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EZETIMIBE (EZETROL)

Brand Name(s) : Ezetrol, Inegy (in combination with simvastatin)
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

EZETIMIBE WARNINGS

Ezetimibe should be used with caution in: patients who have mild liver problems and children under 10 years of age.

It should not be used in: patients with severe liver problems, or with any active liver disease (when given together with a statin), women who are pregnant or who are breastfeeding children (when given together with a statin).

Also see list of precautions and interactions.

STORAGE

Store below 30°C

EZETIMIBE USES

What is it used for?

  • Ezetimibe is used to treat a number of problems.
  • It is a member of a class of lipid-modifying drugs, sometimes known as selective cholesterol absorption inhibitors.
  • It is used to modify levels of lipids (fats) in the blood.
  • In general this drug is used to reduce high levels of lipids such as low-density lipoprotein cholesterol (LDL-C) in the blood, but is also used to reduce high levels of other blood lipids such as triglycerides, or to increase levels of a type of cholesterol that protects against heart disease and stroke (high-density lipoprotein cholesterol, or HDL-C).
  • Benefits of being on this drug include reducing the likelihood of cardiovascular disease events (e.g. heart attacks, stroke) and prolonged life.

Listed below are the typical uses of ezetimibe.

  • Treating a range of conditions involving abnormal blood cholesterol levels (e.g. primary hypercholesterolaemia), together with a statin or alone (if a statin in not appropriate or is not tolerated) in conjunction with diet
  • Treating hereditary illnesses involving abnormal blood cholesterol levels (e.g. familial hypercholesterolaemia) in combination with a statin and in conjunction with diet

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally, usually once daily at any time of day, with or without food.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take few weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Ezetimibe may cause dizziness, so patients should not drive or use machines if they are affected.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

EZETIMIBE SIDE EFFECTS

Only the most common side effects have been listed. If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: unexplained muscle aches and pains, tenderness, weakness or cramps, particularly if you also feel generally unwell and/or have a fever.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

EZETIMIBE PRECAUTIONS

Before taking ezetimibe, tell your doctor or pharmacist if you are allergic to it; or to other lipid-modifying drugs or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver problems, any active liver disease (when ezetimibe is given together with a statin), are a women who is pregnant or is breastfeeding, or if you have muscle pains, cramps or muscle tenderness or weakness.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any previous liver problems, any previous unexplained muscle pains, cramps or muscle tenderness or weakness.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Not known.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of ezetimibe has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Ezetimibe is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

EZETIMIBE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • None.

If you are currently using any of these medications, tell your doctor or pharmacist before starting ezetimibe.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • The immunosuppressant (ciclosporin)
  • Lipid-modifying drugs (fibrates such bezafibrate, ciprofibrate, fenofibrate or gemfibrozil), resins such as the anion-exchange resins, colestipol or colestyramine)
  • Blood-thinning agents (e.g. warfarin or acenocoumarol).

This information does not contain all possible interactions. Therefore, before using ezetimibe, tell your doctor or pharmacist of all the products you use.

EZETIMIBE OVERDOSE

Few cases of overdose with ezetimibe have been reported, but most were not associated with adverse effects.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of ezetimibe or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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