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Brand Name(s) : Istin, Amlostin
Side Effects


Amlodipine should be used with caution in: patients with liver problems, those with heart failure, children under the age of 18 years, or the elderly.

It should not be used in: patients with very low blood pressure making them feel faint or dizzy, patients who are in shock (including shock because of heart disease, termed cardiogenic shock), patients with poor heart function because of severe heart disease or a heart attack, patients with heart failure because of a heart attack, those with narrowing of the heart valve of the aorta (aortic stenosis), or patients with unstable angina (angina is a chest pain occurring when the heart muscle is not getting enough blood).

Also see list of precautions and interactions.


Store below 25ºC.


Amlodipine is used to lower blood pressure by relaxing the blood vessels so that blood passes through them more easily. In patients with chest pain (angina), amlodipine improves the blood flow to the heart muscle allowing it to receive more oxygen and preventing the occurrence of chest pain. However, amlodipine will not provide immediate relief from chest pain caused by angina.

It is a calcium antagonist, sometimes known as a calcium-channel blocker.

It is used to lower blood pressure and prevent the onset of chest pain associated with angina.

In general this drug is used for high blood pressure (hypertension) and for chest pain from angina (including the rare forms - Prinzmetal's or variant angina).

Benefits of being on this drug can include the prevention of chest pain from angina and a reduction in blood pressure.

Listed below are the typical uses of amlodipine.


How often do I take it?

  • Take this medication orally, usually once daily with a drink of water, with or without food.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • If amlodipine causes you to feel sick, tired, dizzy or gives you a headache, these symptoms could affect your ability to concentrate. Make sure you are not affected before driving or operating machinery. Consult your doctor or pharmacist for more details.
  • Grapefruit or grapefruit juice should not be consumed by people taking amlodipine. Grapefruit and grapefruit juice can lead to an increase in the blood levels of amlodipine, which can result in an unpredictable variation in blood pressure.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


Tho most common side effects are:

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms or contact the casualty department at your nearest hospital immediately and stop taking the medicine: swelling of the face, lips, tongue or/and the throat, difficulty breathing or swallowing, itching, rash, peeling of the skin, extensive reddening and blistering of the skin. These symptoms may be caused by a very rare allergic reaction called Stevens-Johnson's syndrome.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking amlodipine, tell your doctor or pharmacist if you are allergic to it; or to other calcium antagonists; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: very low blood pressure making you feel faint or dizzy, are in shock or have cardiogenic shock (shock because of heart disease), poor heart function because of severe heart disease or a heart attack, heart failure because of a heart attack within the last 28 days, narrowing of the heart valve of the aorta (aortic stenosis), unstable angina (angina is chest pain occurring when the heart muscle is not getting enough blood)

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: heart failure, or any liver problems.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol intake is not known to affect amlodipine.

The elderly: the recommended dosage of amlodipine is the same in the elderly as for younger patients. However, extra care should be taken when increasing the dose in the elderly.

Pregnancy and breastfeeding - please ensure you read the detailed information below.


Amlodipine is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Amlodipine is not safe to take if you are breastfeeding

Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with amlodipine:

  • Diltiazem, verapamil (for angina)
  • Ketoconazole, itraconazole (for fungal infections)
  • Ritonavir, indinavir, nefinavir (for viral infections)
  • Rifampicin (a medicine to treat tuberculosis)
  • Erythromycin, clarithromycin (antibiotics)
  • Dantrolene (infusion for severe body temperature abnormalities)
  • St John's Wort (a herbal medicine)
  • Any other medicines to treat high blood pressure including ACE inhibitors (e.g. captopril, enalapril, lisinopril, ramipril), beta blockers (e.g. atenolol, metoprolol or propranolol), other calcium antagonists (e.g. nifedipine, verapamil), diuretics which are also called water tablets (e.g. bendroflumethiazide or furosemide)

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


Symptoms of an overdose include flushing (reddening of the skin), feeling dizzy or fainting. If you or someone else swallow a lot of the tablets all together, or if you think a child has swallowed any of the tablets, contact your nearest hospital casualty department or doctor immediately. Take any remaining tablets and the packaging with you to the doctor or casualty department.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of amlodipine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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