Boots WebMD Partners in Health
Return To Boots

Medicines & treatments centre

Terms Of Use

CHLORTALIDONE

Brand Name(s) : Hygroton
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

CHLORTALIDONE WARNINGS

Chlortalidone should be used with caution in:

It should not be used in:

  • Allergy (hypersensitivity) to chlortalidone, sulfonamides such as sulfamethoxazole or any ingredient in the tablet or other diuretics
  • Severe liver problems
  • Severe kidney problems
  • Failure to produce urine (anuria)
  • When parathryoid function is being investigated
  • When there are low levels of potassium in the blood that can cause muscle weakness, muscle twitching or abnormal heart beat (hypokalaemia)
  • High levels of calcium in the blood that can cause loss of appetite, tiredness or muscle weakness (hypercalcaemia)
  • Low levels of sodium in the blood that can cause tiredness, confusion, muscle twitching, fits or coma (hyponatraemia)
  • High levels of uric acid in the blood that is causing symptoms, such as gout or kidney stones (hyperuricaemia)
  • A problem with your adrenal glands that results in inadequate production of natural steroid hormones (Addison's disease)
  • A drug used to treat depression called lithium
  • High blood pressure (hypertension) due to pregnancy

Also see list of precautions and interactions

STORAGE

No special storage conditions are required.

CHLORTALIDONE USES

What is it used for?

Listed below are the typical uses of chlortalidone:

  • High blood pressure (hypertension)
  • Heart failure
  • Fluid collection in the stomach (ascites) due to cirrhosis of the liver
  • Fluid retention due to kidney disease (nephrotic syndrome)
  • Diabetes insipidus

HOW TO USE/TAKE

How often do I take it?

  • Always take chlortalidone tablets exactly as your doctor has told you. It is best to take the tablets in the morning with food. Swallow the tablets whole with a drink of water.
  • Use this medication for the duration of the prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • You should avoid low-saltdiets as the drug may reduce the amount of salt in your body. When you start to take chlortalidone, you may feel dizzy. If this happens, do not drive or operate machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.

CHLORTALIDONE SIDE EFFECTS

  • Low levels of potassium in the blood that cause muscle weakness, muscle twitching or abnormal heart beat is very common
  • High levels of uric acid in the blood (hyperuricaemia) is very common
  • An increase in cholesterol levels in the blood is very common
  • Low levels of sodium that can cause tiredness, confusion, muscle twitching, fits or coma (hyponatraemia) is common
  • High levels of sugar in blood (hyperglycaemia) is common
  • Low levels of magnesium (hypomagnesaemia) is common
  • Loss of appetite is common
  • Dizziness is common
  • Impotence is common
  • Skin rash is common
  • Feeling dizzy when moving from lying down to sitting or standing (postural hypotension) is common
  • Gout is uncommon

If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

CHLORTALIDONE PRECAUTIONS

Before taking chlortalidone, tell your doctor or pharmacist if you are allergic to it; or to other diuretics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if:

  • You have an allergy (hypersensitivity) to chlortalidone or sulfonamides or to any of the ingredients in the tablet
  • You have severe liver problems
  • You have severe kidney problems
  • You have a failure to produce urine (anuria)
  • You are pregnant or are breastfeeding
  • You are undergoing an investigation into your parathryoid function
  • You have low levels of potassium in your blood that can cause muscle weakness, muscle twitching or abnormal heart beat (hypokalaemia)
  • You have levels of calcium in the blood that can cause loss of appetite, tiredness or muscle weakness (hypercalcaemia)
  • You have low levels of sodium in the blood that can cause tiredness, confusion, muscle twitching, fits or coma (hyponatraemia)
  • You have high levels of uric acid in the blood that is causing symptoms, such as gout or kidney stones (hyperuricaemia)
  • You have a problem with your adrenal glands that results in inadequate production of natural steroid hormones (Addison's disease)
  • You use a drug used to treat depression called lithium
  • You have high blood pressure (hypertension) due to pregnancy

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Liver problems
  • Kidney problems
  • Heart problems
  • Diabetes
  • High cholesterol levels
  • History of gout
  • Elderly
  • Malnutrition (under-fed)
  • Hereditary blood disorders called acute porphyrias
  • A condition called systemic lupus erythematosus that causes inflammation and tissue damage in various parts of the body

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol make increase the affect of this drug.

The elderly: chlortalidone should be used with caution in the elderly as they are at greater risk of developing low levels of potassium in the blood.

Liver problems. Chlortalidone should be used with caution in those with liver problems as they are at greater risk of developing low levels of potassium in the blood and a complication of liver disorders that damages the brain and nervous system (hepatic encephalopathy).

Heart problems. Indapamide should be used with caution in those with heart conditions as they are at greater risk of developing an irregularity with their heart beat due to low levels of potassium in the blood. In addition, low levels of potassium increase the toxicity of digoxin, a common heart drug.

Gout. Chlortalidone should be used with caution in those who tend to get gout as the number of gout attacks may be increased.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Chlortalidone is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Chlortalidone is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

CHLORTALIDONE INTERACTIONS

Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with chlortalidone:

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.

CHLORTALIDONE OVERDOSE

If you take more chlortalidone than you should, tell your doctor or contract your nearest hospital casualty department immediately. Symptoms of overdose include dizziness, feeling sick, feeling sleepy, heart beat problems and muscle spasms.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of chlortalidone or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Find a medication

Search by medication name for information on over-the-counter or prescription medications including side effects and interactions.
indicates detailed medicines information

Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

Search for a medicine or treatment

Search by medicine name or treatment for information including side effects and interactions.

Ex. Simvastatin, Ibuprofen, Amitriptyline Hydrochlorine

Popular slideshows & tools on BootsWebMD

mature woman
Go for the glow!
avacado on whole wheat crackers
Plenty of healthy options
bowl of soup
Small changes that lead to weight loss
baby eating from spoon
What to feed your baby in the first year
cold sore
How to cope with cold sores
toddler doodling
What to expect in your child's second year
bain illustration
Best foods for your brain
bucket with cleaning supplies in it
Cleaning for a healthy home
mother and child
Could your baby be allergic to milk?
cute baby
Simple tips to keep baby's skin healthy