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Brand Name(s) : Yentreve, Cymbalta
Side Effects


Duloxetine should be used with caution in: the elderly, patients with heart disease, epilepsy, those with kidney problems, previous or current mental diseases such as mania or psychoses, increased pressure in the eye (known as narrow-angle glaucoma), a history of bleeding disorders or use of drugs that increase the risk of bleeding disorders.

It should not be used in: women who are pregnant or likely to become pregnant or who are breastfeeding, those under 18 years of age, liver problems or severe kidney problems, patients who are taking a drug called a monoamine oxidase inhibitor (MAOI) within 14 days, are taking fluvoxamine (used to treat depression) or the antibioticsciprofloxacin, and in uncontrolled high blood pressure (hypertension).

Also see list of precautions and interactions.


Store below 30°C.


What is it used for?

Listed below are the typical uses of duloxetine.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • Take this medication orally, usually once or twice daily, with or without food. Tablets should be taken whole with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to several weeks or months before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Avoid drinking alcohol. Do not drive or operate machinery until you know if duloxetine affects your ability to perform these operations (it may cause drowsiness or dizziness). Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


Only the most common side effects have been listed. Further information about other side-effects can be found in the patient information leaflet.

If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: feeling more depressed or thinking about suicide; having a fit (seizure); blurred vision; any manic symptoms (e.g. rapid speech, racing thoughts, severely elevated mood [euphoria]).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking duloxetine, tell your doctor or pharmacist if you are allergic to it; or to other antidepressants; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: mental disorders (particularly schizophrenia or bipolar disorder), epilepsy, liver or kidney disease or any sort of heart or blood disorder, high blood pressure (hypertension), increased pressure in the eye (glaucoma), or if you are pregnant or likely to become pregnant or are breastfeeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any episodes of mania (overactive behaviour or thoughts), history of heart problems or high blood pressure, have previously had fits or any bleeding disorders (tendency to bruise very easily), or increased pressure in the eyes (glaucoma).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Possibly. Be careful when drinking alcohol whilst taking duloxetine.

The elderly: duloxetine can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below


The safety of duloxetine has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Duloxetine is not safe to take if you are breastfeeding

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • Other antidepressants (monoamine oxidase inhibitors [MAOIs], including the reversible MAOI, moclobemibe; and the selective serotonin reuptake inhibitor [SSRI], fluvoxamine)
  • Antibiotics (ciprofloxacin)
  • Antimalarial agents (artemether/lumefantrine)

If you are currently using any of these medications, tell your doctor or pharmacist before starting reboxetine.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Antidepressants (e.g. selective serotonin reuptake inhibitors [SSRIs] such as paroxetine, sertraline, citalopram, escitalopram and fluoxetine; tricarboxylic acid [TCA] antidepressants such as amitriptyline and clomipramine; venlafaxine; and the herbal medicine St John's wort
  • Blood-thinning drugs (e.g. warfarin)
  • Strong pain killers (e.g. tramodol or pethidine).

This information does not contain all possible interactions. Therefore, before using duloxetine, tell your doctor or pharmacist of all the products you use.


Symptoms of an overdose include: sleepiness, coma (unable to wake), fits, vomiting, tachycardia (fast heart beat), high blood pressure, dizziness, tremor, agitation, headache, diarrhoea and confusion.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of escitalopram or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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