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Brand Name(s) : Euglucon
Side Effects


Glibenclamide should be used with caution in:

  • Elderly patients
  • People with decreased kidney function
  • People with decreased liver function
  • People taking certain medications to treat high blood pressure, infections and other conditions (see interactions)
  • Obese people (as this drug encourages weight gain)

It should not be used in:

Also see list of precautions and interactions


This medication should be stored in a cool dry place.

Do not store above 25°C.


What is it used for?

Listed below are the typical uses of glibenclamide.

  • Type 2 (non-insulin dependent) diabetes, when diet has not sufficiently controlled the blood sugar levels.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • Take this medication by mouth usually once daily, with or immediately after breakfast, or the first main meal of the day.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to a few hours before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • If you have low blood sugar levels then avoid driving or operating machinery. Consult your doctor or pharmacist for more details.
  • You should avoid taking alcohol with this drug, as it may cause troublesome effects and affect the way the drug works.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop. Always complete the full course as prescribed by your doctor.


If any of these persist or you consider them severe then inform doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Yellowing of eyes and skin (signs of liver problems)
  • Skin rash or itching

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking glibenclamide, tell your doctor or pharmacist if you are allergic to it; or to other sulfonylureas; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have/are:

  • Allergy to glibenclamide, or any of its ingredients
  • Severe liver problems
  • Severe kidney problems
  • In, or history of diabetic coma
  • Severe thyroid problems
  • Severe adrenal gland problems
  • Surgery, severe infection or trauma
  • Porphyria (inherited blood disorder)
  • Juvenile diabetes
  • Diabetic ketoacidosis (complication of diabetes with body producing ketone bodies)
  • Pregnant
  • Breastfeeding
  • Taking a medicine called bosentan

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Decreased kidney function
  • Decreased liver function

Before having surgery, tell your doctor or dentist that you are taking this medication. Inform your doctor if you have a serious accident or severe infection which may affect your diabetes.

Does alcohol intake affect this drug?

  • Alcohol intake is not recommended while taking this medication as it can affect the blood sugar levels.

The elderly: glibenclamide should be used with caution in the elderly as it may increase the risk of hypoglycaemia (low blood sugar levels).

Pregnancy and breastfeeding - please ensure you read the detailed information below


Glibenclamide is not safe to take if you are, or are planning to become, pregnant. During pregnancy, it is preferred to control diabetes through the use of insulin.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


It is not known whether glibenclamide passes into breast milk. The manufacturer therefore states that it should not be taken if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occurbosentan (used to treat high blood pressure in the lungs blood vessels).

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • Medications for high blood pressure such as
    -ACE inhibitors e.g. captopril
    -Beta-blockers e.g. propranolol (including eye drops)
  • Medications to treat infections such as -Chloramphenicol
    -Fluconazole (fungal infections)
    -Miconazole (fungal infections)
    -Rifampicin (for tuberculosis)
    -Voriconazole (fungal infections)
  • Coumarins (to stop blood clotting) such as warfarin
  • Some types of painkiller known as non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin
  • Sulfinpyrazone (for gout)
  • Topiramate (for epilepsy)
  • Cimetidine (for ulcers and indigestion)
  • Fibrates (for high cholesterol) such as clofibrate
  • Lanreotide (for hormone producing tumours)
  • Monoamine oxidase inhibitors (MAOIs; for depression such as moclobemide and phenelzine
  • Octreotide (for hormone producing tumours)
  • Phenothiazines (some anti-psychotics to treat psychoses such as schizophrenia and some antihistamines to treat allergies)
  • Anabolic steroids such as testosterone
  • Corticosteroids such as hydrocortisone
  • Diuretics (increases urine output), such as thiazide diuretics e.g. bendroflumethiazide
  • Oestrogens, progestogens (e.g. oral contraceptives)

This information does not contain all possible interactions. Therefore, before using glibenclamide, tell your doctor or pharmacist of all the products you use.


If you think you, or someone you care for, might have accidentally taken more than the recommended dose of glibenclamide or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember with your next meal. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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