Quinapril should be used with caution in: the elderly, kidney disease, liver disease, patients who use a haemodialysis machine (artificial kidney), heart disease, disease of the circulatory system, deposits of collagen in the blood vessels (collagen vascular disease), patients who are having or are about to have low density lipoprotein apheresis treatment (removal of cholesterol from the blood by a machine), allergies and asthma, patients who are about to have or are having desensitisation treatment to reduce the effects of an allergy, diabetes, renal artery stenosis (narrowing of the blood vessels to the kidneys), low sodium diet, intolerance to certain sugars.
It should not be used in:
- patients who have an allergy to quinapril or to any other ingredients in the medicine, children or adolescents aged under 18 years, pregnancy, patients with a condition known as angioneurotic oedema (swelling of the face, tongue or throat which causes difficulty breathing), history of angioedema (swelling) related to previous treatment with an ACE inhibitor, narrowing of the main blood vessels from the heart (known as aortic stenosis).
Also see list of precautions and interactions
Do not store above 25ºC.
What is it used for?
- Quinapril is used to widen blood vessels in the body which can lead to a reduction in the blood pressure in the vessels.
- It is an angiotensin converting enzyme inhibitor, sometimes known as an ACE inhibitor.
- It is used to block the action of angiotensin converting enzyme (ACE) which is produced naturally in the body. ACE produces angiotensin II in the body, a compound which increases the pressure within the blood vessels by constricting and narrowing the vessels. By blocking ACE, quinapril reduces the production of angiotensin II, which allows the blood vessels to relax and widen. This produces a drop in blood pressure. Because quinapril also enables the blood to be pumped more easily around the body it is also used to treat heart failure, a condition in which the heart does not pump blood around the body as efficiently as it should.
- Benefits of being on this drug can include lowering of blood pressure and relief from symptoms of heart failure including shortness of breath and breathing problems, and increased survival.
Listed below are the typical uses of quinapril.
On occasion your doctor may prescribe this medicine to treat a condition not on the above list.
HOW TO USE/TAKE
How often do I take it?
- Take this medication by mouth usually once or twice a day as instructed by your doctor, with or without food. Swallow the tablets whole with a glass of water. Do not crush, chew or divide the tablets.
- Use this medication regularly in order to get the most benefit from it.
- Remember to use it at the same time each day - unless specifically told not to by your doctor.
- It may take up to two weeks before the full benefit of this drug takes effect.
- Certain medical conditions may require different dosage instructions as directed by your doctor.
- Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.
Do I need to avoid anything?
- Quinapril may affect your ability to drive or operate machinery and may make you feel dizzy and tired. If you have these symptoms do not drive or operate machinery. Consult your doctor or pharmacist for more details.
When can I stop?
- It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
QUINAPRIL SIDE EFFECTS
- Feeling sick or being sick
- Chest infection
- Nasal stuffiness and/or a runny nose
- Painful muscles
- Muscle weakness
- Back pain
- Joint pain (gout)
- Feeling weak
- Kidney and urinary problems
- Numbness or a tingling feeling in your arms and legs
- Feeling nervous
- Water (fluid retention) in your body
- Inflammation of the sinuses
- Blurred vision
- Difficulty achieving an erection in males
If any of these persist or you consider them severe then inform your doctor or pharmacist.
Tell your doctor immediately and stop taking quinapril if you develop any of the following symptoms:
- Swelling of the face, tongue and throat which causes difficulty breathing (this may be a sign of angioedema and you should could an ambulance immediately)
- Severe pain in the abdomen causing you to be sick (this may be a sign of intestinal angioedema and you should call an ambulance immediately)
- Heart attack or speeding up of the heart rate (you should call an ambulance immediately)
- Weakness of arms, legs or problems speaking (this may be a sign of a stroke and you should call an ambulance immediately)
- Severe skin rash, itching, blistering, swelling and peeling of the skin and inflammation of mucous membranes such as the mouth and lips (this may be a sign of Stevens Johnson syndrome and you should call an ambulance immediately)
- Severe allergic reaction (you should call an ambulance immediately)
- Feeling faint particularly when standing
- Severe sore throat or severe mouth ulcers particularly if you have kidney problems or collagen vascular disease (deposits of collagen in the blood vessels)
- Chest pain, tightness of the chest, shortness of breath, wheezing or trouble breathing, irregular or strong heartbeat (palpitations)
- Severe pain in the abdomen and back and feeling unwell
- Yellowing of the skin or whites of the eyes.
Further information about other side effects can be found in the patient information leaflet.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.
Before taking quinapril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors; or if you have any other allergies.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: an allergy to quinapril or to any other ingredients in the medicine, you are pregnant or breastfeeding, angioneurotic oedema (swelling of the face, tongue or throat which causes difficulty breathing), history of angioedema (swelling) related to previous treatment with an ACE inhibitor, narrowing of the main blood vessels from the heart (known as aortic stenosis).
Before using this medication tell your doctor or pharmacist your medical history, especially any of the following kidney disease, liver disease, you use a haemodialysis machine (artificial kidney), heart disease, disease of the circulatory system, deposits of collagen in the blood vessels (collagen vascular disease), you are having or are about to have low density lipoprotein apheresis treatment (removal of cholesterol from the blood by a machine), allergies and asthma, you are having or are about to have desensitisation treatment to reduce the effects of an allergy, diabetes, renal artery stenosis (narrowing of the blood vessels to the kidneys), low sodium diet, intolerance to certain sugars.
Before having surgery, tell your doctor or dentist that you are taking this medication.
Does alcohol intake affect this drug?
- You should avoid alcohol while taking quinapril.
The elderly: quinapril should be used with caution in the elderly as it is eliminated from the body more slowly than in younger patients.
Pregnancy and breastfeeding - please ensure you read the detailed information below
Quinapril is not safe to take if you are, or are planning to become, pregnant.
It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.
If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Quinapril is not safe to take if you are breastfeeding.
It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.
If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.
If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.
The following medicines may interact with quinapril:
- Tetracyclines, a type of antibiotics
- Angiotensin-II receptor antagonists
- Other medicines for high blood pressure
- Water tablets (diuretics)
- Potassium supplements
- Non-steroidal anti-inflammatory painkilling drugs (NSAIDs) such as ibuprofen or aspirin
- Steroids, such as hydrocortisone or prednisolone
- Antacids for indigestion and heartburn
- Medicines for diabetes including insulin
- Medicines for cancer
- Medicines for anxiety
- Medicines used to supress the immune system, e.g. ciclosporin
- Allopurinol, used for the treatment of chronic gout
- Sympathomimetic drugs for heart failure and shock
- Medicines that has a sedative effect, such as sleeping pills
This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.
If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.
Taking too much quinapril may cause the following: very low blood pressure (severe hypotension) and dizziness.
People who have taken too much quinapril should tell their doctor or go to the nearest hospital casualty department immediately.
If you think you, or someone you care for, might have accidentally taken more than the recommended dose of quinapril or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.
If you forget to take a dose, miss out the forgotten dose completely and take the next dose at the normal time. Do not double the dose to make up for a missed dose.