hypersensitivity) to chlortalidone, sulfonamides such as sulfamethoxazole or any ingredient in the tablet or other diuretics
- Severe liver problems
- Severe kidney problems
- Failure to produce urine (anuria)
- When parathryoid function is being investigated
- When there are low levels of potassium in the blood that can cause muscle weakness, muscle twitching or abnormal heart beat (hypokalaemia)
- High levels of calcium in the blood that can cause loss of appetite, tiredness or muscle weakness (hypercalcaemia)
- Low levels of sodium in the blood that can cause tiredness, confusion, muscle twitching, fits or coma (hyponatraemia)
- High levels of uric acid in the blood that is causing symptoms, such as gout or kidney stones (hyperuricaemia)
- A problem with your adrenal glands that results in inadequate production of natural steroid hormones (Addison's disease)
- A drug used to treat depression called lithium
- High blood pressure (hypertension) due to pregnancy
Also see list of precautions and interactions
No special storage conditions are required.
What is it used for?
Listed below are the typical uses of chlortalidone:
- High blood pressure (hypertension)
- Heart failure
- Fluid collection in the stomach (ascites) due to cirrhosis of the liver
- Fluid retention due to kidney disease (nephrotic syndrome)
- Diabetes insipidus
HOW TO USE/TAKE
How often do I take it?
- Always take chlortalidone tablets exactly as your doctor has told you. It is best to take the tablets in the morning with food. Swallow the tablets whole with a drink of water.
- Use this medication for the duration of the prescription in order to get the most benefit from it.
- Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
- Certain medical conditions may require different dosage instructions as directed by your doctor.
- Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.
Do I need to avoid anything?
- You should avoid low-salt diets as the drug may reduce the amount of salt in your body. When you start to take chlortalidone, you may feel dizzy. If this happens, do not drive or operate machinery. Consult your doctor or pharmacist for more details.
When can I stop?
- Always complete the full course as prescribed by your doctor.
CHLORTALIDONE SIDE EFFECTS
- Low levels of potassium in the blood that cause muscle weakness, muscle twitching or abnormal heart beat is very common
- High levels of uric acid in the blood (hyperuricaemia) is very common
- An increase in cholesterol levels in the blood is very common
- Low levels of sodium that can cause tiredness, confusion, muscle twitching, fits or coma (hyponatraemia) is common
- High levels of sugar in blood (hyperglycaemia) is common
- Low levels of magnesium (hypomagnesaemia) is common
- Loss of appetite is common
- Dizziness is common
- Impotence is common
- Skin rash is common
- Feeling dizzy when moving from lying down to sitting or standing (postural hypotension) is common
- Gout is uncommon
If any of these persist or you consider them severe then inform doctor or pharmacist.
Tell your doctor immediately if you develop any of the following symptoms:
- Muscle cramps
- Passing little urine
- Abnormal heart beat
- Feeling or being sick
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.
Before taking chlortalidone, tell your doctor or pharmacist if you are allergic to it; or to other diuretics; or if you have any other allergies.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if:
- You have an allergy (hypersensitivity) to chlortalidone or sulfonamides or to any of the ingredients in the tablet
- You have severe liver problems
- You have severe kidney problems
- You have a failure to produce urine (anuria)
- You are pregnant or are breastfeeding
- You are undergoing an investigation into your parathryoid function
- You have low levels of potassium in your blood that can cause muscle weakness, muscle twitching or abnormal heart beat (hypokalaemia)
- You have levels of calcium in the blood that can cause loss of appetite, tiredness or muscle weakness (hypercalcaemia)
- You have low levels of sodium in the blood that can cause tiredness, confusion, muscle twitching, fits or coma (hyponatraemia)
- You have high levels of uric acid in the blood that is causing symptoms, such as gout or kidney stones (hyperuricaemia)
- You have a problem with your adrenal glands that results in inadequate production of natural steroid hormones (Addison's disease)
- You use a drug used to treat depression called lithium
- You have high blood pressure (hypertension) due to pregnancy
Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:
- Liver problems
- Kidney problems
- Heart problems
- High cholesterol levels
- History of gout
- Malnutrition (under-fed)
- Hereditary blood disorders called acute porphyrias
- A condition called systemic lupus erythematosus that causes inflammation and tissue damage in various parts of the body
Before having surgery, tell your doctor or dentist that you are taking this medication.
Does alcohol intake affect this drug?
- Alcohol make increase the affect of this drug.
The elderly: chlortalidone should be used with caution in the elderly as they are at greater risk of developing low levels of potassium in the blood.
Liver problems. Chlortalidone should be used with caution in those with liver problems as they are at greater risk of developing low levels of potassium in the blood and a complication of liver disorders that damages the brain and nervous system (hepatic encephalopathy).
Heart problems. Indapamide should be used with caution in those with heart conditions as they are at greater risk of developing an irregularity with their heart beat due to low levels of potassium in the blood. In addition, low levels of potassium increase the toxicity of digoxin, a common heart drug.
Gout. Chlortalidone should be used with caution in those who tend to get gout as the number of gout attacks may be increased.
Pregnancy and breastfeeding - please ensure you read the detailed information below
Chlortalidone is not safe to take if you are, or are planning to become, pregnant.
It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.
If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Chlortalidone is not safe to take if you are breastfeeding.
It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.
If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.
If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.
The following medicines may interact with chlortalidone:
- Lithium used to treat mental illness
- Medicines for high blood pressure (hypertension) and heart problems, such as ACE inhibitors (e.g. lisinopril), beta-blockers (e.g. propranolol), calcium channel blockers (e.g. amlodipine), methyldopa, vasodilators (e.g. bosentan), digoxin, and guanethidine
- A drug called adrenocorticotropic hormone that is used to treat a number of conditions, such as Crohn's disease, rheumatoid arthritis and inflammatory bowel disease (ulcerative colitis)
- Medicines for diabetes, such as insulin and metformin
- A type of medicine used for pain relief and inflammation called non-steroid anti-inflammatory drugs (NSAIDs)
- Medicines used to treat allergies and inflammatory diseases called corticosteroids (e.g. prednisolone and betamethasone)
- Medicines used to treat asthma, such as salbutamol and formoterol
- Amphotericin used to treat infections
- Colestyramine to help reduce cholesterol levels
- Carbenoxolone used to treat ulcers
- Drugs used to treat stomach spasms or cramps called anticholinergics, such as atropine sulphate and hyoscine butylbromide
- Allopurinol used to treat gout
- Amantadine used to treat Parkinson's disease or virus infections called
- Calcium salts or vitamin D
- Ciclosporine used to treat rheumatic disease, skin problems or after a transplant
This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.
If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.
If you take more chlortalidone than you should, tell your doctor or contract your nearest hospital casualty department immediately. Symptoms of overdose include dizziness, feeling sick, feeling sleepy, heart beat problems and muscle spasms.
If you think you, or someone you care for, might have accidentally taken more than the recommended dose of chlortalidone or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.