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Terms Of Use


Brand Name(s) : Buccastem, Stemetil
Side Effects


Prochlorperazine maleate should be used with caution in:

It should not be used in:

  • allergy to prochlorperazine maleate or any of the other ingredients,
  • coma,
  • liver disease,
  • a tumour on the adrenal gland called phaeochromocytoma.

Also see list of precautions and interactions.


Protect from light. Store in the original container.


What is it used for?

  • Prochlorperazine maleate is used to balance the effects of natural chemicals in the brain called neurotransmitters.
  • It is a type of drug known as a phenothiazine.
  • It is used to relieve nausea (feeling sick) and vomiting (being sick) from any cause, and treat migraines and dizziness.
  • In general this drug is used to treat nausea and vomiting, the symptoms of vertigo (dizziness and balance problems) and migraines.

Listed below are the typical uses of prochlorperazine maleate.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.


How often do I take it?

  • You must follow the instructions that your doctor has given you about how much and when to take prochlorperazine maleate.
  • Tablets should be taken by mouth.
  • The buccal preparation should be taken by placing the tablet high up along the top gum under the upper lip either side of your mouth and allow it to dissolve slowly and completely. The tablet will soften and stick to the gum and may take up to 2 hours to dissolve completely. Most people find that after a few minutes they no longer notice the tablet. The tablet should not be moved about the mouth with the tongue as this will cause it to dissolve more quickly.
  • See the patient information leaflet for more details on how to take your medication.
  • Use this medication for the duration of prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Do not drive or operate machinery if affected by drowsiness while using this medication. Do not drink alcohol while you are taking prochlorperazine maleate. This is because alcohol can add to the effects of the medication and can cause serious breathing difficulties. Consult your doctor or pharmacist for more details.
  • Prochlorperazine maleate can make your skin more sensitive to sunlight. Avoid direct exposure to sunlight while taking this medicine.

When can I stop?

  • Always complete the full course as prescribed by your doctor.


  • Drowsiness,
  • dizziness,
  • dry mouth,
  • insomnia (difficulty sleeping),
  • agitation,
  • low blood pressure,
  • mild skin reactions,
  • jaundice,
  • problems with eyesight,
  • blood problems,
  • swelling of the breasts,
  • abnormal production of breast milk in men and women,
  • abnormal movements, tremors unusual movements of the face and tongue,
  • local irritation to the gum and mouth,
  • loss of menstrual periods,
  • difficulty in getting or maintaining an erection (impotence),
  • restlessness,
  • your skin being more sensitive to the sun than usual,
  • stuffy nose,
  • skin redness, swelling and itching from touching the medicine.
If any of these persist or you consider them severe then inform your doctor immediately.

Stop taking prochlorperazine maleate and see a doctor or go to a hospital straight away if you develop any of the following symptoms:

  • high temperature, pale complexion, muscle stiffness, fast heartbeat and changes in levels of alertness (symptoms of a serious condition called neuroleptic malignant syndrome),
  • an allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue,
  • frequent infections such as fever, sore throat or mouth ulcers,
  • yellowing of your skin or eyes (jaundice),
  • very fast, uneven or forceful heartbeats (palpitations),
  • breathing problems such as wheezing, shortness of breath, tightness in the chest and chest pain.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking prochlorperazine maleate, tell your doctor or pharmacist if you are allergic to it; or to other phenothiazines; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • allergy to prochlorperazine maleate or any of the other ingredients,
  • liver disease,
  • a tumour on the adrenal gland called phaeochromocytoma.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • the elderly,
  • pregnancy or breast feeding,
  • epilepsy,
  • Parkinson's disease,
  • prostate gland problems,
  • susceptibility to angle-closure glaucoma,
  • heart problems or a family history of heart problems,
  • patients who have had a stroke,
  • kidney disease,
  • thyroid problems,
  • dementia,
  • depression,
  • muscle weakness called myasthenia gravis,
  • patients with blood problems.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Do not drink alcohol while taking prochlorperazine maleate.

The elderly: prochlorperazine maleate should be used with caution in the elderly, who may be prescribed a lower dose. Care should be taken careful during very hot or very cold weather to make sure that elderly people do not get too hot or too cold when taking this medicine.

Pregnancy and breast-feeding - please ensure you read the detailed information below


Prochlorperazine maleate is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Prochlorperazine maleate is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with prochlorperazine:

  • Sedatives, used to help with sleep problems
  • Anti-depressants
  • Medicines used for Parkinson’s disease such as levodopa
  • Anti-epileptic drugs such as carbamazepine
  • Medicines used to control your heartbeat such as amiodarone, disopyramide, propranolol or quinidine
  • Medicines used to treat high blood pressure such as doxazosin, terazosin, guanethidine or clonidine
  • Medicines used to treat diabetes
  • Medicines used for cancer
  • Antibiotics
  • Antacids for indigestion and heartburn
  • Anticholinergic medicines, including some medicines used for irritable bowel syndrome, asthma or incontinence
  • Amphetamines used for Attention Deficit Hyperactivity Disorder (ADHD)
  • Adrenaline - used for life threatening allergic reactions,
  • Desferroxamine - used when you have too much iron in your blood
  • Lithium, used for some types of mental illness.

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


If you think you, or someone you care for, might have accidentally taken more than the recommended dose of prochlorperazine maleate or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you forget to take a dose it is not necessary to double the dose next time. Just carry on taking the medicine at the recommended dose. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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