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Brand Name(s) : Crestor
Side Effects


Rosuvastatin should be used with caution in: the elderly (those over 70 years of age), those of Asian origin (e.g. Japanese, Chinese, Indian, Filipino, Vietnamese or Korean), patients who have previously had liver disease or who regularly drink alcohol to excess, people with severe respiratory problems, those with an underactive thyroid (hypothyroidism), kidney problems, or patients awaiting surgery, and those who have or have ever had muscle pain or cramps, or if the patient or a close family member has an inherited (genetic or hereditary) muscle disorder, and patients with acute porphyria (a blood disease).

It should not be used in: patients with current liver problems, severe kidney problems, people with muscle disease, women who are pregnant, likely to become pregnant (women of child-bearing potential not using contraception) or who are breastfeeding, people taking a medicine called ciclosporin.

In addition rosuvastatin 40mg should not be used in: people with moderate kidney problems, people with an underactive thyroid (hypothyroidism), people of asian origin, people who regularly drink alcohol to excess, people who have or ever had muscle aches or pains, people who take other medicines like fibrates.

Also see list of precautions and interactions.


Store below 30°C.


What is it used for?

  • Rosuvastatin is used to treat a number of problems.
  • It is a member of a class of lipid-modifying drugs called the hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, sometimes known as statins.
  • It is used to modify levels of lipids (fats) in the blood.
  • In general this drug is used to reduce high (harmful) levels of low-density lipoprotein cholesterol (LDL-C) in the blood, but is also used to reduce high levels of other blood lipids such as triglycerides or to increase levels of a type of cholesterol that protects against heart disease and stroke (high-density lipoprotein cholesterol, or HDL-C).
  • Benefits of being on this drug include reducing the likelihood of cardiovascular disease events (e.g. heart attacks, stroke) and prolonged life.

Listed below are the typical uses of rosuvastatin.

  • Treating abnormal blood cholesterol or triglyceride levels (hypercholesterolaemia or mixed dyslipidaemia) in conjunction with diet
  • For patients who have a type of inherited and severe hypercholesterolaemia, either as an additional treatment to diet and other lipid-lowering treatments, or when patients' lipid levels have not responded to other treatments.
  • Prevention of heart and blood vessels events (e.g. heart attack, stroke) in people who are at high risk of developing these events.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.


How often do I take it?

  • Take this medication by mouth, once daily at any time of day, with or without food. Tablets should be taken whole with a drink of water.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Avoid drinking excessive quantities of alcohol. It is normally safe to drive or operate machinery unless rosuvastatin causes dizziness.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


Only the most common side effects have been listed. If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: muscle aches and pains, tenderness, weakness or cramps, particularly if you also feel generally unwell and/or have a fever.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking rosuvastatin, tell your doctor or pharmacist if you are allergic to it; or to other similar drugs (statins); or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: any liver or kidney problems, an underactive thyroid (hypothyroidism), if you drink substantial quantities of alcohol, or if you have muscle pains, cramps or muscle tenderness or weakness.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: any previous liver problems, any previous unexplained muscle pains, cramps or muscle tenderness or weakness, you or you have a close family member who has had a hereditary (genetic) muscle disorder or muscle problems with statins or other lipid-modifying drugs, severe respiratory problems, or if you have acute porphyria (a blood disease).

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Yes. Avoid drinking large quantities of alcohol whilst taking rosuvastatin.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Rosuvastatin is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Rosuvastatin is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with rosuvastatin:

  • Lipid-modifying medicines called fibrates (e.g. gemfibrozil or fenofibrate) or lipid-modifying doses of nicotinic acid
  • Ciclosporin, an immunosuppressant
  • Fusidic acid
  • Remedies for indigestion (antacids)
  • Antibiotics e.g. erythromycin or daptomycin
  • Antiviral medicines e.g. amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir or tipranavir)
  • Blood-thinning medicines e.g. warfarin, acenocoumarol or phenindione
  • Oral contraceptive/hormone replacement therapy (e.g. oestrogens and progesterones)
  • Colchicine, used in the treatment of gout

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


No specific symptoms of an overdose have been reported for rosuvastatin.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of rosuvastatin or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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