Lisinopril should be used with caution in: patients (particularly when starting lisinopril therapy) who are currently taking diuretics or with heart failure or kidney problems, those who are on a low-salt diet, and those undergoing dialysis, narrowing of some blood vessels in the heart or a narrowing of the heart valves, narrowing of the kidney artery, hypertrophic cardiomyopathy (enlarged heart muscle), patients with collagen vascular disease (deposits of collagen in the blood vessels) such as scleroderma or systemic lupus erythematosus, high blood sugar levels (diabetes), patients who are dehydrated (have lost a lot of fluid) because they have recently been sick or had diarrhoea, patients who are having or are about to have low density lipoprotein apheresis treatment (removal of cholesterol from the blood by a machine).
It should not be used in: patients who are allergic to lisinopril, other ACE inhibitors or to any other ingredients in the medicine, children aged under 6 years, women who are pregnant, likely to become pregnant, or who are breastfeeding, patients with angioedema (indicated by puffiness or swelling of the face, tongue or body) with or without ACE inhibitor treatment, or patients with a family member who has experienced these symptoms.
Also see list of precautions and interactions.
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Lisinopril is used to treat a number of problems.
It is a member of a class of drugs called angiotensin-converting enzyme inhibitors, usually known as ACE inhibitors.
In general, this drug is used to lower blood pressure and to treat patients shortly after a heart attack. It is used to block the action of angiotensin converting enzyme (ACE) which is produced naturally in the body. ACE produces angiotensin II in the body, a compound which increases the pressure within the blood vessels by constricting and narrowing the vessels. By blocking ACE, lisinopril reduces the production of angiotensin II, which allows the blood vessels to relax and widen. This produces a drop in blood pressure. Because lisinopril also allows the heart to pump blood more easily around the body it is also useful for heart failure, a condition in which the heart does not pump blood around the body as efficiently as it should.
Benefits of being on this drug include reducing blood pressure, treating heart failure and slowing down the weakening of the heart after a heart attack.
Listed below are the typical uses of lisinopril:
However on occasion your doctor may prescribe this medicine to treat a condition not on this list:
HOW TO USE/TAKE
How often do I take it?
- This medication is available as a tablet, which should be taken orally, usually as a single dose every day, with or without food.
- Use this medication regularly in order to get the most benefit from it.
- Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
- It may take some time before you notice any benefits of this drug.
- Certain medical conditions may require different dosage instructions as directed by your doctor.
- Dosage is based on your age, gender, medical condition, response to therapy and use of certain interacting medicines.
Do I need to avoid anything?
- Avoid drinking alcohol as this can increase the blood-pressure lowering effect of lisinopril. If you feel tired or dizzy do not drive or operate machinery. Consult your doctor or pharmacist for more details.
When can I stop?
- It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
LISINOPRIL SIDE EFFECTS
- Feeling sick (nausea)
- Feeling faint or dizzy when standing up
- Heart attack or stroke
- Irregular heart beat (arrhythmia)
- Fast heart beat (tachycardia)
- Angina (pain in the chest owing to the poor blood supply to the heart)
- Stomach pain
- Severe abdominal pain (caused by an inflammation of the pancreas)
- Dry mouth
- Inflammation of the liver (hepatitis)
- Yellowing of skin and whites of the eyes (jaundice)
- Tingling, numbness or 'pins and needle' sensations (paraesthesia)
- Difficulty sleeping (insomnia)
- Bronchospasm (muscle bands around the airways tighten uncontrollably, causing the airways to narrow)
- Bronchitis (inflammation of the airways)
- Itchy rash
- Hair loss
- Red patches on skin
- Stevens-Johnson syndrome (serious blistering of the skin, mouth, eyes and private parts)
- Kidney failure
- Blurred vision
- Taste disturbances.
If any of these persist or you consider them severe then inform your doctor.
Tell your doctor immediately if you develop any of the following symptoms: angioedema (indicated by puffiness or swelling of the face, tongue or body); severe skin disorders including sudden unexpected rash or burning, red or peeling skin; high temperature associated with tiredness loss of appetite, feeling sick, yellowing of the skin or eyes.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.
Before taking lisinopril, tell your doctor or pharmacist if you are allergic to it; or to other angiotensin-converting enzyme (ACE) inhibitors; or if you have any other allergies.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: an allergy to lisinopril, other ACE inhibitors or to any other ingredients in the medicine, previous swelling of the legs, arms, face, mucous membranes or tongue and/or throat (angioedema) with or without ACE inhibitor treatment or you have a family member who has experienced these symptoms, pregnancy or breastfeeding.
Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: kidney disease, liver disease, heart failure, dialysis, treatment for hypersensitivity to bee or wasp stings (hyposensitisation), collagen vascular disease (deposits of collagen in the blood vessels) such as scleroderma or systemic lupus erythematosus, high blood sugar levels (diabetes), narrowing of some blood vessels in the heart, cardiomyopathy (enlarged heart muscle), treatment with water tablets (diuretics), you are dehydrated (have lost a lot of fluid) because you have recently been sick or had diarrhoea, low salt diet, you are having or are about to have low density lipoprotein apheresis treatment (removal of cholesterol from the blood by a machine).
Before having surgery, tell your doctor or dentist that you are taking this medication.
Does alcohol intake affect this drug?
- Yes. Avoid drinking alcohol whilst taking lisinopril.
Pregnancy and breastfeeding - please ensure you read the detailed information below
Lisinopril is not recommended in early pregnancy and must not be taken if you are more than 3 months pregnant. Ask your doctor or pharmacist if you have any doubts or questions about this.
It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.
If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Lisinopril is not recommended to take if you are breastfeeding. Ask your doctor or pharmacist if you have any doubts or questions about this.
It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.
If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.
This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:
If you are currently using any of these medications, tell your doctor or pharmacist before starting lisinopril.
Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:
- Other drugs that lower blood pressure (e.g. beta blockers such as atenolol, or diuretics)
- Substances affecting potassium levels (e.g. potassium salts, potassium supplements, potassium-sparing diuretics)
- Gold injections (e.g. sodium aurothiomalate)
- Water tablets (diuretics)
- Diabetes drugs (e.g. insulin and metformin)
- Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g. aspirin, paracetamol or indometacin)
- Ephedrine, noradrenaline and adrenaline (for low blood pressure, heart problems, asthma and allergies)
- Immunosuppressants (e.g. prednisolone or ciclosporin)
- Treatments for mental disorders (e.g. lithium and any antipsychotics)
- Allopurinol (used for treatment of gout).
- Antacids (for relief of indigestion).
This information does not contain all possible interactions. Therefore, before using lisinopril, tell your doctor or pharmacist of all the products you use.
No specific symptoms reported. There is no information on overdosage in people, but the most likely result of an overdose would be low blood pressure dizziness and fainting.
If you think you, or someone you care for, might have accidentally taken more than the recommended dose of lisinopril or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.