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Terms Of Use


Brand Name(s) : Motilium
Side Effects


Domperidone should be used with caution in:

  • Children
  • People over 60 years
  • Kidney problems
  • Patients with intolerance to certain sugars

It should not be used in:

Also see list of precautions and interactions


Do not store above 25°C.


What is it used for?

  • Domperidone is used to help to move food faster through your food pipe (oesophagus), stomach and gut. This is so that it does not stay in the same place for too long.
  • It is a dopamine agonist, and belongs to a group of medicines known as anti-emetics.
  • In general this drug is used to relieve symptoms of feeling sick (nausea) and sickness (vomiting).
  • Benefits of being on this drug can include relieving symptoms of nausea and vomiting.

Listed below are the typical uses of domperidone:

  • In adults, the treatment of feeling sick (nausea) or being sick (vomiting)
  • In children over 12 years and weighing over 35 Kg, the treatment of feeling sick (nausea) or being sick (vomiting).

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • Take this medication orally with water, as directed by your doctor. Domperidone should be used at the lowest effective dose, for the shortest possible duration.
  • Use this medication for the duration of prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to an hour before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines. Adults should not take more than three 10mg tablets per day.

Do I need to avoid anything?

  • Domperidone should have no effect on your ability to drive or use machinery. However, you may feel sleepy, confused or have less control over your movements while taking domperidone. If this happens, do not drive or use any tools or machines.
  • Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor. The maximum duration of treatment should not normally exceed one week.


  • Unusual production of breast milk in men and women,
  • breast enlargement in men and women,
  • lowering of sexual drive (libido) in men,
  • menstrual periods may be irregular or stop,
  • problems with vision,
  • development of a tremor,
  • imbalance.

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Stop using domperidone and tell your doctor immediately if you develop any of the following symptoms:

  • swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing, an itchy, lumpy rash (hives) or nettle rash (urticaria), heart rhythm disorders
  • Very fast or unusual heart beat, as this could be the sign of a life-threatening problem
  • uncontrolled movements, including: irregular eye movements, unusual movements of the tongue, and abnormal posture such as a twisted neck, trembling and muscle stiffness. This is more likely to happen in children.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking domperidone, tell your doctor or pharmacist if you are allergic to it; or to other dopamine agonists; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • allergies to domperidone or any of the other ingredients
  • tumour of the pituitary gland (prolactinoma)
  • stomach or duodenal ulcer
  • heart problems
  • frequent severe stomach cramps
  • a blockage, tear or perforated ulcer in your intestines
  • black, tarry bowel motions (stools) or notice blood in your bowel motions, this could be a sign of bleeding in the stomach or intestines
  • breast feeding
  • moderate or severe liver problems
  • severe kidney problems

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect domperidone.

The elderly: domperidone should be used with caution in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below


If you are pregnant or think you might be pregnant ask your doctor for advice before taking this medicine.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Domperidone is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with domperidone:

  • Antibiotics such as erythromycin, clarithromycin and telithromycin
  • Medicines used in HIV, such as telaprevir and ritonavir
  • Antifungals such as oral ketoconazole, fluconazole or variconazole
  • Antidepressants such as citalopram or escitalopram
  • Medicines for malaria especially halofantrine

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


If you think you, or someone you care for, might have accidentally taken more than the recommended dose of domperidone or intentional overdose is suspected, immediately contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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