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Terms Of Use

LAMOTRIGINE

Brand Name(s) : Lamictal
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

LAMOTRIGINE WARNINGS

Lamotrigine should be used with caution in:

It should not be used in:

  • People with allergy to lamotrigine, or any of its ingredients
  • Children, under 2 years of age

Also see list of precautions and interactions

STORAGE

Keep your medication in a dry, safe place where children cannot see or reach them. They should be stored below 30°C.

Do not take any tablets after the end of the month shown on the pack.

LAMOTRIGINE USES

What is it used for?

  • Lamotrigine is used to treat epilepsy
  • It is an anticonvulsant, sometimes known as anti-epileptic drug.
  • It is used to treat fits (seizures) which result from having epilepsy.
  • In general this drug is used as either monotherapy (on its own) or in combination with other anti-epileptic drugs to treat various types of epilepsy in both children and adults.
  • Benefits of being on this drug can include a reduction in the number of seizures for people with epilepsy.

Listed below are the typical uses of lamotrigine.

  • Primary generalised tonic-clonic seizures
  • Secondary generalised tonic-clonic seizures
  • Partial seizures (both simple and complex)
  • Seizures associated with Lennox-Gastaut syndrome (severe childhood epilepsy)
  • Typical absence seizures in children

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

HOW TO USE/TAKE

Take this medication orally usually once or twice daily, with or without food. Lamotrigine tablets should be swallowed whole with a little water. Lamotrigine dispersible tablets may be chewed, dispersed in a small volume of water (at least enough to cover the whole tablet) or swallowed whole with some water.

Use this medication regularly in order to get the most benefit from it.

Remember to use it at the same time each day - unless specifically told otherwise by your doctor.

It may take some weeks before the full benefit of this drug takes effect.

Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication may cause dizziness or changes in vision. Due to individual changes in response to this medication your doctor should be consulted before driving or operating machinery. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop. Always complete the full course as prescribed by your doctor. Abruptly stopping your medication may result in your symptoms worsening and an increase in side effects. If your medication is stopped, your doctor will gradually decrease the medication over a period of time.

LAMOTRIGINE SIDE EFFECTS

If any of these persist or you consider them severe then inform the doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • Skin rash, all patients (both adults and children) should immediately see a doctor if a skin rash appears. The incidence may be higher in children than in adults. In children the initial presentation of a rash can sometimes be mistaken as an infection.
  • Symptoms of hypersensitivity syndrome which include fever, swollen lymph nodes, swelling of the face and changes to blood and liver. Early indications of hypersensitivity syndrome may be present without a rash.
  • Bruising, dark spots or marks on skin, unexplained bleeding, sore throat, mouth ulcers, high temperature, tiredness or more infection such as colds.
  • Abnormal thoughts of suicide or self-harm
  • Yellowing of eyes or skin

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

LAMOTRIGINE PRECAUTIONS

Before taking lamotrigine, tell your doctor or pharmacist if you are allergic to it; or to other anti-epileptic medication; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you are: allergic to lamotrigine or any of its ingredients, pregnant, women planning on becoming pregnant, breastfeeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • previous allergy to anti-epileptic medication, reduced kidney function, reduced liver function, Parkinson's disease, use of hormonal contraceptives, use of hormonal replacement therapy

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect lamotrigine.

The elderly: lamotrigine can be used in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

Talk to your doctor if you are, or are planning to become, pregnant. The use of this medicine during pregnancy is not recommended and you should only use it if your doctor thinks that you need it.

This medicine can affect the way the oral contraceptive pills work (see interactions). Discuss a suitable method of contraception with your doctor

Please consult your doctor for specific advice if you are planning on becoming pregnant, or have discovered you are pregnant as this medication can affect the unborn baby. However abruptly stopping your medication may result in your symptoms worsening which can affect both mother and unborn baby.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

Lamotrigine passes into breast milk and may affect your baby.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

LAMOTRIGINE INTERACTIONS

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: None Known

If you are currently using any of these medications, tell your doctor or pharmacist before starting lamotrigine.

Use of lamotrigine and contraceptives.

  • Hormonal contraceptives, such as the 'pill' can reduce the effectiveness of the medication in controlling seizures. Lamotrigine can also affect the effectiveness of hormonal contraceptives in the prevention of pregnancy. Therefore the use of hormonal contraceptives and lamotrigine is not recommended. Women are encouraged to use non-hormonal contraceptives, such as condoms. The use of hormonal contraceptives as the only method of contraception should only be used if there is no alternative. Women taking lamotrigine and who are considering starting or stopping the use of hormonal contraceptives should consult their doctor as dose adjustment of lamotrigine may be required.
  • The use of hormonal replacement therapy has not been studied, but is thought to have similar reactions to hormonal contraceptives.
  • Consult your doctor for advice.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:

  • People using hormonal contraceptives (see above)
  • People using hormonal replacement therapy (see above)
  • People taking anti-epileptic medication, such as:
  • Valproate
  • Carbamazepine
  • Phenytoin
  • Primidone
  • Phenobarbital
  • Oxcarbazepine
  • Atazanavir
  • Ritonavir
  • Saquinavir
  • Desmopressin
  • Orlistat
  • People taking rifampicin medication
  • People taking olanzapine (used for depression)

This information does not contain all possible interactions. Therefore, before using lamotrigine, tell your doctor or pharmacist of all the products you use.

LAMOTRIGINE OVERDOSE

Overdose may result in symptoms such as abnormal eye movements (nystagmus), lack of coordination and balance (ataxia), impaired consciousness and coma.

In the event of overdosage, the patient should be admitted to hospital and given appropriate supportive therapy.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of lamotrigine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Missing doses may result in seizures.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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