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Terms Of Use


Brand Name(s) : Frumil, Frumil LS
Side Effects


Co-amilofruse should be used with caution in:

It should not be used by:

  • People under 18 years of age
  • Women who are breastfeeding
  • Patients with low blood volume (hypovolaemia) or who are dehydrated (with or without low blood pressure)
  • People with severe liver or kidney problems
  • People with liver cirrhosis which is affecting the level of consciousness
  • People who are not producing urine (anuria)
  • People with high or low blood levels of potassium
  • People with Addison's disease (a disorder in which the adrenal glands do not produce enough steroid hormones).

Also see list of precautions and interactions.


No special storage conditions required.


What is it used for?

  • Co-amilofruse is used to treat a number of problems.
  • It is a type of diuretic, sometimes known as water tablets.
  • It is used to treat unwanted build-up of extra fluid in the body. This extra water can cause swollen ankles, shortness of breath and feeling more tired than usual.
  • In general this drug is used to treat fluid accumulation (oedema) owing to heart failure (fluid accumulates in the body as the heart is not pumping blood around the body as well as normal). lt can also be used to treat other conditions causing fluid to build up in the body such as certain liver and kidney disorders. As this drug is a diuretic (more specifically, containing a type of diuretic known as a potassium-sparing diuretic that does not cause the loss of potassium from the body), it removes water from the body by increasing the amount of urine that the kidneys produce. It contains two ingredients, furosemide and amiloride, which are both diuretics.
  • Benefits of being on this drug can include the prevention of fluid accumulation.

Listed below are the typical uses of co-amilofruse.

  • For use in situations where prompt diuresis (increased urination and water loss) is required.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • Take this medication by mouth, usually once daily in the morning. Tablets should be swallowed whole and taken with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This drug may cause dizziness. If affected in this way avoid driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: tiredness, together with throat or mouth ulcers; changes in eyesight or hearing; yellowing of the skin or eyes (jaundice).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking co-amilofruse, tell your doctor or pharmacist if you are allergic to it; or to other diuretics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: low blood volume (hypovolaemia) or dehydration (with or without low blood pressure), severe liver or kidney problems, not producing urine (anuria), high or low blood levels of potassium, or Addison's disease (a disorder in which the adrenal glands do not produce enough steroid hormones).

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following: any liver or kidney problems, prostate problems or difficulty passing water (urinating), diabetes, gout, low blood pressure (hypotension) or if at increased risk of hypotension, are likely to have an imbalance of blood electrolytes (e.g. potassium or sodium).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Avoid drinking alcohol with this drug as it may make certain side-effects such as low blood pressure more likely.

The elderly: co-amilofruse should be used with caution in the elderly as it may be more likely to cause dehydration in this age group.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Co-amilofruse is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Co-amilofruse is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with co-amilofruse:

  • Antibiotics (lymecycline)
  • Antipsychotics (pimozide)
  • Tacrolimus
  • Potassium supplements and potassium salts
  • Medicines for hypertension, such angiotensin-converting enzyme (ACE) inhibitors e.g. captopril, enalapril or ramipril, alpha blockers e.g. doxazosin, prazosin or terazosin, angiotensin-II receptor antagonists e.g. losartan, telmisartan or valsartan, or beta blockers e.g. sotalol
  • Medicines for depression such as reboxetine
  • Anti-arrhythmics, such as digoxin, disopyramide or flecainide
  • Antipsychotics, such as sertindole or amisulpride
  • Anti-epileptic, such as phenytoin or carbamazepine
  • Immunosuppressant drugs, such as ciclosporin and tacrolimus
  • Atomoxetine, used to treat attention deficit hyperactivity disorder (ADHD)

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


The effects of overdose with co-amilofruse are not known.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of co-amilofruse or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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