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Terms Of Use


Brand Name(s) : Mirapexin
Side Effects


Pramipexole should be used with caution in:

  • People with kidney disease
  • People with severe heart or blood vessel problems
  • People with any eye conditions
  • People with a mental illness such as schizophrenia
  • People taking antipsychotics used to treat mental illness (should be avoided if possible)
  • People taking alcohol or other medicines which cause sleepiness or certain other medications (see interactions)

It should not be used in:

  • Children (under 18 years old)
  • People with known hypersensitivity (allergy) to pramipexole or any of the other ingredients in the medication

Also see list of precautions and interactions


Do not store above 30°C.
Store in the original package in order to protect from light.


What is it used for?

  • Pramipexole is used to treat Parkinson's disease and restless legs syndrome.
  • It is a dopaminergic agonist.
  • It is used to treat Parkinson's disease. This is a disease characterised by stiff muscles, tremor and slow movement. Pramipexole stimulates the dopamine receptors in the brain and this helps alleviate the symptoms of Parkinson's disease. Pramipexole can be used alone or in combination with levodopa to treat Parkinson's disease. It is also used in the short-term treatment of restless legs syndrome.
  • In general this drug is used to treat people with Parkinson's disease.
  • Benefits of being on this drug can include an improvement in the symptoms of Parkinson's disease of slow movements, stiff muscles and tremor. It also relieves the symptoms of restless legs when given for up to 12 weeks.

Listed below are the typical uses of pramipexole.

  • Parkinson's disease
  • Restless legs syndrome (moderate to severe)

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.


How often do I take it?

  • For Parkinson's disease take this medication by mouth usually 3 times daily, with or after food. Swallow the tablets with a glass of water.
  • For Restless Legs syndrome take this medication by mouth usually once daily, 2 to 3 hours before bedtime, with or after food. Swallow the tablets with a glass of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • It may take up to a few weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medication can cause excessive drowsiness or sudden onset of sleep. Do not drive or operate machinery until you are sure that you are not affected in this way. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
  • For Parkinson's disease you must not stop taking this medication abruptly as there is a risk of serious side effects if you do so. You may develop a condition known as neuroleptic malignant-like syndrome. Signs include increased shaking, high temperature, stiff muscles, balance problems, rapid heart rate and mental changes.

The treatment of restless legs syndrome is reviewed after 3 months. Your doctor will then decide whether or not to continue treatment.


Pramipexole for Parkinson's disease:

Pramipexole for restless legs syndrome:

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • High fever alone or in combination with stiff muscles, change in mental state, rapid breathing and rapid heart rate as these may be signs of a serious, but rare condition known as neuroleptic malignant syndrome.

Tell your doctor if you develop any of the following symptoms:

  • Hallucinations (seeing, hearing or feeling things that are not there), abnormal, uncontrolled movements of the limbs, sleepiness and sudden episodes of falling asleep, any behavioural changes such as compulsive gambling, compulsive shopping, binge eating or interest in sex, abnormal thoughts or any problems with your eyesight.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking pramipexole, tell your doctor or pharmacist if you are allergic to it; or to other dopaminergic drugs; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Known hypersensitivity (allergy) to pramipexole or any of the other ingredients in the medication

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following:

  • Kidney disease
  • Severe heart or blood vessel problems
  • Eye or vision problems
  • Mental illness such as schizophrenia

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol should be used with caution with pramipexole due to the additional sedative side effects.

The elderly: pramipexole should be used in caution in the elderly as it may be more likely to cause side effects.

Pregnancy and breastfeeding - please ensure you read the detailed information below


The safety of pramipexole has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Pramipexole is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following may interact with pramipexol:

  • Alcohol
  • Medicines for anxiety and sleeping problems, such as zopiclone, diazepam and nitrazepam
  • Sedating antihistamines, used for allergies such as chlorphenamine, promethazine
  • Amantadine used to treat Parkinson’s disease and some viral infections
  • Cimetidine used to treat stomach ulcers
  • Zidovudine
  • Cisplatin
  • Quinine
  • Medicines known as antipsychotics used to treat mental health problems such as amisulpride, chlorpromazine, haloperidol, flupentixol and risperidone

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


Taking too much pramipexole may cause the following: nausea, vomiting, excessive movement, hallucinations, restlessness and feeling faint or dizzy due to low blood pressure.

People who have taken too much pramipexole, should talk to a doctor or go to a hospital straight away. Take the medicine pack with you. There is no established antidote for overdosage of a dopamine agonist.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of pramipexole or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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