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Terms Of Use


Brand Name(s) : Eccoxolac, Etopan XL, Lodine SR
Side Effects


Etodolac should be used with caution in: patients with a history of high blood pressure (hypertension); patients with mild to moderate congestive heart failure; patients with established ischaemic (decreased blood supply) heart disease; patients with peripheral arterial disease; patients with cerebrovascular disease (related to the blood vessels supplying the brain); patients with hyperlipidaemia (an excess of lipids in the blood); patients with diabetes mellitus; patients with kidney (renal), heart (cardiac) or liver (hepatic) impairment especially those taking diuretics and the elderly; patients with a history of gastrointestinal bleeding; pregnant woman or those attempting to conceive.

It should not be used in: patients with aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs); patients who have recently undergone heart bypass surgery; patients with severe heart failure; patients with active or recurring peptic ulcer or bleeding in the stomach; women in the last three months of pregnancy; children.

Also see list of precautions and interactions


Store below 25°C.


What is it used for?

Listed below are the typical uses of Etodolac:

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • Take this medication by mouth usually once or twice a day, with a full glass of water and preferably with or after food.
  • Modified release tablets must be swallowed whole and must not be crushed or chewed.
  • Use this medication for the duration of the prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Etodolac can cause dizziness, drowsiness, tiredness (fatigue) or abnormal vision. You need to be aware of how you react to this medicine before driving or operating machines. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.


  • Upset stomach
  • Diarrhoea
  • Wind
  • Nausea & vomiting
  • Constipation
  • Mouth ulcers
  • Fatigue (weakness)
  • Dizziness
  • Fever
  • Drowsiness
  • High blood pressure
  • Palpitations (throbbing of heart)
  • Heart disorders
  • Anaemia or other blood disorders
  • Unexpected bleeding
  • Headache
  • Ringing or buzzing in ears
  • Abnormal vision
  • Jaundice (yellowing of the eyes or skin)
  • Abdominal pain
  • Increased sensitivity to light
  • Skin rash, redness or itching of the skin

If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms: pass blood in your faeces (stools/motions); pass black tarry stools; vomit any blood or dark particles that look like coffee grounds; indigestion or heartburn; abdominal pain (pains in your stomach) or other abnormal stomach symptoms; urinary problems such as high blood pressure, feet swelling, passing little or no urine or passing blood (these might be a sign of kidney failure or toxicity).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking Etodolac, tell your doctor or pharmacist if you are allergic to it; or to other similar painkillers (NSAIDs); or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs); recent heart bypass surgery; severe heart failure; a peptic ulcer (a small erosion or hole in the stomach or duodenum) or bleeding in your stomach, two or more episodes of peptic ulcers, stomach bleeding or perforation; pregnancy or breast feeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: kidney disease; liver disease; poorly controlled diabetes; stomach/intestinal/oesophagus problems (e.g., bleeding, ulcers, recurring heartburn); heart disease (e.g., congestive heart failure, history of heart attack); stroke; high blood pressure; swelling (oedema, fluid retention); dehydration; blood disorders (e.g., anaemia); bleeding or clotting problems; asthma; growths in the nose (nasal polyps).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • You should limit the amount of alcohol you take whilst on this drug as it may increase the risk of stomach bleeding.

The elderly: etodolac should be used with caution in the elderly as it may increase the frequency of side effects, especially gastrointestinal bleeding and perforation which may be fatal.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Etodolac is to be avoided in the last trimester of pregnancy, as the onset of labour may be delayed and the duration increased with an increased bleeding tendency in both mother and child. It should also not be used in the first two trimesters unless the potential benefit to the patients outweighs the potential risk to the foetus.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Etodolac is not safe to take if you are breastfeeding, as it passes into the breast milk.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with etodolac:

  • Warfarin, for blood thinning
  • Ciclosporin or tacrolimus, following transplantation
  • Digoxin, for heart problems
  • Lithium, for mental illness
  • Methotrexate , used to treat conditions such as psoriasis or rheumatoid arthritis
  • Corticosteroids, such as prednisolone
  • Quinolone antibiotics e.g. ciprofloxacin
  • Aspirin
  • Other NSAIDs e.g. ibuprofen, naproxen, diclofenac
  • Medicines to control high blood pressure
  • Mifepristone (a medicine to induce abortion) in the last 12 days
  • Cardiac glycosides, for heart problems
  • Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs)
  • Zidovudine , used in the treatment of HIV infection and AIDS

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


Taking too much Etodolac, may cause the following: headache, nausea, vomiting, epigastric (upper abdomen) pain, gastrointestinal bleeding; Rarely: diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, ringing, buzzing in ears (tinnitus), fainting; Occasionally: convulsions. In cases of significant poisoning acute renal (kidney) failure and liver damage are possible

People who have taken too much Etodolac should seek medical help immediately and may possibly be given activated charcoal if within one hour of ingestion of a potentially toxic amount. Alternatively, in adults, gastric lavage (stomach pump) should be considered within one hour of indigestion of a potentially life-threatening overdose.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of Etodolac or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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